Ing. Michal Šimek

This study investigated whether voice quality is differentially affected in two distinct basal ganglia disorders causing hypokinetic and hyperkinetic dysarthria, including effects of gender and speaking task. The sustained vowel phonations and monologues of 40 de novo Parkinson's disease (PD) patients, 40 Huntington's disease (HD) patients, and 40 healthy control participants were evaluated. Using cepstral peak prominence extracted from sustained phonation, differences from controls were found for male and female HD patients (p < 0.05) but only male PD patients (p < 0.05). Using the glottal-to-noise excitation ratio obtained from monologue, differences from controls were detected for male and female PD groups (p < 0.05) but only male HD group (p < 0.05). In general, female patients show better voice quality. Our findings highlight that selecting suitable acoustic measures and speaking material is essential for adequate evaluation of dysphonia severity across differing etiologies.

Dysphonia is a common speech disruption in people with Parkinson's (PD) and Huntington's (HD). Though the glottal source analysis (GSS) yielded promising results in PD, no study analyzed utility of the GSS in HD. In addition, the potential GSS sex-dependency remains unknown. This study examines sustained vowel phonations provided by 40 PD, 40 HD and 40 age- and sex-matched healthy participants using six GSS features including normalized amplitude quotient, quasi-open quotient, magnitude difference of first two spectral peaks, harmonic richness factor, maximum dispersion quotient (MDQ), and peak slope. Our results showed significant differences in HD men and women compared to the healthy counterpart, suggesting breathiness (p < 0.01), tension (p < 0.001), and decreased timbre (p < 0.01) in HD. Reported sex-related differences highlighted the sensitivity of the GSS towards the speaker's sex. The correlation analysis revealed significant relationship between disease severity and MDQ in HD men.

Background: Patients with synucleinopathies frequently display language abnormalities. However, whether patients with isolated rapid eye movement sleep behavior disorder (iRBD) have prodromal language impairment remains unknown. Objectives: We examined whether the linguistic abnormalities in iRBD can serve as potential biomarkers for conversion to synucleinopathy, including the possible effect of mild cognitive impairment (MCI), speaking task, and automation of analysis procedure. Methods: We enrolled 139 Czech native participants, including 40 iRBD without MCI and 14 iRBD with MCI compared to 40 PD without MCI, 15 PD with MCI, and 30 healthy controls. Spontaneous discourse and story tale narrative were transcribed and linguistically annotated. A quantitative analysis was performed computing 3 linguistic features. Human annotations were compared to fully-automated annotations. Results: Compared to controls, iRBD patients showed poorer content density, reflecting the reduction of content words and modifiers. Both PD and iRBD subgroups with MCI manifested less occurrence of unique words and a higher number of n-grams repetitions, indicating poorer lexical richness. The spontaneous discourse task demonstrated language impairment in iRBD without MCI with an area under the curve of 0.72, while the story tale narrative task better reflected the presence of MCI, discriminating both PD and iRBD subgroups with MCI from controls with an area under the curve of up to 0.81. A strong correlation between manually and automatically computed results was achieved. Conclusions: Linguistic features might provide a reliable automated method for detecting cognitive decline due to prodromal neurodegeneration in subjects with iRBD, providing critical outcomes for future therapeutic trials.

Although cepstral peak prominence (CPP) and its smooth variant (CPPS) are considered robust acoustic measures for the evaluation of dysphonia, whether they are sensitive to capture early voice changes in Parkinson’s disease (PD) has not yet been explored. This study aimed to investigate voice changes via CPP measures in idiopathic rapid eye movement sleep disorder behaviour (iRBD), a special case of prodromal neurodegeneration, and in both newly diagnosed, and advanced-stage PD patients using different speaking tasks across noise-free and noisy environments. The sustained vowel phonation, the reading of passages and the monologues of 60 early-stage untreated PD, 30 advanced-stage PD, 60 iRBD, and 60 healthy control (HC) participants were evaluated. We found significant differences between both PD groups and the controls in sustained phonation via CPP (p < 0.05) and CPPS (p < 0.01) and in monologue via CPP (p < 0.01), although neither CPP nor CPPS measures were sufficiently sensitive to capture possible prodromal dysphonia in iRBD. The quality of both CPP and CPPS measures was influenced substantially by the addition of ambient noise. We anticipated that CPP measures might serve as a promising digital biomarker in assessing dysphonia from the early stages of PD.