prof. Ing. Jan Vrba, CSc.

Applications of Microwaves in Medicine and Biology

Autoři: Vrba, D., prof. Ing. Jan Vrba, CSc., Fišer, O., Cumana Morales, J., Babák, M., Vrba, J.
Publikace: Recent Microwave Technologies. London: IntechOpen Limited, 2022. p. 1-25. ISBN 978-1-80355-927-8.
Rok: 2022

DOI: 10.5772/intechopen.105492
Odkaz: https://doi.org/10.5772/intechopen.105492
Pracoviště: Katedra elektromagnetického pole
Anotace:
This chapter deals with the description of recent research activities oriented on the perspective of microwave technologies in medicine and biology. It brings new ideas about the possibilities of using microwaves in thermotherapy—above all toward hyperthermia in cancer treatment. Development of new types of hyperthermia applicators (based, e.g., on technologies such as metamaterials, evanescent modes in waveguides, and other types of transmission structures) will be discussed here. Furthermore, we would like to underline in this chapter perspectives of microwaves in medical diagnostics. It is possible to expect that, e.g., microwave differential tomography, UWB radar, and microwave radiometers (all three can be used both for medical diagnostic and for noninvasive temperature measurement) will soon play an important role in it. Finally, experimental equipment necessary for research on the biological effects of EM fields is presented.

Model of a 4-waveguide Regional Applicator for Microwave Hyperthermia

Autoři: Babák, M., prof. Ing. Jan Vrba, CSc.,
Publikace: Proceedings of the 2022 Photonics & Electromagnetics Research Symposium (PIERS). Beijing: IEEE, 2022. p. 378-381. ISSN 1559-9450.
Rok: 2022

DOI: 10.1109/PIERS55526.2022.9792942
Odkaz: https://doi.org/10.1109/PIERS55526.2022.9792942
Pracoviště: Katedra elektromagnetického pole
Anotace:
In this contribution we would like to describe a feasibility study of a regional applicator for microwave hyperthermia based on principle of four waveguides. Such the microwave multiport enables to focus the microwave power into the area to be treated. Whole applicator was simulated by finite difference time domain (FDTD) method implemented in SEMCAD X. We implemented the discussed applicator and we verified it experimentally in our laboratory. The values of the S11 parameters were measured by the vector analyzer below the level of (-15) to (-50) dB for all waveguides. Four reflectors have been added to our model in order to help to better focus of the SAR around the central part of the phantom. At the end we studied the temperature distribution.

Sensor for Microwave Medical Diagnostics Based on Array of 8 Waveguides

Autoři: Babák, M., prof. Ing. Jan Vrba, CSc.,
Publikace: Proceedings of the 2022 Photonics & Electromagnetics Research Symposium (PIERS). Beijing: IEEE, 2022. p. 382-386. ISSN 1559-9450.
Rok: 2022

DOI: 10.1109/PIERS55526.2022.9792845
Odkaz: https://doi.org/10.1109/PIERS55526.2022.9792845
Pracoviště: Katedra elektromagnetického pole
Anotace:
In our contribution we will describe the implementation of an applicator for diagnostics in medicine and for non-invasive temperature measurement in hyperthermia based on 8 waveguides filled with distilled water. After the theoretical design of the applicator a numerical model was made in a 3D EM field simulator SEMCAD X, in which the design was verified and subsequently optimized with respect to impedance antenna adaptation. In our simulations, the antennas reached the selected design frequency parameter module |Sii| = −36 dB and |Sij | in the range of −40 dB to −50 dB at design frequency of 1 GHz. We subsequently manufactured the proposed applicator and performed a series of measurements to verify its functionality on an agar phantom mimiking the muscle tissue. The measurements were performed on a VNA with a switching matrix 2 : 24, so the whole S matrix of the scattering parameters was measured at once. Result of these measurements has shown, that at the working frequency reflection parameters |Sii| are in the range from −22 dB to −37 dB and transmission parameters |Sij | are in the range of −51 dB to −73 dB. To verify that the EM wave actually binds to the agar phantom,

UWB Bowtie Antenna for Medical Microwave Imaging Applications

Autoři: Fišer, O., Hrubý, V., prof. Ing. Jan Vrba, CSc., Dřížďal, T., Tesařík, J., Vrba, J., Vrba, D.
Publikace: IEEE Transactions on Antennas and Propagation. 2022, 70(7), 5357-5372. ISSN 0018-926X.
Rok: 2022

DOI: 10.1109/TAP.2022.3161355
Odkaz: https://doi.org/10.1109/TAP.2022.3161355
Pracoviště: Katedra elektromagnetického pole
Anotace:
This work presents a design and experimental validation of a compact ultrawideband (UWB) bowtie antenna and balanced-to-unbalanced (balun) circuit for medical microwave imaging (MWI) applications working in the frequency band of 1-6 GHz. The UWB balun is perpendicularly attached to the planar bowtie arms, whose dimensions were miniaturized by rounding the bowtie edges. The antenna reflection coefficient was lower than -12 dB for tissues with a higher water content. The antenna possesses a high radiation efficiency (over 80%) and very low backward radiation. The predicted and measured specific absorption rate (SAR) distributions together with the electric field vertical bar E vertical bar distribution proved a symmetrical radiation pattern. The potential of the presented antenna element was demonstrated by successful reconstruction of the images from the measured data by MWI methods. For this purpose, an MWI system equipped with eight antennas was implemented. The radar approach was used to determine the region of interest (ROI) where the area for microwave tomography reconstruction was identified. The dielectric properties within the ROI were reconstructed by using the Born approximation method at 1 GHz. This confirmed that the antenna can be used as the basis for more accurate multifrequency MWI systems and can be implemented in UWB MWI hybrid systems.

Waveguide Array Applicator for Microwave Medical Imaging

Autoři: Babák, M., prof. Ing. Jan Vrba, CSc.,
Publikace: Proceedings of the 52nd European Microwave Conference. Louvain-la-Neuve: European Microwave Association (EuMA), 2022. p. 187-190. ISBN 9782874870699.
Rok: 2022

DOI: 10.23919/EuMC54642.2022.9924394
Odkaz: https://doi.org/10.23919/EuMC54642.2022.9924394
Pracoviště: Katedra elektromagnetického pole
Anotace:
In this paper, we propose a novel idea of a diagnostic applicator composed of an array of 8 waveguides filled with distilled water, which can be used for non-invasive temperature measurement based on microwave tomography during cancer treatment using microwave hyperthermia. The waveguide design procedure and simulation results from SEMCAD X are presented. To verify the impedance matching of the applicator, scattering matrix measurements were performed with a muscle tissue agar phantom. Measurements with dielectric inhomogeneity in the agar phantom region are presented to demonstrate the feasibility of using our design for further developments in this area.

Computer-aided design methodology for inductive compensated microwave class-E power amplifier

Autoři: Cumana Morales, J., Vrba, J., prof. Ing. Jan Vrba, CSc.,
Publikace: International Journal of RF and Microwave Computer-Aided Engineering. 2021, 31(12), ISSN 1096-4290.
Rok: 2021

DOI: 10.1002/mmce.22910
Odkaz: https://doi.org/10.1002/mmce.22910
Pracoviště: Katedra elektromagnetického pole
Anotace:
This paper presents a simulation-based analysis to firstly evaluate the impact of excessive transistor output capacitance on class-E power amplifiers and to secondly show how inductive compensation can be used to recover optimum class-E operating conditions

Experimental Study of Optimal Antenna Array Configuration for Non-invasive UWB Microwave Temperature Monitoring during Hyperthermia

Autoři: Prokhorova, A., Fišer, O., prof. Ing. Jan Vrba, CSc., Helbig, M.
Publikace: 2021 IEEE Conference on Antenna Measurements & Applications (CAMA). Piscataway: IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC., 2021. p. 529-534. ISBN 978-1-7281-9697-8.
Rok: 2021

DOI: 10.1109/CAMA49227.2021.9703455
Odkaz: https://doi.org/10.1109/CAMA49227.2021.9703455
Pracoviště: Katedra elektromagnetického pole
Anotace:
Temperature monitoring during thermal therapies is used to regulate the amount of heat distributed to the cancerous tissue and therefore improve the clinical outcome of the oncological treatment. For the development of a hybrid hyperthermia system with non-invasive temperature monitoring by means of ultra-wideband (UWB) imaging, the optimal configuration of sensing antennas and heating applicators has to be investigated. In this paper we present the results of numerical simulations of several possible antenna arrangements, which are then validated by experiments with the radar system. The performance of each channel configuration was analyzed and benefits for the different clinical scenarios were specified.

Advanced Temperature Dielectric Spectroscopy Of Muscle Phantom At Microwave Frequencies

Autoři: Fišer, O., Kantová, M., Ley, L., Prokhorova, A., Helbig, M., prof. Ing. Jan Vrba, CSc.,
Publikace: 2020 14TH EUROPEAN CONFERENCE ON ANTENNAS AND PROPAGATION (EUCAP). IEEE (Institute of Electrical and Electronics Engineers), 2020. p. 49-53. ISBN 978-88-31299-00-8.
Rok: 2020

DOI: 10.23919/EuCAP48036.2020.9135633
Odkaz: https://doi.org/10.23919/EuCAP48036.2020.9135633
Pracoviště: Katedra elektromagnetického pole
Anotace:
The temperature dependency of the dielectric properties of tissues is very important for the development of novel microwave systems intended for non-invasive temperature monitoring. This paper deals with the measurement and optimization of the temperature dependence of the dielectric parameters of a muscle tissue mimicking phantom. The measurements were performed in the frequency band 0.1-3 GHz and in the temperature range 25-45°C. The differences in the dielectric parameters caused by temperature change were analyzed and compared with the reference.

Electromagnetic communication between cells through tunneling nanotubes

Autoři: Pokorny, J., Pokorny, J., prof. Ing. Jan Vrba, CSc.,
Publikace: International Journal of Microwave and Wireless Technologies. 2020, 12(9), 831-838. ISSN 1759-0787.
Rok: 2020

DOI: 10.1017/S175907872000046X
Odkaz: https://doi.org/10.1017/S175907872000046X
Pracoviště: Katedra elektromagnetického pole
Anotace:
Structures of tunneling nanotubes (TNTs) of the circular cross-section of 50 and 200 nm and length up to 1 mm form a communication system between cells. While transport of material such as endocytic vesicles, mitochondria, proteins, cytoplasmic molecules, etc., is experimentally proven, a possible transfer of electric and electromagnetic energy across TNTs corresponding to electrotechnical processes of excitation, propagation, and amplification in cavity systems is yet in a beginning stage of research. The ideas presented in this paper are based on technical mechanisms applied to submicroscopic systems. Main features of corrugated periodic structures, electromagnetic circular waveguides, the Manley-Rowe amplification, the Frohlich non-linear interaction of coherent electric polar vibrations, and description of cut-off frequency propagating limits in the waveguide and cavities and along periodic structures are discussed. We suggest that cell-to-cell connection with TNTs may form a unified coherent cavity system which enables simultaneity and mutual cooperation in multicellular organisms.

Temperature Dependent Dielectric Properties of Tissue Mimicking Phantom Material in the Microwave Frequency Range

Autoři: Prokhorova, A., Ley, S., Fišer, O., prof. Ing. Jan Vrba, CSc., Sachs, J., Helbig, M.
Publikace: 2020 14TH EUROPEAN CONFERENCE ON ANTENNAS AND PROPAGATION (EUCAP). IEEE (Institute of Electrical and Electronics Engineers), 2020. p. 49-53. ISBN 978-88-31299-00-8.
Rok: 2020

DOI: 10.23919/EuCAP48036.2020.9135466
Odkaz: https://doi.org/10.23919/EuCAP48036.2020.9135466
Pracoviště: Katedra elektromagnetického pole
Anotace:
Microwave sensing represents a promising approach for non-invasive tissue temperature monitoring during hyperthermia treatment. Tissue mimicking phantom materials with corresponding dielectric properties and suitable for heating experiments are essential for preliminary methodical investigations as well as for the development of the measurement hardware.In the present paper, a fat tissue mimicking phantom material is investigated depending on the temperature in the range between 30°c and 50°c and the frequency range between 0.5 GHz and 7 GHz. The measured data are modeled by means of a two-pole Cole-Cole model and the temperature dependence of the Cole-Cole parameters is fitted by means of a second-order polynomial. The results show that this material imitate the dielectric properties of real fat tissue as well as its very low temperature dependence appropriately and can be used for practical experiments.

Temperature dependent dielectric spectroscopy of muscle tissue phantom

Autoři: Fišer, O., Ley, S., Helbig, M., Sachs, J., Kantová, M., prof. Ing. Jan Vrba, CSc.,
Publikace: International Journal of Microwave and Wireless Technologies. 2020, 2020 885-891. ISSN 1759-0787.
Rok: 2020

DOI: 10.1017/S1759078720000203
Odkaz: https://doi.org/10.1017/S1759078720000203
Pracoviště: Katedra elektromagnetického pole
Anotace:
The temperature dependence of the dielectric parameters of tissues and tissue-mimicking phantoms is very important for non-invasive temperature measurement in medical applications using microwaves. We performed measurements of this dependence in the temperature range 25-50 °C using distilled water as a reference liquid commonly used in dielectric properties studies. The results were compared with the literature model in the frequency range 150 – 3000 MHz. Using this method, the temperature dependence of dielectric parameters of a new muscle tissue-mimicking phantom based on agar, polyethylene powder and polysaccharide material TX-151 was measured in the temperature range 25 - 50 °C. The temperature dependence of dielectric properties of this new muscle phantom was fitted to that of the two-pole Cole-Cole model and the deviation of the results between measured and modelled data was quantified.

Applications of Microwaves in Medicine and Biology

Autoři: prof. Ing. Jan Vrba, CSc., Vrba, J., Vrba, D., Fišer, O., Ing. Ladislav Oppl, Ph.D., Merunka, I.
Publikace: Proceedings of European Microwave Conference in Central Europe, EuMCE 2019. Louvain-la-Neuve: European Microwave Association (EuMA), 2019. p. 496-499. ISBN 9782874870675.
Rok: 2019

Pracoviště: Katedra elektromagnetického pole
Anotace:
Paper deals with description of research results in the area of applications of microwaves in medicine and biology done in the Czech Republic (mainly at the Czech Technical University in Prague), since the year 1981. It gives information about microwave technology in thermotherapy, oriented above all on cancer treatment. Principles for implementation of hyperthermia applicators will be mentioned. New ideas for 3D non-invasive temperature monitoring for hyperthermia cancer treatment, based on UWB radar system, will be discussed. Overview of prospective microwave methods in medical diagnostics, e.g. microwave radiometry, microwave differential tomography, etc. will be given. Last but not least, research of biological effects of EM fields (both thermal and non-thermal) will be presented. We will underline international cooperation of Czech researchers with experts from other countries.

Feasibility of Pancreatic Cancer Treatment by Aid of Microwave Interstitial Hyperthermia Applicators

Autoři: prof. Ing. Jan Vrba, CSc., Vojáčková, L., Fišer, O., Vrba, D., Vrba, J.
Publikace: Proceedings of European Microwave Conference in Central Europe, EuMCE 2019. Louvain-la-Neuve: European Microwave Association (EuMA), 2019. p. 444-447. ISBN 9782874870675.
Rok: 2019

Pracoviště: Katedra elektromagnetického pole
Anotace:
Main aim of this paper is to study (based on numerical simulations) technical feasibility of pancreatic cancer treatment by aid of microwave hyperthermia – using array of 4 microwave helix interstitial hyperthermia applicators. These simulations were performed in EM field simulator SEMCAD X for 3 different ISM frequencies: 434, 915 and 2450 MHz. Comparison of SAR distribution value (Specific Absorption Rate) simulated on these 3 frequencies is discussed. "High-Resolution Human Models for Simulations: Virtual Population" were used for this study. Final aim of this feasibility study was to identify most suitable frequency (from those mentioned above) for the pancreatic cancer treatment. Keywords-Microwave hyperthermia, pancreatic cancer treatment, interstitial helix applicator, BPH, hyperthermia applicators.

High-water Content Phantom for Microwave Imaging and Microwave Hyperthermia

Autoři: Kantová, M., Fišer, O., Merunka, I., prof. Ing. Jan Vrba, CSc., Tesařík, J.
Publikace: World Congress on Medical Physics and Biomedical Engineering 2018. Springer Nature Singapore Pte Ltd., 2019. p. 779-783. IFMBE Proceedings. vol. 68/2. ISSN 1680-0737. ISBN 978-981-10-9038-7.
Rok: 2019

DOI: 10.1007/978-981-10-9023-3_141
Odkaz: https://doi.org/10.1007/978-981-10-9023-3_141
Pracoviště: Katedra elektromagnetického pole
Anotace:
The main goal of this contribution is the investigation, design, and evaluation of an agar-based high-water content phantom for microwave imag-ing and hyperthermia. The contribution attempts to specify preparing procedure to get the most uniform results and describes the problems during the fabrica-tion of the phantom, solves the problem with air bubbles. The effect of the size of PE powder particles to dielectric properties (40-48 and 150 microns) was evaluated. Dielectric properties of agar phantoms with different compositions of grape sugar and polyethylene powder were compared for lowering the relative part of the complex permittivity over the frequency range of 10 MHz to 2995 MHz. Proposed phantom also consists of agar powder, distilled water, sodium chloride and TX-151. The relative permittivity was decreased to the value under 60 at frequency 434 MHz for muscle phantom with available equipment and fabrication (with 13.23 % PE powder, 40-48 microns).

Lens Applicator for Deep-local Treatment of Cancer by Microwave Hyperthermia

Autoři: prof. Ing. Jan Vrba, CSc., Kubeš, J., Třebícký, F., Vrba, J., Vrba, D., Merunka, I., Cumana Morales, J., Fišer, O.
Publikace: Progress in Electromagnetics Research Symposium. Institute of Electrical and Electronics Engineers, Inc., 2019. p. 2547-2550. ISSN 1559-9450. ISBN 9781728134031.
Rok: 2019

DOI: 10.1109/PIERS-Spring46901.2019.9017304
Odkaz: https://doi.org/10.1109/PIERS-Spring46901.2019.9017304
Pracoviště: Katedra elektromagnetického pole
Anotace:
The paper deals with the introduction of microwave applicator with lens aperture operating at a frequency of 434 MHz. The applicator has a convergent effect of transmitted electromagnetic waves in lossy dielectrics the value of the relative permittivity close to the values of biological tissues. This study is the preparative phase for future development of a lens applicator based on metamaterial technology.

Non-contact Monitoring of Respiration and Heart Activity of Infants Using UWB Signals

Autoři: Fišer, O., Tesařík, J., Pokorný, T., prof. Ing. Jan Vrba, CSc.,
Publikace: Progress in Electromagnetics Research Symposium. Institute of Electrical and Electronics Engineers, Inc., 2019. p. 2534-2537. ISSN 1559-9450. ISBN 9781728134031.
Rok: 2019

DOI: 10.1109/PIERS-Spring46901.2019.9017595
Odkaz: https://doi.org/10.1109/PIERS-Spring46901.2019.9017595
Pracoviště: Katedra elektromagnetického pole
Anotace:
The main purpose of this contribution is to introduce a new system which is able to simultaneously to monitor the breathing and heart activity of an infant. The working frequency band of the system is 1 - 8 GHz. Three bow-tie antennas (1 transmitter Tx and 2 receivers Rx) are placed over the neonatal. The antennas are placed 60 cm above the infant. In case of measurement the Tx antenna is emitting the UWB signal, which is reflected from the body and detected by the Rx antennas. The static background is subtracted by the signal mean value. The detection principle is based on the knowledge that the respiratory frequency of an infant (1 - 3 years old) is around 1 Hz and the movement of the chest is about 0.2 mm. This can be detected via UWB radar as peak detection and its movement caused by breathing. In case of infants' apnea, we propose a dynamic threshold. From the signal it is also possible to detect the heart activity.

Numerical Study of Differential Temperature Measurement in Human Muscle Tissue using UWB Radar

Autoři: Fišer, O., Hrubý, V., Ley, L., Helbig, M., Sachs, J., prof. Ing. Jan Vrba, CSc.,
Publikace: 2019 13TH EUROPEAN CONFERENCE ON ANTENNAS AND PROPAGATION (EUCAP). IEEE (Institute of Electrical and Electronics Engineers), 2019. ISSN 2164-3342. ISBN 9788890701887.
Rok: 2019

Pracoviště: Katedra elektromagnetického pole
Anotace:
This paper deals with the numerical study of the differential temperature measurement by means of ultra-wide band (UWB) radar in the muscle tissue. The temperature range of interest corresponds to the hyperthermia tumor treatment (up to 45 degrees C). A 1D model based on Mason graphs and a simplified sandwich structure is introduced to observe the expected usable frequency band and differential signal dependence on the temperature change. Results show a linear dependence of the received radar signals on temperature change in the human muscle phantom. We numerically proved that it is possible to detect temperature changes inside the UWB signals backscattered from the heated region.

Research of Biological Effects of em Field in Microwave Frequency Band

Autoři: prof. Ing. Jan Vrba, CSc., Merunka, I., Cumana Morales, J., Kubeš, J., Třebický, F., Vožech, F., Barcal, J., Vannucci, L., Vrba, J., Vrba, D., Fišer, O.
Publikace: Progress in Electromagnetics Research Symposium. Institute of Electrical and Electronics Engineers, Inc., 2019. p. 1449-1451. ISSN 1559-9450. ISBN 9781728134031.
Rok: 2019

DOI: 10.1109/PIERS-Spring46901.2019.9017804
Odkaz: https://doi.org/10.1109/PIERS-Spring46901.2019.9017804
Pracoviště: Katedra elektromagnetického pole
Anotace:
Research of interactions between EM Field and biological systems is of growing interests elsewhere. Also here in Czech Republic there are several groups working in this field, often in international co-operations. We will describe here mainly basic technical equipment developed for 5 different research projects in the discussed area of interactions of EM field and biological systems

Temperature dependent dielectric spectroscopy of muscle tissue phantom

Autoři: Fišer, O., Ley, S., Helbig, M., Sachs, J., Kantová, M., prof. Ing. Jan Vrba, CSc.,
Publikace: Proceedings of European Microwave Conference in Central Europe, EuMCE 2019. Louvain-la-Neuve: European Microwave Association (EuMA), 2019. p. 550-553. ISBN 9782874870675.
Rok: 2019

Pracoviště: Katedra elektromagnetického pole
Anotace:
The temperature dependence of the dielectric parameters of tissues and tissue mimicking phantoms is very important for the non-invasive temperature measurement in medical applications using microwaves. We investigated and proposed a procedure of the measurement of this dependence in the temperature range 25 - 50 °C. Our proposed procedure was verified using distilled water. The results were compared to the literature model in the frequency range 150 - 3000 MHz. Using this method, the temperature dependence of dielectric parameters of new tissue mimicking phantom based on agar, PE powder and TX-151 was measured in the temperature range 25 -50 °C.

Ultra-Wideband Temperature Dependent Dielectric Spectroscopy of Blood in the Microwave Frequency Range

Autoři: Ley, S., Schilling, S., Fišer, O., prof. Ing. Jan Vrba, CSc., Sachs, J., Helbig, M.
Publikace: 2019 13TH EUROPEAN CONFERENCE ON ANTENNAS AND PROPAGATION (EUCAP). IEEE (Institute of Electrical and Electronics Engineers), 2019. ISSN 2164-3342. ISBN 9788890701887.
Rok: 2019

Pracoviště: Katedra elektromagnetického pole
Anotace:
The knowledge of temperature dependent dielectric properties of biological tissue in the microwave frequency range is crucial for medical applications such as microwave temperature monitoring during oncological treatments. This paper deals with temperature dependent dielectric spectroscopy of blood by means of ultra-wideband sensing. We present the results of relative permittivity and conductivity of blood without agents and blood with heparin in the frequency range of 0.5 GHz up to 7 GHz and in the temperature range between 30 degrees C and 50 degrees C. The measurements show that the addition of heparin does not affect the dielectric properties in the considered frequency and temperature range. Furthermore, the measurements are compatible with the few data reported in the literature.

Ultra-wideband temperature dependent dielectric spectroscopy of porcine muscle in the microwave frequency range

Autoři: Ley, S., Schilling, S., Fišer, O., prof. Ing. Jan Vrba, CSc., Sachs, J., Prokhorova, A., Helbig, M.
Publikace: Proceedings of European Microwave Conference in Central Europe, EuMCE 2019. Louvain-la-Neuve: European Microwave Association (EuMA), 2019. p. 554-557. ISBN 9782874870675.
Rok: 2019

Pracoviště: Katedra elektromagnetického pole
Anotace:
The knowledge of dielectric properties of tissue is a crucial factor to develop new systems for medical applications. In the field of thermotherapy (e.g. hyperthermia) the frequency and temperature dependency of these properties are of high importance. To this end, we investigate the dielectric properties of porcine muscle in the temperature range between 30 °C and 50 °C from 0.5 GHz to 7 GHz. Based on these data we determine temperature coefficients of the relative permittivity and effective conductivity. In both cases, the results show a weak temperature dependency and a change of sign of the temperature coefficients in the specified frequency range.

Ultra-Wideband Temperature Dependent Dielectric Spectroscopy of Porcine Tissue and Blood in the Microwave Frequency Range

Autoři: Ley, S., Schilling, S., Fišer, O., prof. Ing. Jan Vrba, CSc., Sachs, J., Helbig, M.
Publikace: Sensors. 2019, 19(7), ISSN 1424-8220.
Rok: 2019

DOI: 10.3390/s19071707
Odkaz: https://doi.org/10.3390/s19071707
Pracoviště: Katedra elektromagnetického pole
Anotace:
The knowledge of frequency and temperature dependent dielectric properties of tissue is essential to develop ultra-wideband diagnostic technologies, such as a non-invasive temperature monitoring system during hyperthermia treatment. To this end, we characterized the dielectric properties of animal liver, muscle, fat and blood in the microwave frequency range from 0.5 GHz to 7 GHz and in the temperature range between 30 degrees C and 50 degrees C. The measured data were modeled to a two-pole Cole-Cole model and a second-order polynomial was introduced to fit the Cole-Cole parameters as a function of temperature. The parametric model provides access to the dielectric properties of tissue at any frequency and temperature in the specified range.

Microwave Interstitial Applicator Array for Treatment of Pancreatic Cancer

Autoři: prof. Ing. Jan Vrba, CSc., Vojáčková, L., Fišer, O., Merunka, I.
Publikace: 2018 Progress In Electromagnetics Research Symposium (PIERS | Toyama). Cambridge: Electromagnetics Academy, 2018. p. 150-154. ISSN 1931-7360. ISBN 9784885523151.
Rok: 2018

DOI: 10.23919/PIERS.2018.8597667
Odkaz: https://doi.org/10.23919/PIERS.2018.8597667
Pracoviště: Katedra elektromagnetického pole
Anotace:
The aim of this paper is to check a possibility of usage of interstitial helix applicators for a treatment pancreatic cancer by microwave hyperthermia. This feasibility study is based on the simulations. The simulations were performed in the simulation program of electromagnetic field SEMCAD X for three different frequencies: 434, 915 and 2450 MHz. This paper contains the comparison SAR distribution value (Specific Absorption Rate) simulated on these three frequencies. For simulation procedure was used “High-Resolution Human Models for Simulations: Virtual Population”. The final step this feasibility study was to determine the most suitable frequency for the treatment pancreatic cancer on the base of SAR value.

Microwave non-invasive temperature monitoring using UWB radar for cancer treatment by hyperthermia

Autoři: Fišer, O., Helbig, M., Sachs, J., Ley, S., Merunka, I., prof. Ing. Jan Vrba, CSc.,
Publikace: Progress In Electromagnetics Research. 2018, 2018(162), 1-14. ISSN 1559-8985.
Rok: 2018

DOI: 10.2528/PIER17111609
Odkaz: https://doi.org/10.2528/PIER17111609
Pracoviště: Katedra elektromagnetického pole
Anotace:
Objective: In this paper we present a study of a novel method to noninvasively monitor temperature during thermotherapy for instance in cancer treatment using M-sequence radar technology. The main objective is to investigate the temperature dependence of reflectivity in UWB radar signal in gelatine phantoms using electrically small antennas. Methods: The phantom was locally heated up, and consequently changes of signal reflectivity were observed. Results: An approximate linear relationship between temperature change and reflectivity variations was formulated. To show the potential of this approach we used an M-sequence MIMO radar system. The system was tested on breast-shape phantom with local heating by circulating water of controlled temperature. Delay and Sum algorithm was implemented for two-dimensional imaging. Significance: The article is a study of temperature measurement using UWB radar system for possible usage in thermotherapy. © 2018, Electromagnetics Academy. All rights reserved.

Microwaves in Medical Diagnostics and Treatment

Autoři: prof. Ing. Jan Vrba, CSc., Vrba, J., Vrba, D., Fišer, O., Merunka, I.
Publikace: 2018 Progress In Electromagnetics Research Symposium (PIERS | Toyama). Cambridge: Electromagnetics Academy, 2018. p. 155-159. ISSN 1931-7360. ISBN 9784885523151.
Rok: 2018

DOI: 10.23919/PIERS.2018.8597911
Odkaz: https://doi.org/10.23919/PIERS.2018.8597911
Pracoviště: Katedra elektromagnetického pole
Anotace:
Paper deals with research activities oriented on applications of microwave theory, technique and technologies in medical diagnostics and treatment. A significant importance for the future can be identified for the following methods: Microwave Differential Tomography, Microwave Radiometry, Measurement of Complex Permittivity, Imaging in the Terahertz Waves Band and Microwave Diagnostic Radars.

Numerical Study of Hyperthermia Applicator System for Tumor Treatment in Head and Neck Region

Autoři: Fišer, O., Merunka, I., prof. Ing. Jan Vrba, CSc.,
Publikace: 2018 Progress In Electromagnetics Research Symposium (PIERS | Toyama). Cambridge: Electromagnetics Academy, 2018. p. 770-774. ISSN 1931-7360. ISBN 9784885523151.
Rok: 2018

DOI: 10.23919/PIERS.2018.8597679
Odkaz: https://doi.org/10.23919/PIERS.2018.8597679
Pracoviště: Katedra elektromagnetického pole
Anotace:
The purpose of this contribution is to study the influence of the number of waveguide applicators for the hyperthermia treatment in the head and neck region. The number of applicators observing the SAR distribution in the target of the simple phantom was changing from one to five. The influence of the optimization of the amplitudes and phases for the microwave energy steering was observed. The best result was achieved for four applicators when the difference between optimized and non-optimized SAR 25 was 48%.

Numerical Study of Stroke Detection Using UWB Radar

Autoři: Fišer, O., Hrubý, V., Merunka, I., Vrba, J., prof. Ing. Jan Vrba, CSc.,
Publikace: 2018 Progress In Electromagnetics Research Symposium (PIERS | Toyama). Cambridge: Electromagnetics Academy, 2018. p. 160-163. ISSN 1931-7360. ISBN 9784885523151.
Rok: 2018

DOI: 10.23919/PIERS.2018.8597601
Odkaz: https://doi.org/10.23919/PIERS.2018.8597601
Pracoviště: Katedra elektromagnetického pole
Anotace:
The main purpose of this contribution is the design and feasibility study of a microwave imaging system based on the UWB radar working in the frequency band 1–8 GHz. For the simulation the 3D anatomical head phantom was used. Strokes of different sizes and in different positions were tested. The position of the stroke was estimated by processing reflected signals using delay and sum beamforming algorithm. According to the results the estimated position of the stroke was perfectly matched with the original stroke position. The system also responds to size of the stroke.

Perspective applications of microwaves in medicine

Autoři: Vrba, D., Vrba, J., Fišer, O., Merunka, I., Cumana Morales, J., prof. Ing. Jan Vrba, CSc.,
Publikace: 2018 28th International Conference Radioelektronika. IEEE (Institute of Electrical and Electronics Engineers), 2018. p. 1-4. ISBN 978-1-5386-2485-2.
Rok: 2018

DOI: 10.1109/RADIOELEK.2018.8376399
Odkaz: https://doi.org/10.1109/RADIOELEK.2018.8376399
Pracoviště: Katedra elektromagnetického pole
Anotace:
Our paper is focused on recent research activities in the area of applications of microwaves in medicine and biology. It deals with description of microwave technology in thermotherapy - especially oriented on cancer treatment. Projects on new type hyperthermia applicators (e.g. based on MTM technology, etc.) will be mentioned. Further information about microwaves in medical diagnostics, e.g. projects on microwave differential tomography will be described.

Preliminary Investigations for Non-invasive Temperature Change Detection in Thermotherapy by Means of UWB Microwave Radar

Autoři: Ley, S., Fišer, O., Merunka, I., prof. Ing. Jan Vrba, CSc., Sachs, J., Helbig, M.
Publikace: 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). Piscataway: IEEE, 2018. p. 5386-5389. ISSN 1557-170X.
Rok: 2018

DOI: 10.1109/EMBC.2018.8513555
Odkaz: https://doi.org/10.1109/EMBC.2018.8513555
Pracoviště: Katedra elektromagnetického pole
Anotace:
Non-invasive differential temperature monitoring by means of ultra-wideband sensing is a promising approach concerning temperature controlling during thermotherapy. In this paper the principal of temperature difference detection by UWB radar is explained and appropriate phantom measurements are discussed. In a first step, temperature dependent dielectric properties of the phantom materials (sunflower oil and distilled water) are analyzed. Subsequently, temperature dependent phantom measurements are conducted where the temperature dependent signal changes of the received UWB signals are investigated. Results show a linear behavior between the received differential radar signals and the temperature differences of the target in the considered temperature range. Furthermore, investigations show that temperature changes of the target, which are common in thermal therapy (e.g., hyperthermia), are detectable by means of UWB radar.

Preliminary Investigations for Reliable Temperature Dependent UWB Dielectric Spectroscopy of Tissues and Tissue Mimicking Phantom Materials

Autoři: Ley, L., Fišer, O., Merunka, I., prof. Ing. Jan Vrba, CSc., Sachs, J., Helbig, M.
Publikace: 2018 12th European Conference on Antennas and Propagation. Bruxelles: The European Association on Antennas and Propagation, 2018. p. 1-5. ISSN 0537-9989. ISBN 978-1-78561-815-4.
Rok: 2018

DOI: 10.1049/cp.2018.0789
Odkaz: https://doi.org/10.1049/cp.2018.0789
Pracoviště: Katedra elektromagnetického pole
Anotace:
The temperature dependency of dielectric properties of tissue mimicking materials and tissues is a crucial factor for non-invasive temperature monitoring in microwave thermotherapy. This contribution deals with temperature dependent dielectric spectroscopy measurements by means of ultrawideband sensing. Beside the standard three term calibration, a temperature dependent calibration approach is supposed. Both methods are validated by measuring the dielectric properties of distilled water in the frequency range of 0.5 GHz up to 7 GHz and in the temperature range of 26◦C up to 50◦C. Compared with the Ellison model as reference, the temperature dependent calibration approach shows better results than the standard calibration at room temperature. Furthermore, the temperature dependent dielectric properties of a tumor mimicking agar phantom in the same frequency and temperature range are presented. © Institution of Engineering and Technology.All Rights Reserved.

Research of Biological Effects of EM Field in Microwave Frequency Band

Autoři: prof. Ing. Jan Vrba, CSc., Vrba, J., Vrba, D., Merunka, I., Fišer, O.
Publikace: 2018 Progress In Electromagnetics Research Symposium (PIERS | Toyama). Cambridge: Electromagnetics Academy, 2018. p. 1028-1033. ISSN 1931-7360. ISBN 9784885523151.
Rok: 2018

DOI: 10.23919/PIERS.2018.8597976
Odkaz: https://doi.org/10.23919/PIERS.2018.8597976
Pracoviště: Katedra elektromagnetického pole
Anotace:
Research of interactions between EM Field and biological systems is of growing interests elsewhere. In Czech Republic there are several groups working in this field, often in international co-operations. We will describe here mainly basic technical equipment developed for 3 different research projects in the discussed area of interactions of EM field and biological systems.

Comparative Study of Antennas for Microwave Tomography

Autoři: Merunka, I., Fišer, O., Vrba, J., Vrba, D., prof. Ing. Jan Vrba, CSc.,
Publikace: Proceedings of Progress In Electromagnetics Research Symposium 2017. Cambridge, MA: The Electromagnetics Academy, 2017. p. 727-731. ISSN 1559-9450. ISBN 978-1-5090-6269-0.
Rok: 2017

Pracoviště: Katedra elektromagnetického pole
Anotace:
In this work four different antennas are compared with respect to its suitability for use in microwave tomography system. Aim of this work is to recommend an antenna element for the next generation of our microwave tomography system. Several criteria are defined in this paper and they are evaluated for every tested antenna. These include two microstrip patch antennas, wire monopole antenna and waveguide antenna. While microwave patch antennas fulfil the best most of our criteria, waveguide antenna has the most suitable radiation pattern.

Měření komplexní permitivity biologických tkání

Autoři: Ing. Ladislav Oppl, Ph.D., prof. Ing. Jan Vrba, CSc.,
Publikace: Šíření elektromagnetických vln v biologických tkáních. Pardubice: Univerzita Pardubice, 2017. ISBN 978-80-7560-052-3.
Rok: 2017

Pracoviště: Katedra elektromagnetického pole
Anotace:
Článek se zabývá metodou měření komplexní permitivity biologické tkáně, která je důležitá pro návrh různých technických zařízení využívajících elektromagnetické pole, např. pro mikrovlnnou termoterapii.

Microwave based medical imaging

Autoři: Vrba, J., Vrba, D., Fišer, O., Merunka, I., prof. Ing. Jan Vrba, CSc., Cumana Morales, J.
Publikace: 2017 32nd General Assembly and Scientific Symposium of the International Union of Radio Science, URSI GASS 2017 Volume 2017-January, 10 November 2017, Pages 1-4 32nd General Assembly and Scientific Symposium of the International Union of Radio Science, URSI GASS 2017; Montreal; Canada; 19 August 2017 through 26 August 2017; Category numberCFP1705I-ART; Code 132402. Institute of Electrical and Electronics Engineers, Inc., 2017. p. 1-4. Volume 2017-January. ISBN 9789082598704.
Rok: 2017

DOI: 10.23919/URSIGASS.2017.8105081
Odkaz: https://doi.org/10.23919/URSIGASS.2017.8105081
Pracoviště: Katedra elektromagnetického pole
Anotace:
Our URSI GASS 2017 contribution is focused on resent research activities in the area of microwaves in medical diagnostics. Projects on microwave differential tomography and UWB radar system (both used both for medical diagnostic and for non-invasive temperature measurement as well) will be described.

Microwave Hyperthermia System for Head and Neck Area with Noninvasive UWB Temperature Change Detection

Autoři: Fišer, O., Merunka, I., prof. Ing. Jan Vrba, CSc.,
Publikace: Proceedings of Progress In Electromagnetics Research Symposium 2017. Cambridge, MA: The Electromagnetics Academy, 2017. p. 1657-1662. ISSN 1559-9450. ISBN 978-1-5090-6269-0.
Rok: 2017

DOI: 10.1109/PIERS.2017.8262015
Odkaz: https://doi.org/10.1109/PIERS.2017.8262015
Pracoviště: Katedra elektromagnetického pole
Anotace:
The main topic of this contribution is the design and demonstration of combination the hyperthermia applicator system for head and neck area working on frequency 434 MHz with UWB radar antenna array for differential temperature detection. For our numerical simulations, the simplified homogenous phantom and 3D numerical model of patient were used. For two-dimensional reconstruction of reflected signals the Delay and Sum beamforming algorithm were used. The phantom was locally heated up using the microwave hyperthermia applicator and the temperature distribution was used as an inhomogeneity (through change in relative permittivity and specific conductivity). The results confirm the feasibility and usability of temperature change detection via UWB signal in the head and neck area.

Numerical Feasibility Study of New Combined Hyperthermia System for Head and Neck Region

Autoři: Fišer, O., Merunka, I., prof. Ing. Jan Vrba, CSc.,
Publikace: European Microwave Week 2017 - Conference Proceedings - EuRAD 2017. Louvain-la-Neuve: European Microwave Association (EuMA), 2017. p. 719-722. ISBN 978-2-87487-049-1.
Rok: 2017

DOI: 10.23919/EuMC.2017.8230948
Odkaz: https://doi.org/10.23919/EuMC.2017.8230948
Pracoviště: Katedra elektromagnetického pole
Anotace:
The main goal of this contribution is to make a numerical feasibility study of temperature change detection system combined with the microwave hyperthermia treatment system intended for head and neck region with field optimization possibility. The study is focused mainly if it is feasible to gain some information from the region of interest. For this purpose, the 3D model of a patient having a large tumor of the volume of 246 cm3 is proposed. Obtained imaging results are presented regarding to the usability in clinical practice.

Optimization of Microwave Hyperthermia Applicator System for Deep Placed Tumors Treatment in Head and Neck Area

Autoři: Fišer, O., Merunka, I., prof. Ing. Jan Vrba, CSc.,
Publikace: Proceedings of Progress In Electromagnetics Research Symposium 2017. Cambridge, MA: The Electromagnetics Academy, 2017. p. 1733-1738. ISSN 1559-9450. ISBN 978-1-5090-6269-0.
Rok: 2017

DOI: 10.1109/PIERS.2017.8262029
Odkaz: https://doi.org/10.1109/PIERS.2017.8262029
Pracoviště: Katedra elektromagnetického pole
Anotace:
The purpose of this contribution is to optimize our hyperthermia applicator system intended for the tumor treatment in head and neck area. The system was redesigned to gain the focusing improved SAR and temperature distribution in large and deep seated tumors. For this purpose, two numerical phantoms: homogenous and 3D anatomical model were proposed. Three parameters were changing (applicators polarization, applicators distance between applicators and numerical model, water bolus temperature) observing their influence on reflection coefficient, SAR and temperature distribution in the treated area. For the best arrangement the SAR25 (71.3 %) and T41 (94 %) tumor coverage with reflection coefficient –24 dB were achieved. This is fully sufficient for the clinical utilization. The system improvement is representing a 22 % increase in SAR25 parameter compared to the original proposal for superficial tumors.

Comparison of three UWB microwave antennas intended for brain stroke detection system

Autoři: Fišer, O., Merunka, I., Vrba, D., Vrba, J., prof. Ing. Jan Vrba, CSc.,
Publikace: Progress in Electromagnetic Research Symposium (PIERS). Cambridge, MA: The Electromagnetics Academy, 2016. p. 4648. ISBN 978-1-5090-6093-1.
Rok: 2016

DOI: 10.1109/PIERS.2016.7735714
Odkaz: https://doi.org/10.1109/PIERS.2016.7735714
Pracoviště: Katedra elektromagnetického pole
Anotace:
Introduction: Brain stroke is after heart attack the second main reason for sudden death in the Czech Republic. Early start of appropriate treatment is crucial for patient's perspectives. The brain stroke detection system is offering a relatively cheap diagnostic tool which could be able to distinguish two types of brain strokes: ischemic stroke and hemorrhagic one (detection of changes in permittivity and conductivity). Both of these strokes need different type of treatment. In this paper a comparison study of three types of UWB antennas through numerical simulation is performed. All three antennas are working in the frequency bandwidth 1.5-3 GHz. Methods: Antenna is very important part of brain stroke detection systems. Currently, we are using simple UWB bowtie antennas of relatively low sensitivity to detection of hemorrhagic strokes. The main task was to choose the best antenna through the sensitivity of detection. We choose three different type of antennas 1) bowtie antenna, 2) double ridge horn antenna (adopted from [2]) and 3) microstrip antenna. For numerical simulation the numerical simulator SIM4LIFE 2.0 was used. Antennas were facing to the numerical homogenous model of human brain with dielectric parameters εr = 48.9 and σ = 1.31[S/m] (at 1 GHz). At the distance 40 mm from antenna the hemorrhage represented by blood of cylindrical shape of εr = 61.1 and σ = 1.54 [S/m] (at 1 GHz) was placed. The basic configuration can be seen in Fig. 1. We observed S11 parameter differences at certain frequencies between two cases 1) without hemorrhagic stroke and 2) with hemorrhagic one. Results: The simulations show that the best antenna for stroke detection is the microstrip antenna. The sensitivity was higher by 11% (24%) against horn antenna (bowtie antenna)

Energy Parasites Trigger Oncogene Mutation

Autoři: Pokorný, Jiří, Pokorný, J., Jandová, A., Kobilková, J., prof. Ing. Jan Vrba, CSc., Vrba, J.
Publikace: International Journal of Radiation Biology. 2016, 2016(4), 1-15. ISSN 0955-3002.
Rok: 2016

DOI: 10.1080/09553002.2016.1222095
Odkaz: https://doi.org/10.1080/09553002.2016.1222095
Pracoviště: Katedra elektromagnetického pole
Anotace:
Purpose: Cancer initialization can be explained as a result of parasitic virus energy consumption leading to randomized genome chemical bonding. Materials and Methods: Analysis of experimental data on cell-mediated immunity (CMI) containing about 12,000 cases of healthy humans, cancer patients and patients with precancerous cervical lesions disclosed that the specific cancer and the non-specific lactate dehydrogenase-elevating (LDH) virus antigen elicit similar responses. The specific antigen is effective only in cancer type of its origin but the non-specific antigen in all examined cancers. CMI results of CIN patients display both healthy and cancer state. The RNA of the LDH virus parasitizing on energy reduces the ratio of coherent/random oscillations. Decreased effect of coherent cellular electromagnetic field on bonding electrons in biological macromolecules leads to elevating probability of random genome reactions. Results: Overlapping of wave functions in biological macromolecules depends on energy of the cellular electromagnetic field which supplies energy to bonding electrons for selective chemical bonds. CMI responses of cancer and LDH virus antigens in all examined healthy, precancerous and cancer cases point to energy mechanism in cancer initiation. Conclusions: Dependence of the rate of biochemical reactions on biological electromagnetic field explains yet unknown mechanism of genome mutation.

Feasibility Study of Temperature Change Detection in Phantom Using M-sequence Radar

Autoři: Fišer, O., Helbig, M., Ley, S., Sachs, J., prof. Ing. Jan Vrba, CSc.,
Publikace: 2016 10th European Conference on Antennas and Propagation. Bruxelles: The European Association on Antennas and Propagation, 2016. pp. 1-4. ISSN 2164-3342. ISBN 978-88-907018-6-3.
Rok: 2016

DOI: 10.1109/EuCAP.2016.7481310
Odkaz: https://doi.org/10.1109/EuCAP.2016.7481310
Pracoviště: Katedra elektromagnetického pole
Anotace:
In this paper we present a preliminary experimental investigation of detection of very low dielectric parameter changes caused by temperature inside a phantom. The detection measurements were performed using the M-sequence UWB radar device and homogenous gelatin breast phantom. The results show the potential of UWB sensing for noninvasive temperature determination.

Waveguide Applicator System for Head and Neck Hyperthermia Treatment

Autoři: Fišer, O., Merunka, I., prof. Ing. Jan Vrba, CSc.,
Publikace: Journal of Electrical Engineering & Technology. 2016, 11(6), 1744-1753. ISSN 1975-0102.
Rok: 2016

DOI: 10.5370/JEET.2016.11.6.1744
Odkaz: https://doi.org/10.5370/JEET.2016.11.6.1744
Pracoviště: Katedra elektromagnetického pole
Anotace:
The main purpose of this article is a complex hyperthermia applicator system design for treatment of head and neck region. The applicator system is composed of four waveguides with a stripline horn aperture and circular water bolus. The specific absorption rate (SAR) and temperature distribution from this applicator in various numerical phantom models was investigated. For used targets, the treatment planning based on the optimization process made through the SEMCAD X software is added to show the steering possibilities of SAR and thereby temperature distribution. Using treatment planning software, we proved that the SAR and temperature distribution can be effectively controlled (by amplitude and phase changing) improving the SAR and temperature target coverage approximately by 20 %. For the proposed applicator system analysis and quantitative evaluation of two parameters 25 % iso-SAR and 41°C iso-temperature contours in the treatment area with the respect to sensitive structures in treatment area were defined. To verify our simulation results, the real measurement of reflectivity coefficient as well as the temperature distribution in a homogenous phantom were performed.

Array of Spiral Applicators for Local Thermotherapy

Autoři: Vorlíček, J., Ing. Ladislav Oppl, Ph.D., prof. Ing. Jan Vrba, CSc.,
Publikace: Proceedings of PIERS 2015 in Prague. Cambridge: Electromagnetics Academy, 2015. pp. 1124-1127. ISSN 1559-9450. ISBN 978-1-934142-30-1.
Rok: 2015

Pracoviště: Katedra elektromagnetického pole
Anotace:
This article deals with the design and testing of planar microwave two-wireArchimedean spiral applicator. Applicator is designed to work on the frequency f = 434 MHz, aperture has a size of 35 mm × 35 mm and its matrix composition consists of the five applicator of the same type. In this case, aperture has a size of 100 mm × 100 mm. Design simulation and the simulations of Specific Absorption Rate distribution are created in program CST MICROWAVE STUDIO 2009. Final evaluation of construction solution is established on SIXPORT for S11 coefficient and evaluation of SAR distribution is evaluated by infrared camera FLIR P25.

Design, Evaluation and Validation of Planar Antenna Array for Breast Hyperthermia Treatment

Autoři: Fišer, O., Merunka, I., prof. Ing. Jan Vrba, CSc.,
Publikace: Proceedings of 14th Conference on Microwave Techniques, COMITE 2015. Budapešť: Institute of Electrical and Electronics Engineers Inc., 2015. pp. 33-36. ISBN 9781479981212.
Rok: 2015

DOI: 10.1109/COMITE.2015.7120228
Odkaz: https://doi.org/10.1109/COMITE.2015.7120228
Pracoviště: Katedra elektromagnetického pole
Anotace:
In this contribution we described a special modular type of a planar applicator intended to heat superficially large areas. The main goal of this proposal is to use this applicator for advanced breast cancer treatment. The applicator has an octagonal shape and operates at frequency 434 MHz. We design and optimize dimensions, source positions through electromagnetic simulations, namely one, four, six and eight elements array. These applicator arrays were mutually compared and analyzed in changes of areas enclosing by 75%, 50 % and 25 % SAR contours. The surface enclosed by 50 % SAR contour were 12 cm2 by one applicator, 14.3 cm2 by four applicators array, 36 cm2 by six applicators array and 64 cm2 by eight applicators array. For experiments we constructed one and four element array and measured reflection coefficient (-10.2 dB) and temperature distribution to the agar phantom. The surface cover by 50 % SAR contour deducted from thermograms is 15 cm2 in one applicator case and 23 cm2 in four applicators case.

Development of applicator for microwave hyperthermia system for treatment of mice

Autoři: Vrba, D., Buršík, M., Wiewegh, M., prof. Ing. Jan Vrba, CSc., Vrba, J.
Publikace: Progress in Electromagnetics Research Symposium in Prague. Cambridge: Electromagnetics Academy, 2015. pp. 2878-2881. ISSN 1931-7360. ISBN 9781934142301.
Rok: 2015

Pracoviště: Katedra elektromagnetického pole
Anotace:
In this paper, an applicator developed in [1] for focusing EM energy into a cylindrical agar phantom has been adapted for microwave hyperthermia of mice. The working frequency of the applicator stays 434 MHz. It's performance has been tested using both numerical simulation tool SEMCAD X [2] and measurements. Within the numerical simulations a high resolution anatomical model of a laboratory mouse [3] has been employed. For experimental part homogeneous agar phantoms of mouse has been prepared and a controlled microwave heating of the phantom of a laboratory mouse was performed. For this purpose the clinical microwave hyper-thermia system ALBA ON 4000, ALBA Hyperthermia System, Italy has been used.

Diseases caused by defects of energy level and loss of coherence in living cells

Autoři: Jandová, A,, Pokorný, J., Pokorný, Jiří, Kobilková, J., Nedbalová, M., Čoček, A,, Jelínek, F., prof. Ing. Jan Vrba, CSc., Vrba, J., Dohnalová, A., Kytnarová, J., Tuszynski, J.A., Foletti, A.
Publikace: Electromagnetic Biology and Medicine. 2015, 34(2), 151-155. ISSN 1536-8378.
Rok: 2015

DOI: 10.3109/15368378.2015.1036076
Odkaz: https://doi.org/10.3109/15368378.2015.1036076
Pracoviště: Katedra elektromagnetického pole
Anotace:
Human and animal diseases are brought about by pathological alterations of production, composition, and conformation of macromolecules and structures in cells. Additional contributing factors include changes in physiological states caused by disturbances of energy supply, energy transduction, energy dissipation in moving or oscillating parts, and parasitic energy consumption. Disturbances of energy states may endanger existence of the system. The cell-mediated immunity (CMI) response of T lymphocytes correlating with their adherence properties was examined using antigen prepared from the serum of inbred laboratory mice strain C3H H2k infected with lactate dehydrogenase elevating (LDH) virus. LDH virus is a parasite on the cellular energy system. Significant CMI response was elicited in T lymphocytes prepared from the blood of patients with cancer of different phenotypes, acute myocardial infarctions, schizophrenia, and recurrent spontaneous abortions in early pregnancy from unknown reasons. The CMI response is assumed to monitor transferred information about decreased levels of energy states and decoherence in the cells caused by mitochondrial malfunction, parasitic consumption, production of lactate, and possibly other disturbances. The LDH virus infection or similar pathological processes caused by different agents might be connected with the diseases and monitored by the examined CMI response. A large amount of mitoses with chromosome defects in aborted fetuses suggest increased mutability of genomes caused by defective energy states.

E-field distribution measurement system for hyperthermia applicators with LED sensor

Autoři: Merunka, I., Fišer, O., prof. Ing. Jan Vrba, CSc.,
Publikace: Proceedings of 14th Conference on Microwave Techniques, COMITE 2015. Budapešť: Institute of Electrical and Electronics Engineers Inc., 2015. pp. 30-32. ISBN 9781479981212.
Rok: 2015

DOI: 10.1109/COMITE.2015.7120227
Odkaz: https://doi.org/10.1109/COMITE.2015.7120227
Pracoviště: Katedra elektromagnetického pole
Anotace:
In this contribution we present a first version of a simple and fast system for E-field and SAR distribution measurement of hyperthermia applicators. The system consists of five main parts. These are 3D positioning system, light emitting diode (LED) sensor of electrical field (E-field), aquarium with saline solution, digital camera and image processing algorithm. LED E-field sensor is moved in front of the aperture of hyperthermia applicator while the digital camera takes pictures of the scene in appropriate cross section of the applicator. Digital image processing is then performed in order to extract intensity of light emitted from the sensor and reconstruct the final distribution of E-field. Results from this measuring procedure are compared with the results from numerical simulation.

EM exposure system with well defined dosimetry

Autoři: prof. Ing. Jan Vrba, CSc., Víšek, L., Ing. Ladislav Oppl, Ph.D., Vrba, D., Vrba, J., Vozeh, F., Barcal, J., Vannucci, L.
Publikace: Progress in Electromagnetics Research Symposium in Prague. Cambridge: Electromagnetics Academy, 2015. pp. 191-194. ISSN 1931-7360. ISBN 9781934142301.
Rok: 2015

Pracoviště: Katedra elektromagnetického pole
Anotace:
The whole-body exposure system for unrestrained mice was designed in order to analyze the influence of electromagnetic field. The setup operating at 900 MHz was designed with respect to induced uniform field, external radiation elimination, absorbed power determination, sufficient space for mice movement together with even mice exposure and costs. The main aim of this paper is to assure that the dosimetry results reached by computer simulations can be used for determination of absorbed power in the unrestrained mouse. The whole-body exposure chamber with anatomical mouse model was simulated by two different numerical methods: finite-difference-time-domain method (FDTD) and Finite Integration Technique (FIT) and its dosimetry results were compared by computed SAR values. In our contribution we will describe our first results dealing with observed biological effects of EM field, obtained by real exposures of experimental animals.

Feasibility study of microwave interstitial applicator array for treatment pancreatic cancer (Conference Paper)

Autoři: Vojáčková, L., prof. Ing. Jan Vrba, CSc., Fišer, O., Merunka, I., Červinková, K.
Publikace: Progress in Electromagnetics Research Symposium in Prague. Cambridge: Electromagnetics Academy, 2015. pp. 2613-2617. ISSN 1931-7360. ISBN 9781934142301.
Rok: 2015

Pracoviště: Katedra elektromagnetického pole
Anotace:
The aim of this paper is to check a possibility of usage of interstitial helix applicators for a treatment pancreatic cancer by microwave hyperthermia. This feasibility study is based on the simulations. The simulations were performed in the simulation program of electromagnetic field SEMCAD X for three different frequencies: 434, 915 and 2450 MHz. This paper contains the comparison SAR distribution value (Specific Absorption Rate) simulated on these three frequencies. For simulation procedure was used "High-Resolution Human Models for Simulations: Virtual Population". The final step this feasibility study was to determine the most suitable frequency for the treatment pancreatic cancer on the base of SAR value.

Measurement of electromagnetic activity of living cells

Autoři: Pokorny, J., Pokorny, J., prof. Ing. Jan Vrba, CSc., Vrba, J.
Publikace: Progress in Electromagnetics Research Symposium in Prague. Cambridge: Electromagnetics Academy, 2015. pp. 2863-2867. ISSN 1931-7360. ISBN 9781934142301.
Rok: 2015

Pracoviště: Katedra elektromagnetického pole
Anotace:
Living cells display mechanical vibrations excited by energy supply. The majority of biological molecules and structures are electrically polar and vibrations generate an electromagnetic field. Microtubules are the generating structure in eukaryotic cells. The generated electromagnetic field can be measured at the plasma membrane by a micro sensor integrated with an input amplifier and evaluated by a real time spectrum analyser controlled by computer.

Mitochondrial dysfunction and disturbed coherence: Gate to cancer

Autoři: Pokorny, J., Pokorny, J., Folleti, A., Koblikova, J., prof. Ing. Jan Vrba, CSc., Vrba, J.
Publikace: Pharmaceuticals. 2015, 8(4), 675-695. ISSN 1424-8247.
Rok: 2015

DOI: 10.3390/ph8040675
Odkaz: https://doi.org/10.3390/ph8040675
Pracoviště: Katedra elektromagnetického pole
Anotace:
Continuous energy supply, a necessary condition for life, excites a state far from thermodynamic equilibrium, in particular coherent electric polar vibrations depending on water ordering in the cell. Disturbances in oxidative metabolism and coherence are a central issue in cancer development. Oxidative metabolism may be impaired by decreased pyruvate transfer to the mitochondrial matrix, either by parasitic consumption and/or mitochondrial dysfunction. This can in turn lead to disturbance in water molecules’ ordering, diminished power, and coherence of the electromagnetic field. In tumors with the Warburg (reverse Warburg) effect, mitochondrial dysfunction affects cancer cells (fibroblasts associated with cancer cells), and the electromagnetic field generated by microtubules in cancer cells has low power (high power due to transport of energy-rich metabolites from fibroblasts), disturbed coherence, and a shifted frequency spectrum according to changed power. Therapeutic strategies restoring mitochondrial function may trigger apoptosis in treated cells; yet, before this step is performed, induction (inhibition) of pyruvate dehydrogenase kinases (phosphatases) may restore the cancer state. In tumor tissues with the reverse Warburg effect, Caveolin-1 levels should be restored and the transport of energy-rich metabolites interrupted to cancer cells. In both cancer phenotypes, achieving permanently reversed mitochondrial dysfunction with metabolic-modulating drugs may be an effective, specific anti-cancer strategy.

Study of Hot Spots by Oncological Patients with Metal Implants in Head and Neck Region

Autoři: Fišer, O., Merunka, I., Vojáčková, L., prof. Ing. Jan Vrba, CSc.,
Publikace: Progress in Electromagnetics Research Symposium in Prague. Cambridge: Electromagnetics Academy, 2015. pp. 2593-2597. ISSN 1931-7360. ISBN 9781934142301.
Rok: 2015

Pracoviště: Katedra elektromagnetického pole
Anotace:
The purpose of this contribution is to study the risk of unwanted hotspots around metallic implants in head and neck area of the new waveguide applicator system. Metallic implants may interact with the EM field. The reaction rate depends on the implants dimensions.

Suitable Use of Nanostructures in the Treatment of Tumors by the Radiofrequency Ablation Method

Autoři: Nováková, M., prof. Ing. Jan Vrba, CSc., Piksová, K.
Publikace: International Review of Electrical Engineering. 2015, 5(10), 687-693. ISSN 1827-6660.
Rok: 2015

DOI: 10.15866/iree.v10i5.6185
Odkaz: https://doi.org/10.15866/iree.v10i5.6185
Pracoviště: Katedra elektromagnetického pole
Anotace:
Radiofrequency ablation (RFA) is a minimally invasive method, suitable for treatment of irresectable primary and secondary tumors. The principle of this method is to supply electric current to the target’s centre where it causes coagulative necrosis. Electric current, generated by a radiofrequency (rf.) generator, is used for ablation. Electrodes of different shape and dimensions (according to the type of tumor tissue and lesion shape and size) are then used to optimize 3D distribution of electric current in the area to be treated. If tumor centers are of approximately spherical shape, that could be generated by the use of electrodes, then the treatment will be effective. More irregular the tumor shape is, faster the treatment effect decreases. High doses of energy are concentrated in the immediate vicinity of the applicator resulting in heat production. Considerable heat loss occurs as the transfer of thermal energy decreases rapidly with distance. Moreover, the thermal energy transfer is significantly influenced by the thermal conductivity, therefore, it depends on the conductivity parameters (including perfusion) of tissues. Thus, the resultant thermal effect may be insufficient to completely treat the predicted tumor area. Other treatment limitations are the total treatment volume and therapeutic time both limited by the maximal temperature near the end of the applicator; temperature above 105°C leads to tissue carbonization and the loss of current conduction in the treated tissue. To improve the effects of treatment methods, there are different solutions: by reducing or increasing the power source of radiofrequency energy, by influencing the spread of current or by influencing the tissue response.

UWB waveguide breast tumor detection system based on delay and sum reconstruction algorithm

Autoři: Fišer, O., Merunka, I., prof. Ing. Jan Vrba, CSc.,
Publikace: Progress in Electromagnetics Research Symposium in Prague. Cambridge: Electromagnetics Academy, 2015. pp. 1506-1509. ISSN 1931-7360. ISBN 9781934142301.
Rok: 2015

Pracoviště: Katedra elektromagnetického pole
Anotace:
The purpose of this contribution is breast malignant tumor detection through the confocal delay and sum reconstruction algorithm. The tumor signal is extracted from background and used for reconstruction. For higher accuracy the scattered signal from all four UWB waveguide antennas, which are located around the breast, were used.

Waveguide hyperthermia applicator with circular polarisation

Autoři: Merunka, I., Fišer, O., Vojáčková, L., prof. Ing. Jan Vrba, CSc.,
Publikace: Progress in Electromagnetics Research Symposium in Prague. Cambridge: Electromagnetics Academy, 2015. pp. 2589-2592. ISSN 1931-7360. ISBN 9781934142301.
Rok: 2015

Pracoviště: Katedra elektromagnetického pole
Anotace:
We dedicated this contribution to design of a circular waveguide microwave hyperthermia applicator with circular polarisation. Designing equations as well as optimization process of applicator using numerical simulator of electromagnetic field are described. Numerical simulations of specific absorption rate (SAR) and consecutive thermal simulation confirmed our assumption, that a spherical object can be better covered by SAR with an applicator with circular polarisation.

Applicator for Superficial Microwave Hyperthermia Filled with Anisotropic Dielectric Media: Numerical Investigation of Design Degrees of Freedom

Autoři: Vrba, J., Vrba, D., Wiewegh, M., prof. Ing. Jan Vrba, CSc.,
Publikace: PIERS 2014 Guangzhou. Cambridge: Electromagnetics Academy, 2014. pp. 2741-2745. ISSN 1559-9450. ISBN 978-1-934142-28-8.
Rok: 2014

Pracoviště: Katedra elektromagnetického pole
Anotace:
— In this paper properties of an rectangular-waveguide applicator (test applicator) for superficial microwave hyperthermia filled with stratified isotropic and/or anisotropic dielectric media are discussed. Man-made biaxial anisotropic material is considered here. Electric field distributions in a cross-section of the test applicator filled with anisotropic material are compared with the test applicator filled completely with water and with the one partially filled with water and partially with high permittivity materials. Furthermore, for some applicators power loss densities in the virtual phantom of muscle tissue are numerically estimated

Cancer - Pathological Breakdown of Coherent Energy States

Autoři: Pokorný, J., Pokorný, J., Kobilková, J., Jandová, J., prof. Ing. Jan Vrba, CSc., Vrba, J.
Publikace: Biophysical Reviews and Letters. 2014, 9(1), 115-133. ISSN 1793-0480.
Rok: 2014

DOI: 10.1142/S1793048013300077
Odkaz: https://doi.org/10.1142/S1793048013300077
Pracoviště: Katedra elektromagnetického pole
Anotace:
Conclusions obtained in this paper are as follows: Cancer treatment should target mitochondrial dysfunction to restore the coherent state far from thermodynamic equilibrium, apoptotic pathway, and subordination of the cell in the tissue.

High-frequency electromagnetic radiation and the production of free radicals in four mouse organs

Autoři: Barcal, J.B., Stopka, P.S., Křížová, J., prof. Ing. Jan Vrba, CSc., Vožeh, F.
Publikace: Activitas Nervosa Superior Rediviva. 2014, 1-2(56), 9-14. ISSN 1337-933X.
Rok: 2014

Pracoviště: Katedra elektromagnetického pole
Anotace:
The study was designed to evaluate the effect of high-frequency electromagnetic field (HF EMF) 900 MHz on reactive oxygen species (free radicals) production. The experimental animals (10 mice of C3H strain) were exposed to whole-body irradiation over 14 days (3 hours daily) in a special exposure chamber with the possibility of a specific absorption rate measurement. The 10 control animals were kept in an analogous position (inside the chamber) but in turn-off mode. After the last exposure, four tissue samples (brain, liver, heart, kidney) were immediately stored in liquid nitrogen and transported to a special electron paramagnetic (spin) resonance spectroscopy measurement. In all four tissue samples of irradiated animals, a statistically significant increase (p<0.0025) of hydroxyl radicals concentration was found. These results confirm previous experiments with indirect assessment of free radicals overproduction (made by enzymatic systems depiction) and strongly support the hypothesis about the possible mechanism and/or harmful effect of long-term HF EMF exposure.

Interstitial Applicators for Breast Cancer Treatment by Microwave Thermoablation

Autoři: Vojáčková, L., Merunka, I., Fišer, O., prof. Ing. Jan Vrba, CSc.,
Publikace: 24th International Conference Radioelektronika 2014. Bratislava: Slovak University of Technology, 2014. ISBN 978-1-4799-3715-8.
Rok: 2014

DOI: 10.1109/Radioelek.2014.6828456
Odkaz: https://doi.org/10.1109/Radioelek.2014.6828456
Pracoviště: Katedra elektromagnetického pole
Anotace:
In this paper we studied the possibility of utilization of interstitial applicators virtually organized in several configurations for the treatment of the breast cancer by microwave thermo ablation. The interstitial applicators used in this work are applicators of the helix type. The specified operating frequency considered for the here presented applicators is 2.45 GHz. For calculation of SAR and temperature characteristics created by these applicators a simulator of electromagnetic field SEMCAD X was used. In our simulations a model of the breast tissue that includes a sphere with tumor parameters inside was used. We concentrated on examining a distribution of SAR value in the area which has parameters equivalent to the breast tumor mainly.

Matrix of Interstitial Applicators for MicrowaveThermoablation

Autoři: Vojáčková, L., prof. Ing. Jan Vrba, CSc., Vrbová, B.
Publikace: Conference Proceedings of EuCAP 2014. Bruxelles: The European Association on Antennas and Propagation, 2014. pp. 2191-2194. ISBN 978-88-907018-4-9.
Rok: 2014

Pracoviště: Katedra elektromagnetického pole
Anotace:
This work presents results dealing with the design of the matrix of interstitial applicators, its numeric simulation, optimization, realization and subsequent verification of the characteristics for the microwave thermoablation. The operating frequency is 2.45 GHz. The aim was to choose an appropriate construction and type of studied applicators with respect to the homogeneity of SAR (resp. temperature) characteristics and also to the therapeutically effective profile.

Measurement of Temperature Increase of Metal Hip Replacements During Magnetic Resonance Imaging

Autoři: Wiewegh, M., prof. Ing. Jan Vrba, CSc.,
Publikace: PIERS 2014 Guangzhou. Cambridge: Electromagnetics Academy, 2014. pp. 2746-2749. ISSN 1559-9450. ISBN 978-1-934142-28-8.
Rok: 2014

Pracoviště: Katedra elektromagnetického pole
Anotace:
In this paper measurements of temperature increase of three dierent hip replace- ments during MRI were carried out. The hip replacements were embedded in an agar phantom which mimics dielectric properties of muscle tissue and were placed into a MRI system with the static magnetic eld intensity of B0 = 1:5 T. The MRI of the samples took in total 20 minutes. Thermograms of the hip replacements were taken with a thermographic camera in two dierent time instances.

Microwave Hyperthermia Treatment of Neck Cancer Using Eight UWB Antennas

Autoři: Merunka, I., Fišer, O., Vojáčková, L., prof. Ing. Jan Vrba, CSc., Vrba, J., Vrba, D.
Publikace: European Microwave Week 2014 Conference Proceedings. London: Horizon House Publications, 2014. pp. 790-793. ISBN 978-2-87487-034-7.
Rok: 2014

DOI: 10.1109/EuMC.2014.6986553
Odkaz: https://doi.org/10.1109/EuMC.2014.6986553
Pracoviště: Katedra elektromagnetického pole
Anotace:
We analyse the application of an ultra wideband (UWB) balanced antipodal Vivaldi antenna to hyperthermia head and neck cancer treatment in this paper. Balanced antipodal Vivaldi antenna was primary developed for microwave imaging. The shape of isosurface, where specific absorption rate (SAR) decreases to 25% of its maximal value of one antenna, is observed in simple rectangular phantom at frequency 915 MHz for three different distances between antenna and phantom. Two different antenna configurations are then considered. Eight antenna configuration, where eight antennas are equidistantly placed in circle in one plane and three antenna configuration, where only three nearest antennas to the tumour region are placed in smaller circle with centre in the tumour region. Optimization of SAR distribution and thermal simulation was performed after electromagnetic simulation. Although thyroid gland tissue was covered by SAR quite well, its temperature did not rise. It confirms the importance of thermal simulation in treatment planning procedure.

Microwave Thermotherapy: Hot-Spots Induced by Surface EM Waves

Autoři: prof. Ing. Jan Vrba, CSc., Vrbová, B., Vrba, J., Vrba, D.
Publikace: Proceedings of 31st URSI GASS. Piscataway: IEEE, 2014. ISBN 978-1-4673-5225-3.
Rok: 2014

Pracoviště: Katedra elektromagnetického pole
Anotace:
The paper deals with analytical and numerical model for evaluation of the hot-spots induced by surface EM waves during treatment of cancer by microwave hyperthermia. Experimental evaluation is described as well.

Microwaves in Medical Diagnostics and Treatment

Autoři: prof. Ing. Jan Vrba, CSc., Ing. Ladislav Oppl, Ph.D., Vrbová, B., Vrba, D., Havelka, D., Červinková, K., Vojáčková, L., Merunka, I., Fišer, O.
Publikace: 24th International Conference Radioelektronika 2014. Bratislava: Slovak University of Technology, 2014. pp. 1-6. ISBN 978-1-4799-3715-8.
Rok: 2014

DOI: 10.1109/Radioelek.2014.6828405
Odkaz: https://doi.org/10.1109/Radioelek.2014.6828405
Pracoviště: Katedra elektromagnetického pole
Anotace:
Paper deals with a description of research activities in the field of Microwave Medical Diagnostics and Treatment done at the Dept. of EM Field, Czech Technical University (CTU) in Prague. History of these activities goes to year 1981, when the first apparatus for microwave hyperthermia cancer treatment has been developed at CTU and one year later started to be used for oncological patient treatments at Institute of Radiation Oncology (Hospital Bulovka in Prague). In present time we have several areas of research activities dealing with applications of microwave theory, technique and technologies in medical diagnostics and therapy. Future trends in medical applications of microwave technique and technology can be seen in development of new diagnostic and imaging methods based on microwaves. A significant importance for the future can be identified for the following microwave methods: Tomography, Radiometry, Measurement of complex permittivity, Imaging in the Terahertz waves band and Diagnostic radars.

Oriented Array of Waveguide Applicators for Local Thermotherapy

Autoři: Fišer, O., prof. Ing. Jan Vrba, CSc.,
Publikace: Conference Proceedings of EuCAP 2014. Bruxelles: The European Association on Antennas and Propagation, 2014. pp. 1818-1821. ISBN 978-88-907018-4-9.
Rok: 2014

DOI: 10.1109/EuCAP.2014.6902148
Odkaz: https://doi.org/10.1109/EuCAP.2014.6902148
Pracoviště: Katedra elektromagnetického pole
Anotace:
The main topic of this contribution is the design, numeric simulation and optimization of a matrix 4 of applicators for local thermotherapy. Applicators are based on water filled waveguides with strip line horn aperture. The working frequency is 434 MHz. The work is aimed at optimization of 3D SAR homogeneity, effective penetration depth of SAR and reflection coefficient. Applicators may have different polarizations and we investigated the effects of the combination of polarizations of the applicators on the resulting 3D SAR distribution. We rotated individual applicators step by step by 90 degrees (by this activity we changed the individual polarization of applicators).

Space Distribution of SAR and Temperature in Human Body Model with Tumor Using Waveguide Applicator Array

Autoři: Fišer, O., Merunka, I., Vojáčková, L., prof. Ing. Jan Vrba, CSc.,
Publikace: European Microwave Week 2014 Conference Proceedings. London: Horizon House Publications, 2014. pp. 484-487. ISBN 978-2-87487-034-7.
Rok: 2014

DOI: 10.1109/EuMC.2014.6986476
Odkaz: https://doi.org/10.1109/EuMC.2014.6986476
Pracoviště: Katedra elektromagnetického pole
Anotace:
The way to treat tumors in head and neck region is the main aim of this work. For this purpose we used array of waveguide applicators working on frequency 434 MHz. Characteristics of used applicator array tested through the EM field simulator SEMCAD X on numerical model and model made from CT scans. We observed SAR and temperature distribution in tumor and sensitive tissues. For better results we optimized SAR distribution and tried to focus energy to tumor. This contribution shows good control of SAR distribution patterns and offers a solution for patients with large tumors.

Study of Superposition of SAR Distribution Created by External and Interstitial Applicator

Autoři: Vrbová, B., prof. Ing. Jan Vrba, CSc.,
Publikace: Conference Proceedings of EuCAP 2014. Bruxelles: The European Association on Antennas and Propagation, 2014. p. 1802-1804. ISBN 978-88-907018-4-9.
Rok: 2014

Pracoviště: Katedra elektromagnetického pole
Anotace:
This paper deals with a study of the shapes of SAR distribution created by a superposition of EM expositions done contemporary by external and interstitial applicator. Three different cases are numerically and experimentally studied and compared in this paper. In the first case we describe the shape of SAR distribution created only by monopole antenna, which represents interstitial applicator. In the second case we discuss the SAR distribution created only by external microwave stripline type applicator with TEM mode. In the last case we describe a superposition of SAR distribution created by EM expositions done contemporary by external and interstitial applicator. Both applicators are excited at the same frequency (f = 434 MHz), power and phase. Numerical results of SAR distribution are compared with those obtained experimentally for all three cases, very good correlation between simulations and measurements can be seen.

System for Animal EM Exposure with well Defined Dosimetry

Autoři: prof. Ing. Jan Vrba, CSc., Vrba, D., Vožeh, F., Barcal, J., Vannucci, L., Vrba, J.
Publikace: Proceedings of 31st URSI GASS. Piscataway: IEEE, 2014. ISBN 978-1-4673-5225-3.
Rok: 2014

DOI: 10.1109/URSIGASS.2014.6930071
Odkaz: https://doi.org/10.1109/URSIGASS.2014.6930071
Pracoviště: Katedra elektromagnetického pole
Anotace:
The whole-body exposure system for unrestrained mice was designed in order to analyze the influence of electromagnetic field. The setup operating at 900MHz was designed with respect to induced uniform field, external radiation elimination, absorbed power determination, sufficient space for mice movement together with even mice exposure and costs. The main aim of this paper is to assure that the dosimetry results reached by computer simulations can be used for determination of absorbed power in the unrestrained mouse. The whole-body exposure chamber with anatomical mouse model was simulated by two different numerical methods: finite-difference-time-domain method (FDTD) and Finite Integration Technique (FIT) and its dosimetry results were compared by computed SAR values. In our contribution we will describe our first results dealing with observed biological effects of EM field, obtained by real exposures of experimental animals.

Theory and Design of Microwave Applicator Coupled to Biological Tissue Based on Impedance Matching

Autoři: Vrbová, B., prof. Ing. Jan Vrba, CSc.,
Publikace: 24th International Conference Radioelektronika 2014. Bratislava: Slovak University of Technology, 2014. pp. 1-4. ISBN 978-1-4799-3715-8.
Rok: 2014

Pracoviště: Katedra elektromagnetického pole
Anotace:
Our paper studies design of m applicator based on impedance matching. deal with a topology and signal flow gr coupled to biological tissue.

Thermoablation for Breast Cancer Treatment Using

Autoři: Vojáčková, L., Merunka, I., Fišer, O., prof. Ing. Jan Vrba, CSc.,
Publikace: European Microwave Week 2014 Conference Proceedings. London: Horizon House Publications, 2014. ISBN 978-2-87487-034-7.
Rok: 2014

DOI: 10.1109/EuMC.2014.6986554
Odkaz: https://doi.org/10.1109/EuMC.2014.6986554
Pracoviště: Katedra elektromagnetického pole
Anotace:
In this paper we studied the possibilities of usage of interstitial applicators for the breast cancer treatment by microwave thermoablation. The applicators used in this work are the helix type and the operating frequency was 2.45GHz. For here described simulations two types of breast phantoms were used. The interstitial applicators, virtually organized in several configurations, were gradually inserted into these phantoms. The first model of breast was simply created by spherical segment. It was formed by three parts: a homogeneous breast tissue, skin and a spherical tumour. The second breast phantom was derived from magnetic resonance images (MRIs) and includes more parts which are anatomically realistic. The phantom includes a bit more complex shape of the tumour. For calculation of SAR characteristics created by these applicators a simulator of electromagnetic field SEMCAD X was used. A distribution of SAR value was especially monitored in the area where the breast tumour was placed. Finally we could compare the differences between the simplified breast model and the MRI-derived model.

Two-channel Measurement of the Ultra-weak Photon emission from a yeast culture during its growth

Autoři: Červinková, K., Nerudová, M., Cifra, M., Hašek, J., prof. Ing. Jan Vrba, CSc.,
Publikace: 24th International Conference Radioelektronika 2014. Bratislava: Slovak University of Technology, 2014. ISBN 978-1-4799-3715-8.
Rok: 2014

Pracoviště: Katedra elektromagnetického pole
Anotace:
The paper deals with a measurement of the spontaneous ultra-weak photon emission from wild type cells of yeast Saccharomyces cerevisiae during their growth. The objective of the work was to obtain a temporal development of optical signals from yeast samples utilizing two photomultiplier tubes with different properties.

Utilization of Waveguide Applicators Combination for Electromagntic Field Focusing

Autoři: Fišer, O., Merunka, I., Vojáčková, L., prof. Ing. Jan Vrba, CSc.,
Publikace: 24th International Conference Radioelektronika 2014. Bratislava: Slovak University of Technology, 2014. ISBN 978-1-4799-3715-8.
Rok: 2014

DOI: 10.1109/Radioelek.2014.6828446
Odkaz: https://doi.org/10.1109/Radioelek.2014.6828446
Pracoviště: Katedra elektromagnetického pole
Anotace:
The main goal of this article is to report on electromagnetic energy targeting (represented SAR) to muscle tissue affected by tumor. By the combination of four and six applicators we want to hit the most part of the tumor. We developed water filled waveguide applicator with stripline horn aperture suitable to get maximum SAR to the malignant tissue. To find suitable applicator position we used the EM field simulator SEMCAD Aletsch 14.8 from SPEAG, Schmidt & Partner Engineering AG, Switzerland. We used the mathematical software MATLAB to view simulation results. In the first part of this article we show the distribution of EM energy to the homogenous phantom with the dielectric parameters of human muscle in which we placed inhomogeneity as malignant tissue. We describe distribution of SAR values in phantoms with different widths. Further, we made SAR field optimization based on Generalized eigenvalue approach with the EM field simulator SEMCAD X. Then we used thermal simulation to show the temperature distribution. In the second part of this contribution we did the same simulation but we exchanged homogenous muscle phantom by heterogeneous human model.

Zeroth-order Mode Resonator Metamaterial Applicators for Superficial and Deep Local Microwave Hyperthermia

Autoři: Vrba, D., Vrba, J., Wiewegh, M., prof. Ing. Jan Vrba, CSc.,
Publikace: PIERS 2014 Guangzhou. Cambridge: Electromagnetics Academy, 2014. pp. 2750-2752. ISSN 1559-9450. ISBN 978-1-934142-28-8.
Rok: 2014

Pracoviště: Katedra elektromagnetického pole
Anotace:
Paper deals with our new results in the field of applicators used for microwave regional thermotherapy, like, e.g., cancer treatment, physiotherapy, etc.. New type of applicator based on Metamaterial technology especially with zeroth order resonances will be introduced. The main aim of this work is to verify whether EM wave penetrating into the biological tissue can have good SAR homogeneity and depth of penetration approaching to theoretical limit.

Application of EM Field in Medicine

Autoři: prof. Ing. Jan Vrba, CSc., Ing. Ladislav Oppl, Ph.D., Vrbová, B., Vorlíček, J., Vrba, J., Vrba, D.
Publikace: Progress In Electromagnetics Research Symposium 2013 Taipei. Cambridge: Electromagnetics Academy, 2013. pp. 1240-1243. ISSN 1559-9450. ISBN 978-1-934142-24-0.
Rok: 2013

Pracoviště: Katedra elektromagnetického pole
Anotace:
Medical applications of microwaves (i.e., using microwave energy and microwave technique and technology for therapeutical purposes) are a quite new and a very rapidly devel- oping ¯eld. Microwave thermotherapy is being used in medicine for the cancer treatment and treatment of some other diseases since early eighties. In this contribution, we would like to oer general overview of present activities in the Czech Republic, i.e., clinical applications and results, technical aspects of thermo therapeutic equipment and last but not least, prospective diagnostics based on microwave principals ant technology and instrumentation.

Biophysical Insights into Cancer Transformation and Treatment

Autoři: Pokorný, J., Foletti, A., Kobilková, J., Jandová, A., prof. Ing. Jan Vrba, CSc., Vrba, J., Nedbalová, M., Čoček, A., Danani, A., Tuszyński, J. A.
Publikace: Scientific World Journal. 2013, 2013 ISSN 1537-744X.
Rok: 2013

DOI: 10.1155/2013/195028
Odkaz: https://doi.org/10.1155/2013/195028
Pracoviště: Katedra elektromagnetického pole
Anotace:
Biological systems are hierarchically self-organized complex structures characterized by nonlinear interactions. Biochemical energy is transformed into work of physical forces required for various biological functions. We postulate that energy transduction depends on endogenous electrodynamic fields generated by microtubules. Microtubules and mitochondria colocalize in cells with microtubules providing tracks for mitochondrial movement. Besides energy transformation, mitochondria form a spatially distributed proton charge layer and a resultant strong static electric field, which causes water ordering in the surrounding cytosol. These effects create conditions for generation of coherent electrodynamic field. The metabolic energy transduction pathways are strongly affected in cancers. Mitochondrial dysfunction in cancer cells (Warburg effect) or in fibroblasts associated with cancer cells (reverse Warburg effect) results in decreased or increased power of the generated electromagnetic field, respectively, and shifted and rebuilt frequency spectra. Disturbed electrodynamic interaction forces between cancer and healthy cells may favor local invasion and metastasis. A therapeutic strategy of targeting dysfunctional mitochondria for restoration of their physiological functions makes it possible to switch on the natural apoptotic pathway blocked in cancer transformed cells. Experience with dichloroacetate in cancer treatment and reestablishment of the healthy state may help in the development of novel effective drugs aimed at the mitochondrial function.

EM Field and Biological Systems Interactions

Autoři: prof. Ing. Jan Vrba, CSc.,
Publikace: Progress In Electromagnetics Research Symposium 2013 Taipei. Cambridge: Electromagnetics Academy, 2013. pp. 175-178. ISSN 1559-9450. ISBN 978-1-934142-24-0.
Rok: 2013

Pracoviště: Katedra elektromagnetického pole
Anotace:
Research of interactions between em feld and biological systems is of growing interests elsewhere. Also here in czech republic there are several groups working in this feld, often in international co-operations. We will describe here mainly basic technical equipment developed for 5 different research projects in the discussed area of interactions of em feld and biological systems.

EM Field based Microwave Technologies in Medicine

Autoři: prof. Ing. Jan Vrba, CSc., Vrbová, B.
Publikace: Proceedings of the 7th European Conference on Antennas and Propagation (EUCAP 2013). Piscataway: IEEE, 2013. pp. 3013-3015. ISBN 978-88-907018-3-2.
Rok: 2013

Pracoviště: Katedra elektromagnetického pole
Anotace:
Medical applications of microwaves (i.e. a possibility to use microwave energy and/or microwave technique and technology for therapeutical purposes) are a quite new and a very rapidly developing field. Microwave thermotherapy is being used in medicine for the cancer treatment and treatment of some other diseases since early eighties. In this contribution we would like to offer general overview of present activities in the Czech Republic, i.e. clinical applications and results, technical aspects of thermo therapeutic equipment and last but not least, prospective diagnostics based on microwave principals ant technology and instrumentation.

Microwave Thermotherapy: Study of Hot-Spots Induced by Electromagnetic Surface Waves

Autoři: prof. Ing. Jan Vrba, CSc., Vrbová, B., Vrba, D., Vrba, J.
Publikace: Proceedings of the 7th European Conference on Antennas and Propagation (EUCAP 2013). Piscataway: IEEE, 2013. pp. 3125-3126. ISBN 978-88-907018-3-2.
Rok: 2013

Pracoviště: Katedra elektromagnetického pole
Anotace:
This paper is a contribution to theory of microwave applicators used e.g. in cancer treatment by electromagnetically induced hyperthermia, but discussed problems can occur in microwave thermotherapy in general. Paper deals with a study of mechanism of excitations of surface waves propagating around the treated area - one kind of parasitic effects, which can significantly complicate real treatment of patients (these superficial waves can create superficial hot spots outside treated area). Appropriate treatment planning by aid of numerical simulations of SAR distribution can prevent such cases. In this paper we will demonstrate a possibility to eliminate excitations of surface waves by optimization of water bolus shape and dimensions.

Perspektivní aplikace mikrovlnné techniky v medicíně

Autoři: prof. Ing. Jan Vrba, CSc.,
Publikace: RADIOKOMUNIKACE 2013 - sborník přednášek. Pardubice: UNIT, 2013. pp. 221-236. ISBN 978-80-905345-2-0.
Rok: 2013

Pracoviště: Katedra elektromagnetického pole
Anotace:
V článku jsou prezentovány perspektivy technického rozvoje mikrovlnné termoterapie. Pozornost je věnována fyzikálním a technickým principům, popisu potřebné soupravy a funkci jejich jednotlivých prvků. Dále jsou zde zmíněny tři hlavní směry budoucího technického rozvoje mikrovlnné termoterapie, tj. jednak metody návrhu nových aplikátorů, dále modelové výpočty rozložení SAR a teplotního rozložení v léčené oblasti pacientova těla, v neposlední řadě pak metody pro neinvazivní měření teploty v léčené oblasti. Článek je též zaměřen na přehled nových lékařských diagnostických metod vycházejících z interakce EM pole s biologickými systémy, např. mikrovlnnou tomografii, mikroclnnou radiometrii, užití terahertzových vln a měření komplexní permitivity. Cílem článku je popis principů a základní teorie výše zmíněnych metod. Lze očekávat, že v blízké budoucnosti by některé z těchto metod mohly být dovedeny do stádia klinických aplikací.

Thermoablation for Breast Cancer Treatment Using Microwave Interstitial Helix Applicators

Autoři: Vojáčková, L., Merunka, I., Fišer, O., prof. Ing. Jan Vrba, CSc.,
Publikace: 43rd European Microwave Conference - European Microwave Week 2013 Conference Proceedings. Louvain-la-Neuve: European Microwave Association (EuMA), 2013. p. 794-797. ISSN 2325-0305. ISBN 978-2-87487-031-6.
Rok: 2013

Pracoviště: Katedra elektromagnetického pole
Anotace:
In this paper we studied the possibilities of usage of interstitial applicators for the breast cancer treatment by microwave thermoablation. The applicators used in this work are the helix type and the operating frequency was 2.45GHz. For here described simulations two types of breast phantoms were used. The interstitial applicators, virtually organized in several configurations, were gradually inserted into these phantoms. The first model of breast was simply created by spherical segment. It was formed by three parts: a homogeneous breast tissue, skin and a spherical tumour. The second breast phantom was derived from magnetic resonance images (MRIs) and includes more parts which are anatomically realistic. The phantom includes a bit more complex shape of the tumour. For calculation of SAR characteristics created by these applicators a simulator of electromagnetic field SEMCAD X was used. A distribution of SAR value was especially monitored in the area where the breast tumour was placed. Finally we could compare the differences between the simplified breast model and the MRI-derived model.

Ultra Weak Photon Emission from Saccharomyces Cerevisiae

Autoři: Červinková, K., Nerudová, M., Cifra, M., Hašek, J., prof. Ing. Jan Vrba, CSc.,
Publikace: Proceedings of PIERS 2013 in Stockholm. Cambridge: Electromagnetics Academy, 2013. pp. 114-117. ISSN 1559-9450. ISBN 978-1-934142-26-4.
Rok: 2013

Pracoviště: Katedra elektromagnetického pole
Anotace:
This paper introduces the basic concept of measuring spontaneous ultra weak photon emission from yeast Saccharomyces cerevisiae. The objective of the work is a comparison of ultra weak photon emission from two mitochondrial mutants which di®er in an activity of their energy-generatingpathway. Photon emission has been measured in a visible range utilizing sensitive photomutliplier tube.

Waveguide-based Applicators for Superficial Hyperthermia Treatment: is Tuning Really Required?

Autoři: Dřížďal, T., Paulides, M.M., prof. Ing. Jan Vrba, CSc., van Rhoon, G. C.
Publikace: Journal of Electromagnetic Waves and Applications. 2013, 6(27), 682-690. ISSN 0920-5071.
Rok: 2013

DOI: 10.1080/09205071.2013.762609
Odkaz: https://doi.org/10.1080/09205071.2013.762609
Pracoviště: Katedra elektromagnetického pole
Anotace:
Waveguide-based applicators are used for hyperthermia treatment of superficial tumors, e.g. chest wall recurrences. During superficial hyperthermia treatment (SHT), the patient is in the near field of these antennas, so its radiating properties may vary. To maximize the transfer power from generators towards treatment area, waveguide-based applicators usually feature means for tuning the applicators. The purpose of this study was to investigate whether waveguide-based applicators for SHT really require such tuning. Hereto, we designed and optimized a waveguide lucite applicator at 434 MHz, applying a muscle phantom and a layered (skin, fat and muscle) phantom to mimic the patient. Applicator performance was measured for different water bolus temperatures and temperatures of the water circulating the applicator by studying impedance matching. dB was measured for nine locations at the skin of a volunteer and three different water bolus temperatures. We conclude that tuning of waveguide-based applicators is not required when the applicator is properly designed.

Design of a Wideband Multi-channel System for Time Reversal Hyperthermia

Autoři: Dobšiček-Trefná, H., Togni, P., Shiee, R., prof. Ing. Jan Vrba, CSc., Persson, M.
Publikace: International Journal of Hyperthermia. 2012, 28(2), 175-183. ISSN 0265-6736.
Rok: 2012

DOI: 10.3109/02656736.2011.641655
Odkaz: https://doi.org/10.3109/02656736.2011.641655
Pracoviště: Katedra elektromagnetického pole
Anotace:
To design and test a wideband multi-channel amplifier system for time reversal (TR) microwave hyperthermia, operating in the frequency range 300 MHz-1 GHz, enabling operation in both pulsed and continuous wave regimes. This is to experimentally verify that adaptation of the heating pattern with respect to tumour size can be realised by varying the operating frequency of the antennas and potentially by using Ultra-wideband (UWB) pulse sequences instead of pure harmonic signals. Materials and methods: The proposed system consists of 12 identical channels driven by a common reference signal. The power and phase settings are applied with resolutions of 0.1W and 0.1 degrees, respectively. Using a calibration procedure, the measured output characteristics of each channel are interpolated using polynomial functions, which are then implemented into a system software algorithm driving the system feedback loop. Results: The maximum output power capability of the system varies with frequency, between 90 and 135W with a relative power error of +/- 6%. A phase error in the order of +/- 4 degrees has been achieved within the entire frequency band. Conclusions: The developed amplifier system prototype is capable of accurate power and phase delivery, over the entire frequency band of the system. The output power of the present system allows for an experimental verification of a recently developed TR-method on phantoms or animals. The system is suitable for further development for head and neck tumours, breast or extremity applications.

Evaluation of Homogeneity of SAR Distribution of Array of TEM Mode Applicators

Autoři: Vrbová, B., prof. Ing. Jan Vrba, CSc.,
Publikace: Proceedings of the 6th European Conference on Antennas and Propagation (EUCAP 2012). Piscataway: IEEE, 2012. pp. 1091-1094. ISBN 978-1-4577-0918-0.
Rok: 2012

DOI: 10.1109/EuCAP.2012.6206458
Odkaz: https://doi.org/10.1109/EuCAP.2012.6206458
Pracoviště: Katedra elektromagnetického pole
Anotace:
This paper is a contribution to a the applicators to be used for microwave hyper treatment. In more details this paper deals wit an evaluation of homogeneity of SAR dis phantom for its changing radius. Discussed SA this case created by EM field exposure don microwave stripline type TEM mode applic type.

Intracavitary Helix Applicator to Be Used for BPH and for Prostate Cancer Treatments

Autoři: prof. Ing. Jan Vrba, CSc., Vrbová, B., Lungariello, B., Franconi, C.
Publikace: Proceedings of the 6th European Conference on Antennas and Propagation (EUCAP 2012). Piscataway: IEEE, 2012. pp. 3655-3658. ISBN 978-1-4577-0918-0.
Rok: 2012

DOI: 10.1109/EuCAP.2012.6206388
Odkaz: https://doi.org/10.1109/EuCAP.2012.6206388
Pracoviště: Katedra elektromagnetického pole
Anotace:
First part of this paper deals with new results in area of intracavitary microwave applicators which can be used e.g. for prostate cancer treatment and for Benign Prostatic Hyperplasia (BPH) treatment as well. And for some other intracavitary treatment as well. Main aim of this paper is to verify and thus support experimental results given in published paper: "Prospects for radiofrequency hyperthermia applicator research. I-Preoptimised prototypes of endocavitary applicators with matching interfaces for prostate hyperplasia and cancer treatments", this time by EM simulations of SAR distribution in the treated area. Contribution of this paper is based on comparisons of EM field simulations results vs. experimental evaluations. Second part of this paper consists of design of microwave intracavitary applicator which works at frequency 2450 MHz and can be used in treatment of cardiac arrhythmias.

Microwave Thermotherapy in Cancer Treatment: Evaluation of Homogeneity of SAR Distribution

Autoři: Vrbová, B., prof. Ing. Jan Vrba, CSc.,
Publikace: Progress In Electromagnetics Research. 2012, 129 181-195. ISSN 1559-8985.
Rok: 2012

Pracoviště: Katedra elektromagnetického pole
Anotace:
Medical applications of microwaves (i.e. a possibility to use microwave energy and/or microwave technique and technology for therapeutical purposes) are a quite new and very rapidly developing field. Microwave thermotherapy is being used in medicine for cancer treatment and treatment of some other diseases since early eighties. This paper is a contribution to a theory of phase array applicators to be used for a microwave thermotherapy (microwave hyperthermia) in a cancer treatment. It deals with a study and theoretical evaluation of homogeneity of SAR distribution in cylindrical agar phantom for several different values of its radius. Discussed SAR distribution is in our case created by simulations of EM field exposure done by aid of four microwave stripline type TEM mode applicators of the same type.

Mitochondrial Metabolism - Neglected Link of Cancer Transformation and Treatment

Autoři: Pokorný, J., Jandová, A., Nedbalová, M., Jelínek, F., Cifra, M., Kučera, O., Havelka, D., prof. Ing. Jan Vrba, CSc., Vrba, J., Čoček, A., Kobilková, J.
Publikace: Prague Medical Report. 2012, 113(2), 81-94. ISSN 1214-6994.
Rok: 2012

Pracoviště: Katedra elektromagnetického pole
Anotace:
Physical processes in living cells were not taken into consideration among the essentials of biological activity, regardless of the fact that they establish a state far from thermodynamic equilibrium. In biological system chemical energy is transformed into the work of physical forces for various biological functions. The energy transformation pathway is very likely connected with generation of the endocenous electrodynamic field as suggested by experimentally proved electrodynamic activity of biological systems conncted with mitochondrial and microtubule functions. Besides production of ATP and GTP (adenosine and guanosine triphosphate) mitochondria form a proton space charge layer, strong static electric field, and water ordering around them in cytosol - that are necessary conditions for generation of coherent electrodynamic field by microtubules.

Targeting mitochondria for cancer treatment

Autoři: Pokorny, J., Cifra, M., Jandova, A., Kučera, O., Srobar, F., prof. Ing. Jan Vrba, CSc., Vrba, J., Kobilkova, J.
Publikace: EUROPEAN JOURNAL OF ONCOLOGY. 2012, 17(1), 23-36. ISSN 1128-6598.
Rok: 2012

Pracoviště: Katedra elektromagnetického pole
Anotace:
The paper is aimed to overview the published papers for analysis of the cancer treatment by restoration of normal physiological processes, in particular electromagnetic activity and apoptotic function of glycolytic phenotype cancer cells. Achievement of this target is based on estimation of the treatment based on bringing back normal mitochondrial function through inhibition of molecules (kinases) blocking the pyruvate pathway using dichloroacetate (DCA) or drugs with similar properties. This method is supported by considerable in vitro and in vivo experience by DCA treatment even in humans. Opening pyruvate pathway restores the proton space charge layer, the strong static electric field around mitochondria, ordering of water, and induction of strong non-linearity of microtubule electrically polar oscillations. Normal level of excitation of oscillations dependent on energy liberated from mitochondria and low damping keeps running physical processes regulated by electromagnetic field. DCA may act on a wide spectrum of cancers. Cancer cells might be brought back to a normal healthy state or be subject to apoptosis by DCA or a similar drug treatment. Clinical trials should test this method, verify the results, determine effectiveness, and assess adjuvant treatment methods. Experience with DCA would accumulate experimental data for development of novel drugs for cancer treatment through restoring the mitochondrial function.

Visualization of Microwave Exposure in Industrial and Medical Applications

Autoři: Vydra, T., Havelka, D., prof. Ing. Jan Vrba, CSc.,
Publikace: Proceedings of the 6th European Conference on Antennas and Propagation (EUCAP 2012). Piscataway: IEEE, 2012. pp. 2114-2117. ISBN 978-1-4577-0918-0.
Rok: 2012

DOI: 10.1109/EuCAP.2012.6205938
Odkaz: https://doi.org/10.1109/EuCAP.2012.6205938
Pracoviště: Katedra elektromagnetického pole
Anotace:
Field of microwave applications is expanding very rapidly and it already encompasses very wide spectrum of common and well developed medical and industrial procedures. It is very important for further research that there are reliable means of analyzing effects of electromagnetic field on various materials in real-time. In this paper we present our design approach of microwave applicator for visualization purposes. We also present results and their interpretation.

Ablation Applicator for Destructive Hyperthermia Treatment

Autoři: Vydra, T., prof. Ing. Jan Vrba, CSc.,
Publikace: Journal of Physics: Conference Series. 2011, 2011(329), ISSN 1742-6588.
Rok: 2011

DOI: 10.1088/1742-6596/329/1/012035
Odkaz: https://doi.org/10.1088/1742-6596/329/1/012035
Pracoviště: Katedra elektromagnetického pole
Anotace:
This work is a preliminary research which is opening a field of examination of this complex clinic method (i.e. treatment using ablation applicators). Although it is established in many medical facilities its effects were not analyzed thoroughly and there are many unknown factors which can affect patients in clinical practice. We aim to bring new analysis methods which can simply and clearly determine how the tissue in the treated area will be affected and we want to inspect and overcome potential risks connected to this medical method.

An overview of Microwave Systems used for SAR Evaluation and Inspecting Effects in Biological Tissue

Autoři: Vydra, T., Havelka, D., Víšek, L., prof. Ing. Jan Vrba, CSc.,
Publikace: Sborník 9. česko-slovenské konference. Ostrava: VŠB, 2011. pp. 171-173. ISBN 978-80-248-2475-8.
Rok: 2011

Pracoviště: Katedra elektromagnetického pole
Anotace:
The field of microwave applications is expanding very rapidly and it already encompasses very wide spectrum of common and well developed medical and industrial procedures. It is very important for further research that there are reliable means of analyzing effects of electromagnetic field on biological material in real-time. In this paper we present our design approach of microwave applicator for visualization purposes. We also present results and their interpretation.

Applicators for Research of Biological Effects of EM Field

Autoři: prof. Ing. Jan Vrba, CSc., Víšek, L., Ing. Ladislav Oppl, Ph.D., Vanucci, L.
Publikace: PIERS 2011 Marrakesh Proceedings. Cambridge, MA: The Electromagnetics Academy, 2011. pp. 1822-1824. ISSN 1559-9450. ISBN 978-1-934142-16-5.
Rok: 2011

Pracoviště: Katedra elektromagnetického pole
Anotace:
Research of interactions between EM field and biological systems is of growing interests elsewhere. Also here in czech republic there are several groups working in this field, often in international co-operations. We will describe here mainly basic technical equipment developed for 5 different research projects in the discussed area of interactions of EM field and biological systems.

Cellular Radiofrequency Electromagnetic Field can be measured only by Nanotechnological Methods

Autoři: Havelka, D., Cifra, M., prof. Ing. Jan Vrba, CSc.,
Publikace: ISMOT Proceedings 2011. Praha: FEL ČVUT, 2011. pp. 307-310. ISBN 978-80-01-04887-0.
Rok: 2011

Pracoviště: Katedra elektromagnetického pole
Anotace:
The eukaryotic cell is a basic unit of plants, fungi and animals and it is also a likely source of electromagnetic field whose function we would like to examine in the future. Eukaryotic cells contain various organelles and structures. It is expected that the electromagnetic activity originates mainly in cytoskeleton that is a structure that protects and organizes the cell, enables a motion of the cell and is necessary for cell division. This structure is composed of three types of filaments. Microtubules, which are one of them,fulfil all conditions for generation of cellular electromagnetic field. We approximate electrical properties of basic structure of a microtubule (tubulin heterodimer) as elementary electric dipole and then we calculate electromagnetic field around them. In this paper, we present results from calculations of power and electric intensity around two models of microtubule network

Comparison of Several Horn Apertures for Impedance Matching of Microwave Applicators

Autoři: Vydra, T., prof. Ing. Jan Vrba, CSc.,
Publikace: ISMOT Proceedings 2011. Praha: FEL ČVUT, 2011. pp. 371-374. ISBN 978-80-01-04887-0.
Rok: 2011

Pracoviště: Katedra elektromagnetického pole
Anotace:
Industrial applications of electromagnetic field often require usage of resonator-type applicator (other types of applicators would by inefficient). This type of applicator provides very homogeneous characteristics of SAR (specific absorbed energy). But if not properly optimized or if not frequency stable source is used it can result in high return losses thus lowering the efficiency of the process. In this work we aim to inspect several types of horn apertures with emphasis on good optimization for the given working frequency and on the return losses in case of frequency instability. We suggest a suitable conjunction of excitation waveguide and resonator-type applicator at frequency 2.45 GHz and we present its characteristics.

Complex Permittivity Measurement as Imaging Method

Autoři: Vorlíček, J., Ing. Ladislav Oppl, Ph.D., prof. Ing. Jan Vrba, CSc.,
Publikace: ISMOT Proceedings 2011. Praha: FEL ČVUT, 2011. pp. 521-525. ISBN 978-80-01-04887-0.
Rok: 2011

Pracoviště: Katedra elektromagnetického pole
Anotace:
Complex permittivity measurements are important in microwave engineering, material processing, as well as biomedical applications. Probe for measuring the complex permittivity of biological tissues has been adapted from a standard RF connector for coaxial cable, called N-type connector. The original proposed range of application was fBW = 1 GHz. A typical measurement setup using the reflection method on an open-ended coaxial line consists of the network analyzer, the coaxial probe and software. Our measurements were done with the aid of Agilent 6052 network analyzer in the frequency range from 300 MHz to 3 GHz. First the calibration of the vector network analyzer is performed. Then the calibration using a reference material is done. Finally, the reflection coefficient of material under test is measured. The complex permittivity of material under test is evaluated by the MATLAB. The initial measurements on the inhomogeneous agar phantom were performed.

Effect of Dynamic Changes of Processed Material on Applicator Characteristics

Autoři: Vydra, T., prof. Ing. Jan Vrba, CSc.,
Publikace: ISMOT Proceedings 2011. Praha: FEL ČVUT, 2011. pp. 363-366. ISBN 978-80-01-04887-0.
Rok: 2011

Pracoviště: Katedra elektromagnetického pole
Anotace:
In this work we study how changes mentioned above influence impedance matching of a source of electromagnetic field. We, using numerical simulator of electromagnetic field, model simple applicator made of section of waveguide with horn aperture with load (i.e. tested sample for processing) inserted in front of the applicator (excitation is in form of coaxial antenna protruding to the cavity of the waveguide). Material properties are changed to various values (according to water loss conductivity of sample is reduced during the processing, relative permittivity remains more or less constant) and we inspect how applicator optimization is compromised and how relative absorbed energy changes (SAR (specific absorption rate) for optimized applicator and non-optimized are compared) due to these changes.

EM Field Based Microwave Technologies in Industry

Autoři: prof. Ing. Jan Vrba, CSc., Vydra, T., Pourová, M., Vrba jr., J., Vorlíček, J.
Publikace: ISMOT Proceedings 2011. Praha: FEL ČVUT, 2011. pp. 351-354. ISBN 978-80-01-04887-0.
Rok: 2011

Pracoviště: Katedra elektromagnetického pole
Anotace:
In this paper we describe our new results dealing with microwave industrial applicators used for drying of textile materials. We have designed and evaluated two different types of these applicators: open-resonator-type and waveguide-type one. We describe here basic models of the discussed applicators, results of numerical modeling and experimental evaluation as well. Prototype of microwave drying machine working at frequency 2.45 GHz is reported.

EM Field Based Microwave Technologies in Medicine

Autoři: prof. Ing. Jan Vrba, CSc., Ing. Ladislav Oppl, Ph.D., Vorlíček, J., Vrbová, B., Vrba, D., Vydra, T., Havelka, D.
Publikace: ISMOT Proceedings 2011. Praha: FEL ČVUT, 2011. pp. 319-323. ISBN 978-80-01-04887-0.
Rok: 2011

Pracoviště: Katedra elektromagnetického pole
Anotace:
Medical applications of microwaves (i.e. a possibility to use microwave energy and/or microwave technique and technology for therapeutical purposes) are a quite new and a very rapidly developing field. Microwave thermotherapy is being used in medicine for the cancer treatment and treatment of some other diseases since early eighties. In this contribution we would like to offer general overview of present activities in the Czech Republic, i.e. clinical applications and results, technical aspects of thermo therapeutic equipment and last but not least, prospective diagnostics based on microwave principals and technology and instrumentation.

High-frequency electric field and radiation characteristics of cellular microtubule network

Autoři: Havelka, D., Cifra, M., Kučera, O., Pokorný, J., prof. Ing. Jan Vrba, CSc.,
Publikace: Journal of Theoretical Biology. 2011,(286), 31-40. ISSN 0022-5193.
Rok: 2011

DOI: 10.1016/j.jtbi.2011.07.007
Odkaz: https://doi.org/10.1016/j.jtbi.2011.07.007
Pracoviště: Katedra elektromagnetického pole
Anotace:
In this paper, results from the calculation of intensity of electric field and of radiated electromagnetic power from the whole cellular microtubule network are presented.

Intracavitary Hyperthermia Applicator Research for Cancer Treatments

Autoři: Vrbová, B., prof. Ing. Jan Vrba, CSc.,
Publikace: ISMOT Proceedings 2011. Praha: FEL ČVUT, 2011. pp. 337-341. ISBN 978-80-01-04887-0.
Rok: 2011

Pracoviště: Katedra elektromagnetického pole
Anotace:
Main aim of this paper is to verify and thus support experimental results given in recently published paper: "Prospects for radiofrequency hyperthermia applicator research. I-Preoptimised prototypes of endocavitary applicators with matching interfaces for prostate hyperplasia and cancer treatments" via electromagnetic (EM) field simulations (in order to determine a 3D SAR distribution in the treated area). In the above mentioned paper we selected a helix radiating structures case only for our simulations. Scientific contribution of this paper is thus based on comparison of 3D SAR distribution obtained by EM simulations vs. that obtained by experimental evaluation. In this paper we will present 3D SAR simulations of "8mm OD helix structure" applicator working at 27.12 MHz, which is of novel design.

Measurement and Analysis of Microwave Processing of Biopolymers

Autoři: Vydra, T., Vorlíček, J., prof. Ing. Jan Vrba, CSc.,
Publikace: Proceedings of 21st International Conference Radioelektronika 2011. Brno: VUT v Brně, FEKT, Ústav radioelektroniky, 2011. pp. 297-300. ISBN 978-1-61284-322-3.
Rok: 2011

DOI: 10.1109/RADIOELEK.2011.5936398
Odkaz: https://doi.org/10.1109/RADIOELEK.2011.5936398
Pracoviště: Katedra elektromagnetického pole
Anotace:
Biopolymers can be effectively used in many contemporary applications. Modern means of processing biopolymers enable usage of them in new ways and situations which were previously dominated by conventional plastic materials. It is essential for further research and practical applications that we well know processes which are ongoing during the microwave processing. We present methodology specifically intended for examination and evaluation of effects of microwave processing of biopolymers in well defined electromagnetic field. We use microwave exposure system designed to meet all the requirements for visualization of the processing [1] and we use results given by the visualization (i.e. video recording and/or captured pictures) to analyze progression and changes in the exposed samples using Matlab [2] for image processing. In this paper we also present obtained results and propose future use of the system in industrial (and possibly medical) applications.

Microwave Applicators for Industrial Purposes

Autoři: prof. Ing. Jan Vrba, CSc., Stejskal, M., Vrba jr., J., Vydra, T., Pourová, M.
Publikace: PIERS 2011 Marrakesh Proceedings. Cambridge, MA: The Electromagnetics Academy, 2011. pp. 1825-1829. ISSN 1559-9450. ISBN 978-1-934142-16-5.
Rok: 2011

Pracoviště: Katedra elektromagnetického pole
Anotace:
In this paper, we describe our new results dealing with microwave industrial appli-cators used for drying of textile materials. We have designed and evaluated two di(R)erent types of these applicators: open-resonator-type and waveguide-type one. We describe here basic models of the discussed applicators, results of numerical modelling and experimental evaluation as well. Prototype of microwave drying machine working at frequency 2.45 GHz is reported.

Microwave Exposure Systems for Research of Biological Effects of EM Field

Autoři: prof. Ing. Jan Vrba, CSc., Víšek, L., Ing. Ladislav Oppl, Ph.D., Vrba, D., Vrbová, B., Havelka, D.
Publikace: ISMOT Proceedings 2011. Praha: FEL ČVUT, 2011. pp. 343-345. ISBN 978-80-01-04887-0.
Rok: 2011

Pracoviště: Katedra elektromagnetického pole
Anotace:
Research of interactions between EM field and biological systems is of growing interests elsewhere. Also here in Czech Republic there are several groups working in this field, often in international co-operations. We will describe here mainly basic technical equipment developed for 5 different research projects in the discussed area of interactions of EM field and biological systems.

Non-invasive Measurement of Complex Permittivity of Dielectric Substrates

Autoři: Vorlíček, J., Ing. Ladislav Oppl, Ph.D., prof. Ing. Jan Vrba, CSc.,
Publikace: ISMOT Proceedings 2011. Praha: FEL ČVUT, 2011. pp. 527-530. ISBN 978-80-01-04887-0.
Rok: 2011

Pracoviště: Katedra elektromagnetického pole
Anotace:
Complex permittivity measurements are important in microwave engineering, material processing, as well as biomedical applications. Recently, planar circuits, such as microstrip lines, coplanar waveguides, and strip lines have found their applications in complex permittivity measurements. Planar structures, which are lightweight, compact and low cost, have been successfully applied to the determination of substrate permittivity, material moisture etc. Planar circuit measurements are classified into resonant methods (with high accuracy and sensitivity) and non-resonant methods (broadband measurements). When choosing the measurement method, we have to take into account the non-destructive form of measurement. Therefore the most appropriate method is a modified resonance method.

Numerical Dosimetry of Whole-Body Exposure System

Autoři: Víšek, L., prof. Ing. Jan Vrba, CSc., Ing. Ladislav Oppl, Ph.D.,
Publikace: ISMOT Proceedings 2011. Praha: FEL ČVUT, 2011. pp. 347-350. ISBN 978-80-01-04887-0.
Rok: 2011

Pracoviště: Katedra elektromagnetického pole
Anotace:
The whole-body exposure system for unrestrained mice was designed in order to analyze the influence of electromagnetic field. The setup operating at 900MHz was designed with respect to induced uniform field, external radiation elimination, absorbed power determination, sufficient space for mice movement together witheven mice exposure and costs. The main aim of this paper is to assure that the dosimetry results reached by computer simulations can be used for determination of absorbed power in the unrestrained mouse. The whole-body exposure chamber with anatomical mouse model was simulated by two different numerical methods e.g. finite-difference-time-domain method (FDTD) and Finite Integration Technique (FIT) and its dosimetry results were compared by computed SAR values.

Parametric Study of Heating of Oil and Water Emulsions during Microwave Assisted Emulsion Separation

Autoři: prof. Ing. Jan Vrba, CSc., Jansen, R.H.
Publikace: ISMOT Proceedings 2011. Praha: FEL ČVUT, 2011. pp. 367-370. ISBN 978-80-01-04887-0.
Rok: 2011

Pracoviště: Katedra elektromagnetického pole
Anotace:
In this paper, the methodology and some results of an analysis of resistive and dielectric heating occurring inevitably during microwave (MW) processing of oil in water (O/W) and water in oil (W/O) emulsions, are described. A well proven commercial finite-element tool was used in order to perform transient coupled electric field - heat transfer simulations of emulsion samples. In these simulations, available temperature - dependent models of the two main emulsion components (water and oil) physical properties and process parameters of two different industrial MW processes were considered. The applied frequencies of the MW electromagnetic field are, dependent on the particular MW process, 915 MHz or 2450 MHz.

Přehled práce v oblasti buněčného elektromagnetického pole

Autoři: Havelka, D., Cifra, M., Vydra, T., prof. Ing. Jan Vrba, CSc.,
Publikace: Sborník 9. česko-slovenské konference. Ostrava: VŠB, 2011. pp. 214-217. ISBN 978-80-248-2475-8.
Rok: 2011

Pracoviště: Katedra elektromagnetického pole
Anotace:
Tento článek shrnuje práci provedenou naším týmem za několik posledních let. Zaměřujeme se především na základní výzkum týkající se elektromagnetického pole eukaryotických buněk. Naše práce navazuje na dlouholetý výzkum prováděný v této oblasti, jehož počátky se datují do šedesátých let minulého století [1-3]. V tomto článku naleznete výtah z několika publikací, které se zabývají výpočtem elektromagnetického pole jak v okolí samostatného mikrotubulu, tak i v okolí několika modelů mikrotubulární sítě. V závěru článku prezentujeme plánovaný experiment, který nám umožní experimentálně ověřit vlastní rezonanční frekvence mikrotubulů.

Prospective Applications of EM Fields in Medicine

Autoři: prof. Ing. Jan Vrba, CSc., Ing. Ladislav Oppl, Ph.D., Vrba, D., Vorlíček, J., Vrbová, B., Havelka, D.
Publikace: PIERS 2011 Marrakesh Proceedings. Cambridge, MA: The Electromagnetics Academy, 2011. p. 1816-1821. ISSN 1559-9450. ISBN 978-1-934142-16-5.
Rok: 2011

Pracoviště: Katedra elektromagnetického pole
Anotace:
Medical applications of microwaves (i.e., a possibility to use microwave energy and/or microwave technique and technology for therapeutical purposes) are a quite new and a very rapidly developing feld. Microwave thermotherapy is being used in medicine for the cancer treatment and treatment of some other diseases since early eighties. In this contribution we would like to offer general overview of present activities in the Czech Republic, i.e., clinical applications and results, technical aspects of thermo therapeutic equipment and last but not least, prospective diagnostics based on microwave principals ant technology and instrumentation.

Prospective Applications of Microwaves in Medicine

Autoři: Vorlíček, J., Vrbová, B., prof. Ing. Jan Vrba, CSc.,
Publikace: ADVANCES IN CANCER THERAPY. Rijeka: InTech, 2011. p. 507-532. ISBN 978-953-307-703-1.
Rok: 2011

Pracoviště: Katedra elektromagnetického pole
Anotace:
Research of interactions between Electromagnetic (EM) Field and biological systems is of growing interests elsewhere. In this area of research very important activity are studies of prospective medical applications of microwaves (i.e. a possibility to use microwave energy and/or microwave technique and technology for treatment purposes) are a quite new and a very rapidly developing field. Microwave thermotherapy is being used in medicine for the cancer treatment and for some other diseases since early eighties. Most common methods used for treatment of cancer are radiotherapy and chemotherapy. These therapeutic methods have many undesirable effects, such as usage of ionizing radiation. Another method used for treatment of cancer is hyperthermia.

Prospects for Radiofrequency Hyperthermia Applicator Research

Autoři: Franconi, C., prof. Ing. Jan Vrba, CSc., Micali, F., Pesce, F.
Publikace: International Journal of Hyperthermia. 2011, 27(2), 187-198. ISSN 0265-6736.
Rok: 2011

DOI: 10.3109/02656736.2010.521886
Odkaz: https://doi.org/10.3109/02656736.2010.521886
Pracoviště: Katedra elektromagnetického pole
Anotace:
This paper deals with a reserach of intracavitary applicators for microwave thermotherapy (e.g. cancer treatment or Benign Prostate Hyperplasia treatment). During this feasibility study sbove all combination of monopole and helix structure were studied and experimentaly evaluated.

Study of SAR Distribution by Using Two Layers of Microwave Stripline TEM Mode Applicators

Autoři: Vrbová, B., prof. Ing. Jan Vrba, CSc.,
Publikace: ISMOT Proceedings 2011. Praha: FEL ČVUT, 2011. pp. 325-333. ISBN 978-80-01-04887-0.
Rok: 2011

Pracoviště: Katedra elektromagnetického pole
Anotace:
In this contribution we deal with simulations of SAR distribution obtained by array of microwave stripline type TEM mode applicators of the same type working at frequency 434 MHz. In this study we describe the SAR distribution created in the treated area by two layers of these applicators radiating into an anatomical model of calf of human body. The main aim of this study is to compare SAR distribution for changing distance between these two layers of applicators. In each of both layers is the same number of applicators.

Superficial Hyperthermia: Clinical Study in the Treatment of Patients with Head and Neck Cancers

Autoři: Ing. Ladislav Oppl, Ph.D., Zapletal, R., prof. Ing. Jan Vrba, CSc., Kubeš, J.
Publikace: ISMOT Proceedings 2011. Praha: FEL ČVUT, 2011. pp. 311-314. ISBN 978-80-01-04887-0.
Rok: 2011

Pracoviště: Katedra elektromagnetického pole
Anotace:
In this paper is presented one of clinical studies as a result our longstanding cooperation on the field of microwave thermotherapy. Microwave thermotherapy - hyperthermia in combination with other treatment methods (especially with teleradiotherapy) is currently very important and effective method for cancer treatment. This treatment method is used in the Institute of Radiation Oncology at Bulovka University Hospital in Prague since early eighties of last century. Technical equipment for superficial microwave hyperthermia used for cancer treatment at this clinical working place is described as well.

What is More Important for Radiated Power from Cells - Size or Geometry?

Autoři: Havelka, D., Cifra, M., prof. Ing. Jan Vrba, CSc.,
Publikace: Journal of Physics: Conference Series. 2011,(329), 012014/1-012014/9. ISSN 1742-6588.
Rok: 2011

DOI: 10.1088/1742-6596/329/1/012014
Odkaz: https://doi.org/10.1088/1742-6596/329/1/012014
Pracoviště: Katedra elektromagnetického pole
Anotace:
Microtubule network is a very dynamic structure which is composed of highly polar molecules - tubulin heterodimers. Microtubules have their eigenmode vibrations in frequency range from kHz to GHz. We approximated electrical properties of tubulin heterodimer as an elementary electric dipole and described the longitudinal mechanical oscillation of one microtubule by spatial modulation function. Mechanical oscillations of tubulin heterodimers were approximated as a chain of rigid particles and described by the spatial modulation function. We also created asymmetrical model of microtubule network of dividing cell and symmetrical model of microtubule network of non-dividing cell. The field around oscillating microtubule was calculated as a vector sum of contributions from all elementary electric dipoles. Finally, we performed calculations with several cell sizes and numbers of microtubules in models and performed comparative analysis.

Broadband Complex Permittivity Determination for Biomedical Applications

Autoři: Zajíček, R., prof. Ing. Jan Vrba, CSc.,
Publikace: Advanced Microwave Circuits and Systems. Vukovar: In-Teh, 2010. p. 365-385. ISBN 978-953-307-087-2.
Rok: 2010

Pracoviště: Katedra elektromagnetického pole
Anotace:
The chapter deals with an electrical description of biological tissues, analysis of the reflection coefficient measurement method, feasibility study of different measurement probes, development of model for numerical modeling and simulations and experimental measurement of various biological substances for applications in the basic research on biological effects of electromagnetic fields and for medical diagnostics and imaging. A non-destructive and non-invasive method based on the reflection coefficient measurement is used. Relation between the reflection coefficient and complex permittivity is derived using the Deschamps? theorem. Two types of coaxial probes are under investigation and feasibility study of waveguide probes is presented. Vector measurements of the reflection coefficient are performed in the frequency range from 300 kHz to 3 GHz. Numerical modeling is compared with measurement. Measurement uncertainty is evaluated.

Comparison of Constant and Temperature Dependent Blood Perfusion

Autoři: Dřížďal, T., Togni, P., Víšek, L., prof. Ing. Jan Vrba, CSc.,
Publikace: Radioengineering. 2010, 19(2), 281-289. ISSN 1210-2512.
Rok: 2010

Pracoviště: Katedra elektromagnetického pole
Anotace:
In this paper a constant and a temperature dependent blood perfusion are being studied and comparison of these two interesting cases is given. It has a big impact on a final temperature distribution in case of cancer tretament by microwave hyperthermia.

Comparison of Microwave Waveguide Applicators for Thermotherapy

Autoři: Vorlíček, J., Borovka, J., prof. Ing. Jan Vrba, CSc.,
Publikace: Progress in Electromagnetics Research Symposium (PIERS 2010 Xi'an). Cambridge, MA: The Electromagnetics Academy, 2010. pp. 579-583. ISSN 1559-9450. ISBN 978-1-934142-12-7.
Rok: 2010

Pracoviště: Katedra elektromagnetického pole
Anotace:
The purpose of this paper is to compare the three most used microwave thermo therapeutic applicators in hyperthermia oncology treatment. In this case we have been focused on the applicator's radiation pattern form the aperture and the depth of effective penetration of biological tissue. Applicators used in this survey are: TEM wave horn applicator, Lucite horn applicator and TE10 horn applicator. All three of them have the same size of aperture which makes them easy to compare. Simulations are performed in simulator of electromagnetic field SEMCAD BERNINA 13.4. Effective size of the aperture is determined using the script which we developed and the simulation of the depth of effective penetration in SEMCAD BERNINA 13.4.

Complex permittivity measurement of substrates using ring resonator

Autoři: Vorlíček, J., doc. Ing. Jan Rusz, Ph.D., Ing. Ladislav Oppl, Ph.D., prof. Ing. Jan Vrba, CSc.,
Publikace: Technical Computing Bratislava 2010. Bratislava: RT systems, s.r.o, 2010. pp. 1-6. 18th Annual Conference Proceedings. ISBN 978-80-970519-0-7.
Rok: 2010

Pracoviště: Katedra elektromagnetického pole, Katedra teorie obvodů
Anotace:
This paper deals with a complex permittivity measurement of dielectric substrates for planar circuits using ring resonator. This method is based on measurement of transmission and reflection coefficients of a transmission-type ring resonator with capacity coupling. Dielectric constant and the dissipation factor can be measured at wide frequency band by adjusting base resonant frequency of a ring resonator. Required parameters could be simply calculated according to information in this paper.

Evaluation of a Patch Antenna Applicator for Time Reversal Hyperthermia

Autoři: Dobšíček Trefná, H., prof. Ing. Jan Vrba, CSc., Persson, M.
Publikace: International Journal of Hyperthermia. 2010, 26(2), 185-197. ISSN 0265-6736.
Rok: 2010

DOI: 10.3109/02656730903436434
Odkaz: https://doi.org/10.3109/02656730903436434
Pracoviště: Katedra elektromagnetického pole
Anotace:
Analysis and evaluation of a new antenna array system for microwave hyperthermia is being described in this paper.This antenna array was evaluated by the focusing method based on the time-reversal principle.Power absorption distributions in a cylindrical homogeneous and inhomogeneous phantom were calculated for the frequency range 500-900 MHz. Two set-ups with 12 and 16 antennas were analysed by comparing changes in focusing areas enclosed by the 50%, 75% and 90% iso-SAR contours. The sharpest focusing area in the centre of the phantom, 151mm2 (920mm) (90% iso-SAR), was obtained by using 16 antennas at frequency 900 MHz. The largest focusing area of 280mm2 (1324mm) (90% iso-SAR) was obtained by using 16 antennas at 500 MHz. The conducted study confirms the feasibility of the time-reversal-based focusing methods for microwave hyperthermia. The proposed system shows promise and is suitable for further development in the treatment of head and neck tumours, and extremities applicatio

Matrix Composition of Microwave Stripline Applicators for Local Thermotherapy

Autoři: Vrbová, B., prof. Ing. Jan Vrba, CSc.,
Publikace: Proceedings of 15th Conference on Microwave Techniques COMITE 2010. Brno: VUT v Brně, FEKT, Ústav radioelektroniky, 2010. pp. 99-101. ISBN 978-1-4244-6351-0.
Rok: 2010

Pracoviště: Katedra elektromagnetického pole
Anotace:
This article describes the design and evaluation of microwave stripline applicator for treatment of malignant tumors located under the surface of biological tissue. This tissue is in our simulations mimicked by homogeneous agar phantom with similar characteristics as the biological tissue. Further this paper presents results from measurement of impedance matching and simulations of SAR distribution on planar agar phantom by using two same applicators and SAR distribution in cylindrical agar phantom by using composition of four applicators of the same type.

Measurement of Complex Permittivity of Biological Tissues

Autoři: Vorlíček, J., Ing. Ladislav Oppl, Ph.D., prof. Ing. Jan Vrba, CSc.,
Publikace: Proceedings of PIERS 2010 in Cambridge. Cambridge, MA: The Electromagnetics Academy, 2010. pp. 599-601. ISSN 1559-9450. ISBN 978-1-934142-14-1.
Rok: 2010

Pracoviště: Katedra elektromagnetického pole
Anotace:
This paper describes and evaluates a method for determining complex permittivity, and presents results of permittivity measurement of agar phantom of biological tissue. A nondestructive and non-invasive method based on reflection coefficient measurement of an open-ended coaxial line attaching the material under test is used. Vector measurement of the reflection coefficient on the interface between probes and measured samples is performed with the aid of network analyzer in the frequency range from 300 kHz to 3 GHz. The results indicate that using the coaxial probe with dimensions of N connector is suitable in the frequency range approximately from 30 MHz to 1 GHz.

Microwave Applicator for Hyperthermia Treatment on in Vivo Melanoma Model

Autoři: Togni, P., prof. Ing. Jan Vrba, CSc., Vannucci, L.
Publikace: Medical and Biological Engineering and Computing. 2010, 48(3), 285-292. ISSN 0140-0118.
Rok: 2010

DOI: 10.1007/s11517-009-0563-8
Odkaz: https://doi.org/10.1007/s11517-009-0563-8
Pracoviště: Katedra elektromagnetického pole
Anotace:
This work evaluates a planar microwave applicator for in vivo superficial hyperthermia treatments on small tumors in the mouse mimicking treatments for human neoplasms. The design of the applicator, was challenged by the small dimensions of the tumors and unwanted diffusion of heating in the tumor-bearing animals. The study was firstly performed by simulations of SAR distribution inside a homogeneous phantom, considering an integrated water bolus. Further tests were performed on homogeneous agar phantom to simulate the temperature distribution in the biological tissue and to assess the possible modality and schedule of hyperthermia delivery. The in vivo experiments showed the evidence of microwave-induced heating and damage of the melanoma tissue in a range of penetration coherent both with simulations and phantom studies. This approach appears perspective for designing limited microwave-delivery applicators for treatments of human superficial tumors and pre-tumoral les

Microwave Methods for Evaluation of Biological Effects of EM Fields

Autoři: Víšek, L., prof. Ing. Jan Vrba, CSc.,
Publikace: Workshop 2010. Praha: České vysoké učení technické v Praze, 2010. pp. 142-143. CTU Reports. ISBN 978-80-01-04513-8.
Rok: 2010

Pracoviště: Katedra elektromagnetického pole
Anotace:
The goal of this paper is to design, to simulate and to verify the whole-body exposure setup for unrestrained small animals which operates in 900MHz and offer a new possibility to measure lossy power in the living organism. The anatomical based model of mouse was developed by aid of segmentation tool. The basic properties such as electromagnetic field distribution and impedance matching of the designed chamber were optimized and verified by the aid of a 3D electromagnetic field simulator. By aid of anatomical model in simulations the dosimetry results were obtained.

Ovlivnění léčebného efektu radiofrekvenční ablace aplikací vhodných nanostruktur

Autoři: Nováková, M., prof. Ing. Jan Vrba, CSc.,
Publikace: Sborník abstraktů přednášek - Diagnostika, léčba a prevence závažných civilizačních onemocnění. Plzeň: Euroverlag, 2010, pp. 1. ISBN 978-80-7177-034-3.
Rok: 2010

Pracoviště: Katedra elektromagnetického pole
Anotace:
Radiofrekvenční ablace je minimálně invazivní metodou, vhodnou k léčbě některých typů primárních i sekundárních nádorů. Principem metody je dodání proudu do cílového ložiska nádoru pomocí speciálních elektrod zavedených přes kůži pacienta pod CT (výpočetní tomografie), MR (magnetická rezonance) nebo ultrazvukovou kontrolou a při místním znecitlivění tkání až do léčeného nádoru. Při průchodu proudu dochází k pohybu iontů a molekul vody v nádorových tkáních. Výsledkem je zvýšení vnitřní energie těchto částic a její přeměna na teplo. Buňky jsou tak zahřáté na teplotu 50 °C a vyšší, čímž dochází k jejich nevratnému poškození a následně k jejich smrti.

Stripline Microwave Applicator with Impedance Transformer for Local Thermotherapy

Autoři: Vorlíček, J., prof. Ing. Jan Vrba, CSc.,
Publikace: Proceedings of 15th Conference on Microwave Techniques COMITE 2010. Brno: VUT v Brně, FEKT, Ústav radioelektroniky, 2010. pp. 81-83. ISBN 978-1-4244-6351-0.
Rok: 2010

DOI: 10.1109/COMITE.2010.5481275
Odkaz: https://doi.org/10.1109/COMITE.2010.5481275
Pracoviště: Katedra elektromagnetického pole
Anotace:
This article deals with the design, construction and testing of microwave TEM wave applicator with impedance transformer. Applicator is designed to work on the frequency f = 434MH and its aperture has a size of 100mm x 75mm. Applicator is made of copper and filled with distilled water. Design simulation and the simulations of SAR distribution are created in program SEMCAD 13.4 BERNINA. Final evaluation of construction solution is established on SIXPORT for S11 coefficient and evaluation of SAR distribution is done by infrared camera FLIR P25.

The Whole-Body Exposure Chamber for Unrestrained Mice

Autoři: Víšek, L., prof. Ing. Jan Vrba, CSc.,
Publikace: 6th International Workshop on Biological Effects of Electromagnetic Fields. Istanbul: Bogazici University, 2010.
Rok: 2010

Pracoviště: Katedra elektromagnetického pole
Anotace:
The main aim of this paper is to assure if the dosimetry results reached by computer simulations can be used for exact determination of absorbed power in the biological tissue. The whole-body exposure chamber with anatomical mouse model was simulated by two different numerical methods e.g. finite-difference-time-domain method (FDTD) and Finite Integration Technique (FIT) and its dosimetry results were compared and verified by computed SAR values.

Time -reversal Focusing in Microwave Hyperthermia for Deep-seated Tumors

Autoři: Dobšíček Trefná, H., prof. Ing. Jan Vrba, CSc., Persson, M.
Publikace: Physics in Medicine and Biology. 2010, 55(8), 2167-2185. ISSN 0031-9155.
Rok: 2010

DOI: 10.1088/0031-9155/55/8/004
Odkaz: https://doi.org/10.1088/0031-9155/55/8/004
Pracoviště: Katedra elektromagnetického pole
Anotace:
In this paper a principal of Time -reversal Focusing in Microwave Hyperthermia for Deep-seated Tumors is being described and explained. It has a big impact on a final temperature distribution in case of cancer treatment by microwave hyperthermia.

Waveguide-based Applicators for Local Microwave Thermotherapy: Feasibility Study of Matrix Array Treatment

Autoři: Vrbová, B., prof. Ing. Jan Vrba, CSc.,
Publikace: Progress in Electromagnetics Research Symposium (PIERS 2010 Xi'an). Cambridge, MA: The Electromagnetics Academy, 2010. pp. 1369-1372. ISSN 1559-9450. ISBN 978-1-934142-12-7.
Rok: 2010

Pracoviště: Katedra elektromagnetického pole
Anotace:
In this article we deal with feasibility study of microwave cancer treatment by array of waveguide based applicators. Paper brings description of design, realization and evaluation of two, three or four microwave waveguide-based applicators set-up intended to treat malignant tumors, which are located on the surface of biological tissue. This tissue is in our work simu- lated by homogeneous agar phantom, which has similar dielectric and thermal characteristics as the biological tissue. In this article we use a composition of several applicators to enlarge the irradiated surface and to observe shapes of SAR distribution on a planar and cylindrical agar phantom.

Design of the Time-Reversal Hyperthermia System

Autoři: Dobšíček Trefná, H., Togni, P., prof. Ing. Jan Vrba, CSc., Persson, M.
Publikace: EuCAP 2009 - 3rd European Conference on Antennas and Propagation. New York: IEEE, 2009. pp. 1506-1509. ISBN 978-1-4244-4753-4.
Rok: 2009

Pracoviště: Katedra elektromagnetického pole
Anotace:
In this contribution, the prototype of the new hyperthermia system based on time-reversal focusing method is presented. The system is designed for a broad frequency range, between 300 MHz to 1 GHz. The optimal frequency for a specific treatment is dependent on the tumor positioning and size. The second advantage of the present system is that it can be used for single frequency operation as well as for gaussian pulses. The main purpose of the prototype is to validate the feasibility of the time reversal planning method by experiments on phantoms of biological tissues and animals. After replacement of power amplifiers by more powerful ones, the system will be used for the treatment of the Head and Neck region and extremities.

Measurement and Computer Simulation of Electromagnetic Oscillations of Living Cells

Autoři: Cifra, M., Pokorný, J., prof. Ing. Jan Vrba, CSc.,
Publikace: Workshop 09 CTU REPORTS. Praha: České vysoké učení technické v Praze, 2009. pp. 338-339. ISBN 978-80-01-04286-1.
Rok: 2009

Pracoviště: Katedra elektromagnetického pole
Anotace:
Frohlich postulated coherent polar oscillations as a fundamental biophysical property of biological systems. Recently, Pelling et al. (2004, 2005) detected mechanical vibrations of yeast cell membrane with atomic force microscope (AFM) and analyzed by Fourier analysis in the frequency range 0.5-2 kHz with amplitudes of the order of 1 nm. This article describes the measurement of electric activity of yeast cells in the acoustic frequency range and of mechanical vibrations of cell membrane. Spectrum analyzer and electrically and > electromagnetically screened box with point sensor and amplifiers fed by batteries were used for measurement of synchronized and non synchronized tubulin mutants of yeast cells. We show that the electric activity of synchronized cells in the M phase is greater that of non synchronized cells. That corresponds to the findings of Pohl et al. (1981). Obtained results of measurement of cell electric activity are in good agreement with AFM findings.

Microwave Drying Machine for Textile Materials

Autoři: prof. Ing. Jan Vrba, CSc., Stejskal, M., Pourová, M.
Publikace: European Microwave Week 2009 - Conference Proceedings. London: Horizon House Publications, 2009. p. 1121-1124. ISBN 978-1-4244-4748-0.
Rok: 2009

Pracoviště: Katedra elektromagnetického pole
Anotace:
In this paper we describe our new results dealing with microwave industrial applicators used for drying of textile materials. We have designed and evaluated two different types of these applicators: open-resonator-type and waveguide-type one. We describe here basic models of the discussed applicators, results of numerical modeling and experimental evaluation as well. Prototype of microwave drying machine working at frequency 2.45 GHz is reported.

Microwave Medical Imaging and Diagnostics

Autoři: prof. Ing. Jan Vrba, CSc., Ing. Ladislav Oppl, Ph.D., Trefná, H., Žák, O., Pourová, M., Dřížďal, T., Zajíček, R.
Publikace: PIERS 2009 Beijing - Progress In Electromagnetics Research Symposium - Draft Abstracts. Cambridge, MA: The Electromagnetics Academy, 2009. p. 1461-1465. ISSN 1559-9450. ISBN 978-1-934142-08-0.
Rok: 2009

Pracoviště: Katedra elektromagnetického pole
Anotace:
Future trends in medical applications of microwave technique and technology can be seen in development of new diagnostic and imaging methods based on high frequency EM field. A significant importance for the future can be identified for the following methods: Mi- crowave tomography, Microwave radiometry, Measurement of complex permittivity, Imaging in the Terahertz waves band and Microwave diagnostic radars.

Planar Applicators for Hypertermia Treatments

Autoři: Togni, P., prof. Ing. Jan Vrba, CSc., Vannucci, L.
Publikace: Workshop 09 CTU REPORTS. Praha: České vysoké učení technické v Praze, 2009. pp. 340-341. ISBN 978-80-01-04286-1.
Rok: 2009

Pracoviště: Katedra elektromagnetického pole
Anotace:
The aim of this project was to treat mice with melanoma tumors. In order to fulfill these requirements, a planar microwave applicator was developed.The applicator was composed by a cavity with a circular radiating slot. The dimensions of the applicator were chosen to have resonance frequency at 2450 MHz. To reduced the risk of skin overheating the applicator was designed with an integrated water bolus. The applicator optimization and preliminary evaluation was made using computer simulators. To perform the in-vivo experiments a microwave system was developed too. The preliminary tests were performed on homogeneous flat phantom before to move to the in-vivo model. The attention was especially paid on the enhancement of the temperature in the depth, to evaluate the eventuality of body temperature enhancement during the treatments. Several in-vivo experiments have shown how this applicator was suitable for in-vivo studies with clinical perspectives on human patients.

Prospective Applications of Microwaves in Medicine

Autoři: prof. Ing. Jan Vrba, CSc.,
Publikace: 12th International Symposium on Microwave and Optical Technology. New Delhi: University of Delhi, 2009. p. 1357-1360.
Rok: 2009

Pracoviště: Katedra elektromagnetického pole
Anotace:
Medical applications of microwaves (i.e. a possibility to use microwave energy and/or microwave technique and technology for therapeutical purposes) are a quite new and a very rapidly developing field. Microwave thermotherapy is being used in medicine for the cancer treatment and treatment of some other diseases since early eighties. In this contribution we would like to offer general overview of present activities in the Czech Republic, i.e. clinical applications and results, technical aspects of thermo therapeutic equipment and last but not least, prospective diagnostics based on microwave principals ant technology and instrumentation.

Slot-Line Applicator for Microwave Hyperthermia

Autoři: Togni, P., Dřížďal, T., prof. Ing. Jan Vrba, CSc., Vannucci, L.
Publikace: Journal of Microwave Power and Electromagnetic Energy. 2009, 2009(43-2), 43-2-24-43-2-30. ISSN 0832-7823.
Rok: 2009

Pracoviště: Katedra elektromagnetického pole
Anotace:
Electromagnetic field interaction with biological tissues and their applications in cancer treatment research has become of growing interest of many research centers all around the world. This paper describes the possibility of using a slot-line type applicator for microwave hyperthermia treatment. The purpose of this article is to present that this type of applicator is particularly suitable for the treatment of superficial tumours in depths 2-3 cm below the body surface. To support this hypothesis we use 3D electromagnetic field simulator for prediction of specific absorption rate (SAR), and the consequent temperature distribution in the area under treatment. The results of the simulations are supported by experimental temperature measurements made with the help of an infrared thermo-camera on a homogeneous agar phantom.

Technical Basis for Research of Biological Effects of EM Field

Autoři: prof. Ing. Jan Vrba, CSc., Togni, P., Víšek, L., Ing. Ladislav Oppl, Ph.D., Vrba, D., Vannucci, L.
Publikace: 12th International Symposium on Microwave and Optical Technology. New Delhi: University of Delhi, 2009. p. 1373-1376.
Rok: 2009

Pracoviště: Katedra elektromagnetického pole
Anotace:
Research of interactions between EM Field and biological systems is of growing interests elsewhere. Also here in Czech Republic there are several groups working in this field, often in international co-operations. We will describe here mainly basic technical equipment developed for 5 different research projects in the discussed area of interactions of EM field and biological systems.

Technical Equipment for Research of EM Field and Biological Systems Interactions

Autoři: prof. Ing. Jan Vrba, CSc., Vannucci, L., Togni, P., Víšek, L.
Publikace: PIERS 2009 Beijing - Progress In Electromagnetics Research Symposium - Draft Abstracts. Cambridge, MA: The Electromagnetics Academy, 2009. pp. 1456-1460. ISSN 1559-9450. ISBN 978-1-934142-08-0.
Rok: 2009

Pracoviště: Katedra elektromagnetického pole
Anotace:
Research of interactions between EM Field and biological systems is of growing interests elsewhere. Also here in Czech Republic there are several groups working in this field, often in international co-operations. We will describe here mainly basic technical equipment developed for 5 di(R)erent research projects in the discussed area of interactions of EM Field and biological systems.

TR-hyperthermia System Prototype: First Phantom Experiments

Autoři: Dobšíček Trefná, D.T.H., Togni, P., prof. Ing. Jan Vrba, CSc., Persson, P.M.
Publikace: 25th Annual Meeting of the European Society for Hyperthermic Oncology - Abstract Book. Verona: Ospedale Borgo Trento, U.O.Radioterapie, 2009. p. 32.
Rok: 2009

Pracoviště: Katedra elektromagnetického pole
Anotace:
A wideband system for time-reversal hyperthermia was evaluated. The system was composed by 12 channels and an antenna system made by circular arranged elements which could be placed in different configurations. The experimental results for the real system includes temperature distribution achieved in dielectrical phantoms of muscles tissue. The obtained results confirm the feasibility of the time-reversal based focusing methods in sense of improved energy distribution in the phantom.

Water Bolus Influence on Temperature Distribution of Applicator for Small Melanoma Tumors

Autoři: Togni, P., prof. Ing. Jan Vrba, CSc., Vannucci, L.
Publikace: European Microwave Week 2009 - Conference Proceedings. London: Horizon House Publications, 2009. pp. 874-877. ISBN 978-1-4244-4748-0.
Rok: 2009

Pracoviště: Katedra elektromagnetického pole
Anotace:
In this paper influence of the water bolus temperature on the thermal distribution inside an homogeneous muscles phantom are analyzed. Temperature simulations were used for the analysis considering two different thermal models. The results show dependence of the temperature peak deepness which position reduces increasing the bolus temperature. These results can be used as a preliminary guideline water bolus temperature choise during in-vivo experiments.

Applicator for In-vivo Experiments on Mice with Melanoma Tumour

Autoři: Togni, P., prof. Ing. Jan Vrba, CSc., Vannucci, L.
Publikace: Proceedings of the 14th Conference on Microwave Techniques COMITE 2008. Praha: Československá sekce IEEE, 2008. pp. 129-132. ISBN 978-1-4244-2137-4.
Rok: 2008

Pracoviště: Katedra elektromagnetického pole
Anotace:
This paper describes a MW applicator designed to treat mice with small melanoma tumours. The applicator is composed by a planar dielectric structure metallized on both sides. The two metallizations are shorted all around the applicator in order to create a cavity resonator at the frequency 2450 MHz. On one metallization is obtained a slot-line ring aperture with the function to radiate the energy to the biological tissue. An EM field simulator was used to optimize the dimensions of the applicator in order to obtain the most suitable power absorption distribution inside the biological tissue. The simulator was also used to predict the SAR distribution inside an agar phantom with EM characteristics similar to muscles tissue. The results of simulations are supported by temperature measurements made on agar phantom. These results have shown the possibility to use this applicator for in-vivo experiment on mice with small melanoma tumors.

Broadband Measurement of Complex Permittivity Using Reflection Method and Coaxial Probes

Autoři: Zajíček, R., Ing. Ladislav Oppl, Ph.D., prof. Ing. Jan Vrba, CSc.,
Publikace: Radioengineering. 2008, 17(1), 14-19. ISSN 1210-2512.
Rok: 2008

Pracoviště: Katedra elektromagnetického pole
Anotace:
Paper describes and evaluates a method for determining complex permittivity, and presents results of dielectric measurements of some substances. Complex permittivity of a phantom of biological muscle tissue, of some industrial chemicals and dielectric is found out. A suitable way to make a dielectric measurement that is nondestructive and noninvasive is to use a reflection method on an open ended coaxial line. Two coaxial probes are under investigation. Vector measurement of the reflection coefficient on the interface between probes and measured samples is performed with the aid of network analyzer in frequency range from 300 kHz to 3 GHz. Numerical modeling (FDTD) is compared with real measurement and a comparison is presented. Results indicate that the reflection method is suitable for the determination of dielectric parameters: using the N-type coaxial probe is method applicable in frequency range app. from 30 MHz to 1 GHz and using SMA-type probe in range app. from 30 MHz to 3 GHz.

Design of an Exposure Chamber for Biological Experiments

Autoři: Víšek, L., prof. Ing. Jan Vrba, CSc., Ing. Ladislav Oppl, Ph.D.,
Publikace: Proceedings of PIERS 2008 in Cambridge. Cambridge, MA: The Electromagnetics Academy, 2008. pp. 771-774. ISSN 1559-9450. ISBN 978-1-934142-06-6.
Rok: 2008

Pracoviště: Katedra elektromagnetického pole
Anotace:
The aim of this paper is to design and to simulate an exposure chamber which offer a new possibility how to measure lossy power in biological tissue. The basic properties such as electromagnetic field distribution and impedance matching of our designed chamber were optimized and verified by the aid of a 3D electromagnetic field simulator. As a result of our effort a cylinder waveguide chamber with a working frequency 900MHz has been designed. This chamber offer a new way of dosimetry.

Experiences with Superficial Hyperthermia in the Treatment of Patients with Head and Neck Cancers

Autoři: Ing. Ladislav Oppl, Ph.D., Zapletal, J., prof. Ing. Jan Vrba, CSc., Kvěch, J., Kubeš, J., Pála, M.
Publikace: Proceedings of the 14th Conference on Microwave Techniques COMITE 2008. Praha: Československá sekce IEEE, 2008. pp. 146-150. ISBN 978-1-4244-2137-4.
Rok: 2008

Pracoviště: Katedra elektromagnetického pole
Anotace:
In this paper are presented experiences with combination of teleradiotherapy and superficial hyperthermia in the treatment of patients with head and neck cancers, especially in cases with superficial tumors or lymph node metastases, in the Institute of Radiation Oncology in Prague. Microwave thermotherapy - hyperthermia in combination with other treatment methods (mainly with teleradiotherapy) is currently very effective and important method for cancer treatment. Technical equipment for before-mentioned therapeutic method in this clinical working place is described as well. The treatment results are part of this paper as well.

Exposure System for Verification of Effects of Electromagnetic Field

Autoři: Víšek, L., prof. Ing. Jan Vrba, CSc., Ing. Ladislav Oppl, Ph.D.,
Publikace: Proceedings of the 14th Conference on Microwave Techniques COMITE 2008. Praha: Československá sekce IEEE, 2008. pp. 119-122. ISBN 978-1-4244-2137-4.
Rok: 2008

Pracoviště: Katedra elektromagnetického pole
Anotace:
The main aim of this work is to design and to simulate an exposure chamber which can simulate mobile phone emission patterns in order to analyze the influence of electromagnetic field on small animals. During our previous research we found the most suitable type of an exposure chamber for this purpose. The basic properties such as electromagnetic field distribution and impedance matching of our designed chamber were optimized and verified by the aid of a 3D electromagnetic field simulator. As a result of our effort a cylinder waveguide chamber with a working frequency 900MHz has been designed.

Feasibility Study of Superficial Hyperthermia Treatment Planning Using COMSOL Multiphysics

Autoři: Dřížďal, T., Vrba, M., Cifra, M., Togni, P., prof. Ing. Jan Vrba, CSc.,
Publikace: Proceedings of the 14th Conference on Microwave Techniques COMITE 2008. Praha: Československá sekce IEEE, 2008. pp. 155-158. ISBN 978-1-4244-2137-4.
Rok: 2008

Pracoviště: Katedra elektromagnetického pole
Anotace:
Microwave hyperthermia is a method of cancer treatment utilized different response of healthy and tumour tissue on elevated temperatures in interval of 40 - 44 °C. The goal of this paper is to introduce the possibility of treatment planning for superficial hyperthermia using COMSOL Multiphysics. The real model of the patient with recurrent breast cancer was developed. The waveguide horn applicator with aperture of 10 x 10 cm was used for the planning.

Future Trends in Medical Applications of Microwaves: Microwave Imaging and Diagnostics

Autoři: prof. Ing. Jan Vrba, CSc.,
Publikace: 18th International Travelling Summer School on Microwave and Lightwaves - Proceedings. Brno: VUT v Brně, FEKT, Ústav radioelektroniky, 2008. pp. 360-363.
Rok: 2008

Pracoviště: Katedra elektromagnetického pole
Anotace:
Paper deals with a very prospective field of research - with future trends in medical applications of microwaves, especialy about microwave imaging and diagnostics. It mentions the basic possibilities like imaging based on measurements of complex permittivity, microwave radiometry and microwave tomography.

Measurement of Dielectric Properties of Moisture Textile

Autoři: Pourová, M., Zajíček, R., Ing. Ladislav Oppl, Ph.D., prof. Ing. Jan Vrba, CSc.,
Publikace: Proceedings of the 14th Conference on Microwave Techniques COMITE 2008. Praha: Československá sekce IEEE, 2008. pp. 111-114. ISBN 978-1-4244-2137-4.
Rok: 2008

Pracoviště: Katedra elektromagnetického pole
Anotace:
The measurement of dielectric parameters of wet textile materials is very important for the design of microwave drying and heating applicators in textile industry. In this contribution there are presented results of two measurement systems - Six-port measurement system and Agilent Impedance/material analyzer. Dielectric properties generally depend on the frequency of applied electromagnetic field, moisture content, temperature and density of materials. However, the amount of water in the drying materials is mostly a dominant factor.

Medical Diagnostics Using Reflection Method and Waveguide Probes - Feasibility Study

Autoři: Zajíček, R., Smejkal, T., Ing. Ladislav Oppl, Ph.D., prof. Ing. Jan Vrba, CSc.,
Publikace: PIERS - Progress In Electromagnetics Research Symposium - Draft Proceedings. Cambridge, MA: The Electromagnetics Academy, 2008. p. 745-749. ISSN 1559-9450. ISBN 978-1-934142-06-6.
Rok: 2008

Pracoviště: Katedra elektromagnetického pole
Anotace:
Paper deals with complex permittivity measurement of biological tissues. Application of a waveguide probe for this measurement is shown. A nondestructive and noninvasive method based on reflection coefficient measurement - probe is attaching the material under test, is used. New types of the probes are under investigation - the section of waveguide with H cross-section, the section of waveguide with the rectangular cross-section and with shorted walls, the section of waveguide with inserted dielectric wedge and finally the section of waveguide filled with liquid dielectric. Properties of these prototypes are studied in frequency range from 300 kHz to 3 GHz. FDTD method is utilized for the numerical modeling and simulation of the reflection coefficient. Results indicate that the most interesting and suitable is the solution with removable dielectric.

Medical imaging and diagnostics based on microwaves

Autoři: prof. Ing. Jan Vrba, CSc., Ing. Ladislav Oppl, Ph.D., Zajíček, R., Novotná, K., Vrba, D.
Publikace: PIERS2008 in Hangzhou. Cambridge: Electromagnetics Academy, 2008. pp. 890-892. ISSN 1559-9450. ISBN 978-1-934142-00-4.
Rok: 2008

Pracoviště: Katedra elektromagnetického pole
Anotace:
Future trends in medical applications of microwave technique and technology can be seen in development of new diagnostic and imaging methods based on high frequency EM field. A significant importance for the future can be identified for the following methods: Microwave tomography, Microwave radiometry, Measurement of complex permittivity, Imaging in the Terahertz waves band and Microwave diagnostic radars.

Microwave Medical Imaging and Diagnostics

Autoři: prof. Ing. Jan Vrba, CSc., Ing. Ladislav Oppl, Ph.D., Vrba, J., Vrba, D.
Publikace: European Microwave Week 2008 "Bridging Gaps" Conference Proceedings. London: Horizon House Publications, 2008. pp. 408-411. ISBN 978-1-4244-3794-8.
Rok: 2008

Pracoviště: Katedra elektromagnetického pole
Anotace:
Future trends in medical applications of microwave technique and technology can be seen in development of new diagnostic and imaging methods based on high frequency EM field. A significant importance for the future can be identified for the following methods: Microwave tomography, Microwave radiometry, Measurement of complex permittivity, Imaging in the Terahertz waves band and Microwave diagnostic radars.

New Methods for Treatment of Atherosclerosis

Autoři: Novotná, K., prof. Ing. Jan Vrba, CSc.,
Publikace: Proceedings of the 14th Conference on Microwave Techniques COMITE 2008. Praha: Československá sekce IEEE, 2008. pp. 159-161. ISBN 978-1-4244-2137-4.
Rok: 2008

Pracoviště: Katedra elektromagnetického pole
Anotace:
Vascular diseases are the most common cause of death in present time. This project describes the design of two different types of intracavitary applicators for treatment of the atherosclerosis by microwaves. Basic principle of microwave angioplastic is, that heating gained by microwave energy irradiated into artery by microwave applicator, enables safe clear out of atherosclerotic plates in the wall of vessel.

Planar Spiral Appliator for Local Microwave Thermotherapy

Autoři: Rychlík, O., prof. Ing. Jan Vrba, CSc.,
Publikace: Proceedings of the 14th Conference on Microwave Techniques COMITE 2008. Praha: Československá sekce IEEE, 2008. pp. 271-274. ISBN 978-1-4244-2137-4.
Rok: 2008

Pracoviště: Katedra elektromagnetického pole
Anotace:
Nowadays microwave thermotherapy belongs to methods of treatment for cancer diseases.This method is often used in combination with classical therapies, which brings more success during treatment of tumors. The area is heated by microwave energy through microwave applicator. This paper deals with design, modelling and testing of planar spiral type of applicator for local microwave thermotherapy.

Prospective Applications of Microwaves in Medicine

Autoři: prof. Ing. Jan Vrba, CSc., Ing. Ladislav Oppl, Ph.D.,
Publikace: Proceedings of the 14th Conference on Microwave Techniques COMITE 2008. Praha: Československá sekce IEEE, 2008. pp. 143-146. ISBN 978-1-4244-2137-4.
Rok: 2008

Pracoviště: Katedra elektromagnetického pole
Anotace:
In this paper a technique for improvement of radiation efficiency of metamaterial zero order antenna based on increasing of vertical antenna height is presented. Result of this method is here demonstrated by comparison of the two microstrip line implementation of the zero order resonator (ZOR) antennas with different height of upper conductor above ground plane. Improved ZOR antenna exhibits 75% efficiency, while the reference antenna efficiency is 10% only.

Průmyslové aplikace mikrovlnné techniky

Autoři: Žák, O., prof. Ing. Jan Vrba, CSc.,
Publikace: Scientific Seminars - Proceedings from year 2007/2008, Volume VII, Part of the Project GACR 102/08/H018. Praha: IEEE Czechoslovakia Section, 2008. p. 11-15. ISBN 80-86582-22-1.
Rok: 2008

Pracoviště: Katedra elektromagnetického pole
Anotace:
In this paper I would like deals with microwave applicators which can be used for acceleration of processes in industrial. In particular, the applicators for microwave heating (i.e. waveguide applicators) and the heating of acid is dealt with. I would like to present theoretical models of the discussed applicators, result of numerical modeling and experimental evaluation as well. Prototypes of microwave drying and heating machine working at frequency 2.45 GHz will be reported.

Slotted Applicator for Microwave Local Hyperthermia

Autoři: Šafařík, J., prof. Ing. Jan Vrba, CSc.,
Publikace: Proceedings of the 14th Conference on Microwave Techniques COMITE 2008. Praha: Československá sekce IEEE, 2008. p. 275-278. ISBN 978-1-4244-2137-4.
Rok: 2008

Pracoviště: Katedra elektromagnetického pole
Anotace:
The object of this work is to design a microwave applicator for local thermotherapy, which is work on the principle of a slot line. The working frequency of this applicator is 434MHz. A 3D simulator of electromagnetic field is used for numeric simulation and consequential optimalization. After that, the designed applicator is made and its reflectance and specific absorption rate is measured in phantom of biologic texture. At the end of the work results of all measurements are compared to results of simulation.

Strip Microwave Applicator with Integrated Water Bolus for Local Thermotherapy

Autoři: Borovka, J., prof. Ing. Jan Vrba, CSc.,
Publikace: Scientific Seminars - Proceedings from year 2007/2008, Volume VII, Part of the Project GACR 102/08/H018. Praha: IEEE Czechoslovakia Section, 2008. p. 66-68. ISBN 80-86582-22-1.
Rok: 2008

Pracoviště: Katedra elektromagnetického pole
Anotace:
The paper deals with the desription of a prospective type of a microwave applicator for hyperthermia. The discussed applicator is made of copper and it is designed to operate in TEM mode. It is a microwave applicator for hypertermia used in cancer treatment. The size of the aperture is 120x80 mm. Numeric verification of SAR distribution in homogenous plane phantom is accomplished by means of electromagnetic field simulator SEMCAD.

System to Study the Effects of Microwave Hyperthermia on In-vivo Melanoma Model

Autoři: Togni, P., prof. Ing. Jan Vrba, CSc., Vannucci, L.
Publikace: European Microwave Week 2008 "Bridging Gaps" Conference Proceedings. London: Horizon House Publications, 2008. p. 1273-1276. ISBN 978-1-4244-3794-8.
Rok: 2008

Pracoviště: Katedra elektromagnetického pole
Anotace:
In this paper the main characteristics of a microwave system and an applicator for hyperthermia treatment of small in-vivo melanoma tumours are described. The results of temperature measurements on mice, show the possibility to design a protocol for hyperthermia treatment of small animal with superficial tumours for the evaluation of hyperthermia effects.

Theory of Evanescent Mode Applicators

Autoři: prof. Ing. Jan Vrba, CSc., Togni, P., Vrba, J., Vrba, D.
Publikace: PIERS - Progress In Electromagnetics Research Symposium - Draft Proceedings. Cambridge, MA: The Electromagnetics Academy, 2008. pp. 708-711. ISSN 1559-9450. ISBN 978-1-934142-06-6.
Rok: 2008

Pracoviště: Katedra elektromagnetického pole
Anotace:
In this contribution we describe our new reults dealing with evanescent mode waveguide hyperthermia applicators, typically used for cancer treatment. We have developed theoretical basis of this technology and designed and evaluated different versions of these applicators working below waveguide cut-of freqguency.

Waveguide Probes for Complex Permittivity Measurement

Autoři: Zajíček, R., Smejkal, T., Ing. Ladislav Oppl, Ph.D., prof. Ing. Jan Vrba, CSc.,
Publikace: Proceedings of the 14th Conference on Microwave Techniques COMITE 2008. Praha: Československá sekce IEEE, 2008. pp. 107-110. ISBN 978-1-4244-2137-4.
Rok: 2008

DOI: 10.1109/COMITE.2008.4569903
Odkaz: https://doi.org/10.1109/COMITE.2008.4569903
Pracoviště: Katedra elektromagnetického pole
Anotace:
Paper deals with complex permittivity measurement of biological tissues. Application of a waveguide probe for this measurement is shown. A nondestructive and noninvasive method based on reflection coefficient measurement attaching the material under test is used. New types of the probes are under investigation - the section of waveguide with H cross-section, the section of waveguide with the rectangular cross-section and with shorted walls, the section of waveguide with inserted dielectric wedge and finally the section of waveguide filled with liquid dielectric. Properties of these prototypes are studied in frequency range from 300 kHz to 3 GHz. FDTD method is utilized for the numerical modeling and simulation of the reflection coefficient. Results indicate that the most interesting and suitable is the solution with removable dielectric.

Analytical Solutions to the Applicators for Microwave Textile Drying by Means of Zigzag Method

Autoři: Pourová, M., prof. Ing. Jan Vrba, CSc.,
Publikace: PIERS 2007 Prague - Proceeding of Progress In Electromagnetics Research Symposium. Cambridge, MA: The Electromagnetics Academy, 2007. pp. 317-320. ISSN 1559-9450. ISBN 978-1-934142-02-8.
Rok: 2007

Pracoviště: Katedra elektromagnetického pole
Anotace:
This paper described the Zigzag method for solving microwave applicators for drying of textile materials, which is based on the solving transfer characteristics of waveguide with discontinuities. We can describe the wet textile as discontinuity by means of three quantities: the size of reflection coefficient |rho|, its phase angle phi and phase angle ψ of transmission coefficient τ. The size of the transmission coefficient is defined by known relation ττ* = 1- |rho|2 which results from the principle of conservation of energy. We created diagram of EM waves inside this structure and reached the resulting expression, which is used for calculation of electric field strength in the plane of drying textile. This quantity depends on electrical characteristics of wet textile such as permittivity and loss factor. Measurements of these dielectric properties for the coburg is complicated and this method makes it possible to solve our problem with dielectric parameter

Comparison Between Two Slot-line Applicators for Microwave Hyperthermia

Autoři: Togni, P., Dřížďal, T., prof. Ing. Jan Vrba, CSc.,
Publikace: PIERS 2007 Prague - Proceeding of Progress In Electromagnetics Research Symposium. Cambridge, MA: The Electromagnetics Academy, 2007. pp. 73. ISSN 1559-9450. ISBN 978-1-934142-02-8.
Rok: 2007

Pracoviště: Katedra elektromagnetického pole
Anotace:
This paper compares two different kinds of slot-line applicators which can be used for microwave hyperthermia treatment, one of the complex methods to treat cancer diseases. During this kind of treatment the biological tissue is exposed to electromagnetic energy in order to enhance its temperature within the range between 41°C and 45°C. The healing effects are obtained thanks to the higher thermal sensitivity of tumour tissue compared with healthy tissue.

Design and Comparison of Exposure Chambers for Verification of Microwave Influence on Biological Systems

Autoři: Víšek, L., Togni, P., prof. Ing. Jan Vrba, CSc., Ing. Ladislav Oppl, Ph.D.,
Publikace: PIERS 2007 Prague - Proceeding of Progress In Electromagnetics Research Symposium. Cambridge, MA: The Electromagnetics Academy, 2007. p. 454-458. ISSN 1559-9450. ISBN 978-1-934142-02-8.
Rok: 2007

Pracoviště: Katedra elektromagnetického pole
Anotace:
The main aim of our work is to design and simulate an exposure chamber in order to analyze the influence of electromagnetict field on mice which can simulate mobile phone emission patterns. We use two types of structures and compare their properties to find the best design for our future work.

Design and Optimization of Applicators for Microwave Cancer Treatment

Autoři: Dřížďal, T., prof. Ing. Jan Vrba, CSc.,
Publikace: Proceedings of Workshop 2007. Praha: České vysoké učení technické v Praze, 2007. pp. 476-477. ISBN 978-80-01-03667-9.
Rok: 2007

Pracoviště: Katedra elektromagnetického pole
Anotace:
Nowadays microwave cancer treatment (microwave hyperthermia) belongs to standard therapeutic methods of cancer diseases. The different thermal sensitivity of healthy a tumour tissue is used. It is important to monitor and control temperature in the treated area. First information about SAR (specific absorption rate) is given by aid of 3D simulator of electromagnetic field. The goal of this project is to investigate the thermal distribution in the treated area (include thermal conductivity and bloodstream) and the design and optimizing of microwave applicators with respect to achieve requested thermal distribution in treated area.

Evaluation of an Equipment for Cancer Treatment Using Microwave Hyperthermia

Autoři: Togni, P., Zajíček, R., Dřížďal, T., prof. Ing. Jan Vrba, CSc., Vannucci, L.
Publikace: Conference Proceedings - European Microwave Week 2007 (37th EuMC, EuRAD, EuMIC, EuWT). London: Horizon House Publications, 2007. p. 941-944. ISBN 978-2-87487-000-2.
Rok: 2007

Pracoviště: Katedra elektromagnetického pole
Anotace:
Research about interactions between EM Field and biological tissues for cancer treatment assumes every day a growing interest. In this paper we will describe the main characteristics of a microwave system developed for hyperthermic treatment and biological experiments. We will consider also some experiments on agar phantom reproducing a tumour bearing mouse, performed for a preliminary evaluation of our system.

Měření komplexní permitivity biologické tkáně

Autoři: Zajíček, R., Ing. Ladislav Oppl, Ph.D., prof. Ing. Jan Vrba, CSc., Dřížďal, T.
Publikace: Lékař a technika. 2007, 37(1), 28-32. ISSN 0301-5491.
Rok: 2007

Pracoviště: Katedra elektromagnetického pole
Anotace:
Měření komplexní permitivity biologických tkání je perspektivní metoda v lékařské diagnostice a zobrazování. Znalost komplexní permitivity v léčené oblasti, tzn. znalost komplexní permitivity zdravé a nádorové tkáně, je velmi důležitá například k nalezení (rozpoznání) nádorových buněk v lékařské diagnostice nebo pro inženýry k návrhu termoterapeutických aplikátorů. K určení dielektrických parametrů biologických tkání je vhodná odrazná metoda na otevřeném konci koaxiálního kabelu. V článku jsou shrnuty výsledky měření pomocí speciální koaxiální sondy a vektorového analyzátoru obvodů v pásmu kmitočtů od 17 MHz do 2 GHz. Měření je také modelováno v simulátoru elektromagnetického pole. Výsledky z měření a modelování jsou porovnány.

Microstrip Applicator for Local Hyperthermia

Autoři: Dřížďal, T., Togni, P., prof. Ing. Jan Vrba, CSc.,
Publikace: Proceedings - 2007 International Conference on Electromagnetics in Advanced Applications. Politecnico di Torino, 2007. ISBN 1-4244-0767-2.
Rok: 2007

Pracoviště: Katedra elektromagnetického pole
Anotace:
The possibility to use shorted circular microstrip antenna as an applicator for local hyperthermia is described in this paper. This applicator is designed to provide a local treatment on areas located on the body surface or in its proximity. The applicator is designed by aid of 3D electromagnetic field simulator SEMCAD X light at working frequency of 434 MHz. Results of impedance matching measurement and 3D SAR distributions in agar phantom show that these types of microwave applicators can be effectively used for the treatment of tumours with a diameter of approximately 4 cm.

Microwave Applicator for Treatment of Atherosclerosis

Autoři: Novotná, K., prof. Ing. Jan Vrba, CSc.,
Publikace: PIERS 2007 Prague - Proceeding of Progress In Electromagnetics Research Symposium. Cambridge, MA: The Electromagnetics Academy, 2007. p. 330-332. ISSN 1559-9450. ISBN 978-1-934142-02-8.
Rok: 2007

Pracoviště: Katedra elektromagnetického pole
Anotace:
Microwave angioplastic is one of the new domains of microwave thermotherapy, which is considered for treatment of atherosclerosis. Due to dysfunction of endothelium the sedimentation of cholesterol on a blood vessel wall can happen. This evokes its sequential closing. Basic principle of microwave angioplastic is, that heating gained by microwave energy irradiated into artery by microwave applicator, enables safe clear out of atherosclerotic plates in the wall of vessel. This paper describes the design of a special applicator for microwave angioplastic. As the most acceptable structure to create intracavitary applicator, coaxial quarter wave monopole, was chosen.

Microwave Phase Interferometry for Nondestructive Testing in Industry

Autoři: Žák, O., prof. Ing. Jan Vrba, CSc., Pourová, M.
Publikace: PIERS 2007 Prague - Proceeding of Progress In Electromagnetics Research Symposium. Cambridge, MA: The Electromagnetics Academy, 2007. p. 309-311. ISSN 1559-9450. ISBN 978-1-934142-02-8.
Rok: 2007

Pracoviště: Katedra elektromagnetického pole
Anotace:
Paper deals with a study of basic possibilities of microwave phase interferometry for nondestructive testing in industry. Special activity has been done on cases for civil engineering.

Microwave Thermotherapy for Cancer Treatment

Autoři: prof. Ing. Jan Vrba, CSc., Ing. Ladislav Oppl, Ph.D., Kvěch, J., Kubeš, J.
Publikace: PIERS 2007 Progress In Electromagnetics Research Symposium - Proceedings - CN. Cambridge, MA: The Electromagnetics Academy, 2007. pp. 643-644. ISSN 1559-9450.
Rok: 2007

Pracoviště: Katedra elektromagnetického pole
Anotace:
Paper deals with technical and clinical aspects of microwave thermotherapy.for cancer treatment.

Modelování elektromagnetického pole v mikrovlnné hypertermii

Autoři: Dřížďal, T., Zajíček, R., prof. Ing. Jan Vrba, CSc.,
Publikace: Lékař a technika. 2007, 2007(37), 11-16. ISSN 0301-5491.
Rok: 2007

Pracoviště: Katedra elektromagnetického pole
Anotace:
Výzkumy na téma interakce elektromagnetického pole s biologickými systémy jsou v popředí zájmů mnoha výzkumných pracovišť po celém světě. Mikrovlnná hypertermie, tedy léčba nádorových onemocnění pomocí řízeného mikrovlnného ohřevu biologické tkáně, dnes již patří mezi klasické metody léčby rakoviny. K přenosu mikrovlnného výkonu do léčené oblasti slouží termoterapeutické aplikátory. Základním požadavkem na úspěšnou léčbu jsou správně navržené a impedančně přizpůsobené tyto aplikátory. V článku je představeno využití 3D simulátoru elektromagnetického pole v plánování léčby pomocí mikrovlnné hypertermie, popis návrhu a realizace mikrovlnného aplikátoru včetně představení numerického řešení rozložení elektromagnetického pole a absorbovaného výkonu v léčené oblasti.

Modified Microstrip Ring Applicator for Superficial Hyperthermia

Autoři: Dřížďal, T., Togni, P., prof. Ing. Jan Vrba, CSc.,
Publikace: Proceedings of 17th International Conference Radioelektronika 2007. Brno: FEKT VUT v Brně, 2007. p. 353-355. ISBN 978-1-4244-0821-4.
Rok: 2007

Pracoviště: Katedra elektromagnetického pole
Anotace:
Nowadays Hyperthermia is one of the possible cancer treatment method used in combination with classical therapies in several countries in the world. In this article we described the designed and optimization of a microstrip type applicator for the treatment of superficial diseases. The optimization was made in order to obtain a more uniform SAR distribution, which is one of the requirements to achieve a good thermotherapy treatment.

Slot-line Applicator for Microwave Hyperthermia

Autoři: Togni, P., Dřížďal, T., prof. Ing. Jan Vrba, CSc.,
Publikace: Proceedings Book - 11th International Conference on Microwave and High Frequency Heating. Oradea: University of Oradea, 2007. p. 33-36. ISBN 978-973-759-333-7.
Rok: 2007

Pracoviště: Katedra elektromagnetického pole
Anotace:
This paper describes the possibility to use a slot-line applicator for microwave hyperthermia treatments. The healing effects are obtained thanks to the different thermal sensitivity of healthy and tumour tissue. The goal of this paper is to show that this applicator is particularly suitable to treat superficial tumours. To support this thesis, simulations has been done to predict the specific absorbed power (SAR). The results of the simulations are verified by experimental temperature measurement made with the help of a thermo-camera on a homogeneous agar phantom.

Technical Aspects of Research on Interactions between EM Field and Biological Systems

Autoři: prof. Ing. Jan Vrba, CSc., Vannucci, L., Peschke, P., Vožeh, F., Vojtíšek, M.
Publikace: PIERS 2007 Progress In Electromagnetics Research Symposium - Proceedings - CN. Cambridge, MA: The Electromagnetics Academy, 2007. pp. 641-642. ISSN 1559-9450.
Rok: 2007

Pracoviště: Katedra elektromagnetického pole
Anotace:
Paper deals with technical aspects of the research of interactions of EM field with biological systems. Different types of microwave applicators are described - i.e for the study of the so called thermal resp. nonthermal effects.

Workstation for Medical Diagnostics Based on Dielectric Properties Measurement of Biological Tissue

Autoři: Zajíček, R., Ing. Ladislav Oppl, Ph.D., prof. Ing. Jan Vrba, CSc.,
Publikace: Proceedings of Workshop 2007. Praha: České vysoké učení technické v Praze, 2007. pp. 478-479. ISBN 978-80-01-03667-9.
Rok: 2007

Pracoviště: Katedra elektromagnetického pole
Anotace:
This paper describes a method for determining the dielectric constant of a biological tissue. A suitable way to make a dielectric measurement that is nondestructive and noninvasive for the biological substance and broadband at the frequency range of the network analyzer is to use a reflection method on an open ended coaxial line. A coaxial probe in the frequency range of the network analyzer from 300 kHz to 3 GHz is under investigation and also a calibration technique and the behavior of discrete elements in an equivalent circuit of an open ended coaxial line. Information about the magnitude and phase of the reflection coefficient on the interface between a biological tissue sample and a measurement probe is modeled with the aid of an electromagnetic field simulator. The numerical modeling is compared with real measurements, and a comparison is presented.

Aplikace mikrovlnného ohřevu v textilním průmyslu

Autoři: Pourová, M., prof. Ing. Jan Vrba, CSc.,
Publikace: Book of Proceedings VRŠOV 2006. Brno: VUT v Brně, Fakulta elektrotechniky a komunikačních technologií, 2006. pp. 141-144. ISBN 80-214-3247-0.
Rok: 2006

Pracoviště: Katedra elektromagnetického pole
Anotace:
Ve spolupráci s Výzkumným ústavem textilních strojů a Technickou universitou v Liberci jsme vyvinuli aplikátor pro mikrovlnné vysoušení látek ve výrobním procesu. Tento aplikátor pracuje na principu otevřeného rezonátoru a jeho pracovní frekvence je 2,45GHz. Mikrovlnné vysoušení textilií je ovlivňováno především dielektrickými vlastnostmi textilií, které se mění v závislosti na obsahu vlhkosti a teplotním rozložení. Hlavním cílem této práce je optimalizace navrženého aplikátoru a vytvoření analytického modelu, pomocí něhož bude navržen postup optimálního naladění rezonanční dutiny aplikátoru s vysoušenou látkou uvnitř.

Dielectric Constant Measurement of Biological Tissues

Autoři: Zajíček, R., prof. Ing. Jan Vrba, CSc., Pourová, M.
Publikace: Lékař a technika. 2006, 36(2/2006), 195-201. ISSN 0301-5491.
Rok: 2006

Pracoviště: Katedra elektromagnetického pole
Anotace:
This paper describes a method for the determination of dielectric constant of a biological tissue. For the dielectric measurement which should be nondestructive and noninvasive for the biological substance and broadband at frequency range of network analyzer is convenient a reflection method on an open ended coaxial line. A coaxial probe in the frequency range of network analyzer from 20 MHz to 2 GHz is under investigation and also a calibration technique and the behaviour of discrete elements in an equivalent circuit of an open ended coaxial line. Information about magnitude and phase of reflection coefficient on interface between a biological tissue and probe is modeled by aid of electromagnetic field simulator. The numerical modeling is compared with real measurements. Comparison is presented as well.

Evaluation f a Reflection Method on an Open-Ended Coaxial Line and its Use in Dielectric Measurements

Autoři: Zajíček, R., prof. Ing. Jan Vrba, CSc., Novotný, K.
Publikace: Acta Polytechnica. 2006, 46(5), 50-54. ISSN 1210-2709.
Rok: 2006

Pracoviště: Katedra elektromagnetického pole
Anotace:
This paper describes a method for determining the dielectric constant of a biological tissue. A suitable way to make a dielectric measurement that is nondestructive and noninvasive for the biological substance and broadband at the frequency range of the network analyzer is to use a reflection method on an open ended coaxial line. A coaxial probe in the frequency range of the network analyzer from 17 MHz to 2 GHz is under investigation and also a calibration technique and the behavior of discrete elements in an equivalent circuit of an open ended coaxial line. Information about the magnitude and phase of the reflection coefficient on the interface between a biological tissue sample and a measurement probe is modeled with the aid of an electromagnetic field simulator. The numerical modeling is compared with real measurements, and a comparison is presented.

Measurement of Dielectric and Temperature Properties of Chemicals

Autoři: Zajíček, R., Ing. Ladislav Oppl, Ph.D., prof. Ing. Jan Vrba, CSc.,
Publikace: Radioelektronika 2006 - Conference Proceedings. Bratislava: Slovak University of Technology, 2006. pp. 386-389. ISBN 80-227-2388-6.
Rok: 2006

Pracoviště: Katedra elektromagnetického pole
Anotace:
Every material has a unique set of electrical characteristics that depend on its dielectric properties. This paper describes a method for dielectric measurements of chemicals. The well known reflection method by measuring on an open ended coaxial line has been modified for convenient determination of dielectric parameters of some agressive substances which are important for industrial applications. The temperature dependence of these parameters was also under investigation.

Microwave Drying of Textile Materials and Optimization of a Resonant Applicator

Autoři: Pourová, M., prof. Ing. Jan Vrba, CSc.,
Publikace: Acta Polytechnica. 2006, 46(5), 3-7. ISSN 1210-2709.
Rok: 2006

Pracoviště: Katedra elektromagnetického pole
Anotace:
The principal aim of this work was to design and optimize the open-resonator type applicator for microwave drying. The whole system works at frequency 2.45 GHz and it is intended for use in drying in factory production of fabrics. After identifying of the basic arrangement of the microwave drying machine, it was used the electromagnetic field simulator. We found the distribution of the electric field strength in drying textiles in this way. In parallel, we analyzed the drying system with analytical calculations. We created a diagram of the EM waves inside this structure and reached the resulting expression for use in calculating the electric field intensity in the plane of the drying textile. This quantity depends on the dielectrical characteristics of wet textiles. We have results of distribution SAR, results of measurements of the moisture content in the dried textile with respect to time. These results are important for subsequent optimization of the efficiency of the whole machine.

Microwave Drying of Textile Materials and Optimization of Resonant Applicator

Autoři: Pourová, M., prof. Ing. Jan Vrba, CSc.,
Publikace: Advanced Engineering Design AED 2006. Praha: České vysoké učení technické v Praze, 2006. ISBN 80-86059-44-8.
Rok: 2006

Pracoviště: Katedra elektromagnetického pole
Anotace:
The principal intent of this work was design and optimization of applicator for microwave drying. Applicator is derived from the Fabry-Perrot resonator. Whole system works at frequency 2.45 GHz. This machine is intended for the drying at factory production of fabrics. At the first part of design we determined position of magnetron and we found out distribution of electric field strength in drying textile by EM-simulator. At the second part we analyzed drying system with the numerical calculation. We created diagram of EM waves inside this structure and reached the resulting expression using for calculation of electric field strength in the plane of drying textile. This quantity depends on electrical characteristics of wet textile such as permittivity and loss factor. We have results of distribution SAR, results of measurements of the moisture content in the dried textile with respect to time. These acquired results are important for the next optimization of efficiency whole machine.

Microwave Medical Imaging

Autoři: prof. Ing. Jan Vrba, CSc., Ing. Ladislav Oppl, Ph.D., Trefná, H., Pourová, M., Dřížďal, T., Zajíček, R.
Publikace: Advanced Engineering Design AED 2006. Praha: České vysoké učení technické v Praze, 2006. ISBN 80-86059-44-8.
Rok: 2006

Pracoviště: Katedra elektromagnetického pole
Anotace:
Future trends in medical applications of microwave technique and technology can be seen in development of new diagnostic and imaging methods based on high frequency EM field. A significant importance for the future can be identified for the following methods: Microwave tomography, Microwave radiometry, Measurement of complex permittivity, Imaging in the Terahertz waves band and Microwave diagnostic radars.

Microwave System for Drying of Textile: Design, Model and Evaluation

Autoři: Pourová, M., prof. Ing. Jan Vrba, CSc., Žák, O.
Publikace: ARFTG - 68th Microwave Measurements Conference - Proceedings. Piscataway: IEEE, 2006. p. 110-116.
Rok: 2006

Pracoviště: Katedra elektromagnetického pole
Anotace:
In this paper we describe our new results dealing with design, modeling and evaluation of microwave industrial applicators used for drying of textile materials. We have designed and evaluated two different types of these applicators: open-resonator-type and waveguide-type one. We describe here basic analytical models of the discussed applicators, results of numerical modeling and experimental evaluation as well. Prototype of microwave drying machine working with microwave power of 17 kW at frequency 2.45 GHz is reported.

Microwave Textile Drier

Autoři: prof. Ing. Jan Vrba, CSc., Pourová, M., Žák, O., Vrba, J.jr.
Publikace: Proceedings of Mediterranean Microwave Symposium 2006. Pavia: University of Pavia, 2006. p. 555-558.
Rok: 2006

Pracoviště: Katedra elektromagnetického pole
Anotace:
In this paper we describe our new results dealing with microwave industrial applicators used for drying of textile materials. We have designed and evaluated two different types of these applicators: open-resonator-type and waveguide-type one. We describe here basic analytical models of the discussed applicators, results of numerical modelling and experimental evaluation as well. Prototype of microwave drying machine working at frequency 2.45 GHz is reported.

Possibilities of Waveguide Applicatiors Utilization for Drying in Textile Industry

Autoři: Pourová, M., Žák, O., prof. Ing. Jan Vrba, CSc., Richter, A.
Publikace: Proceeding of the 13th International Conference: Structure and Structural Mechanics of Textiles. Liberec: Technická univerzita v Liberci, 2006. pp. 469-474. ISBN 80-7372-135-X.
Rok: 2006

Pracoviště: Katedra elektromagnetického pole
Anotace:
In this paper we describe possibilities of microwave energy utilization for drying or heating materials in the textile industry. We have designed several waveguide types of microwave industrial applicators. We describe here basic model waveguide applicator, results of numerical modeling and experimental measurement of drying characteristic and also another modification of this applicator. These industry applicators work at frequency 2.45GHz

Research of EM Field and Living Systems Interactions

Autoři: prof. Ing. Jan Vrba, CSc., Vannucci, L., Peschke, P., Vožeh, F., Vojtíšek, M., Kubeš, J., Herza, J., Cvek, J., Dřížďal, T., Zajíček, R.
Publikace: Advanced Engineering Design AED 2006. Praha: České vysoké učení technické v Praze, 2006. ISBN 80-86059-44-8.
Rok: 2006

Pracoviště: Katedra elektromagnetického pole
Anotace:
Research of interactions between EM Field and biological systems is of growing interests elsewhere. Also here in Czech Republic there are several groups working in this field, often in international co-operations. We will describe here mainly basic technical equipment developed for 5 different research projects in the discussed area of interactions of EM field and biological systems.

Technical Equipment for Research of Biological Effects of EM Field

Autoři: prof. Ing. Jan Vrba, CSc., Vannucci, L., Peschke, P., Dřížďal, T., Zajíček, R.
Publikace: Proceedings of the 36th European Microwave Conference. Piscataway: IEEE, 2006. p. 1197-1200. ISBN 2-9600551-6-0.
Rok: 2006

Pracoviště: Katedra elektromagnetického pole
Anotace:
Research of interactions between EM Field and biological systems is of growing interests elsewhere. Also here in Czech Republic there are several groups working in this field, often in international co-operations. We will describe here mainly basic technical equipment developed for 5 different research projects in the discussed area of interactions of EM field and biological systems.

Technical Equipment for Research of Biological Effects of EM Field

Autoři: prof. Ing. Jan Vrba, CSc., Vannucci, L., Peschke, R., Zajíček, R., Vrba, J.jr., Dřížďal, T.
Publikace: Proceedings of Mediterranean Microwave Symposium 2006. Pavia: University of Pavia, 2006. p. 56-59.
Rok: 2006

Pracoviště: Katedra elektromagnetického pole
Anotace:
Research of interactions between EM Field and biological systems is of growing interests elsewhere. Also here in Czech Republic there are several groups working in this field, often in international co-operations. We will describe here mainly basic technical equipment developed for 5 different research projects in the discussed area of interactions of EM field and biological systems.

Technické zázemí pro studium tepelných účinků elektromagnetického pole v biologických experimentech

Autoři: Zajíček, R., Herza, J., prof. Ing. Jan Vrba, CSc., Vannucci, L., Dřížďal, T.
Publikace: Book of Proceedings VRŠOV 2006. Brno: VUT v Brně, Fakulta elektrotechniky a komunikačních technologií, 2006. pp. 220-223. ISBN 80-214-3247-0.
Rok: 2006

Pracoviště: Katedra elektromagnetického pole
Anotace:
Výzkumy na téma interakce elektromagnetického pole s biologickými systémy jsou v popředí zájmů mnoha výzkumných pracovišť po celém světě. Katedra elektromagnetického pole ČVUT v Praze zajišťuje technickou podporu pro biologické experimenty zkoumající vlivy elmag. pole na živé tkáně. V článku je představena spolupráce Katedry s Mikrobiologickým ústavem AV ČR. Experiment zkoumá tepelné účinky elmag. pole na maligní melanom implantovaný v myši. K transformaci mikrovlnné energie z generátoru, který pracuje na kmitočtu 2,45 GHz, je použit vlnovodný aplikátor obdélníkového průřezu. Tento článek prezentuje technickou realizaci a získané teplotní průběhy.

The Effect of 1800 MHz Electromagnetic Radiation Exposure on Cortical and Hipocampal Electrogeny in Neurodefective and Healthy Brain

Autoři: Barcal, J., prof. Ing. Jan Vrba, CSc., Vožeh, F.
Publikace: Proceedings of Biological Effects of EMFs - 4th International Workshop. Crete: University of Ioannina, 2006. pp. 784-793. ISBN 960-233-173-9.
Rok: 2006

Pracoviště: Katedra elektromagnetického pole
Anotace:
The Effect of 1800 MHz Electromagnetic Radiation Exposure on Cortical and Hipocampal Electrogeny in Neurodefective and Healthy Brain is studied in this paper. Technical equipment used for the experiments is being described.

The Effect of High Frequency Electromagnetic Field on Some Somatic and Nervous Characteristics in Healthy and Neurodefective Mice

Autoři: Vožeh, F., Doněk, A., Cendelín, J., Korelusová, I., prof. Ing. Jan Vrba, CSc.,
Publikace: Proceedings of Biological Effects of EMFs - 4th International Workshop. Crete: University of Ioannina, 2006. pp. 1241-1249. ISBN 960-233-173-9.
Rok: 2006

Pracoviště: Katedra elektromagnetického pole
Anotace:
Paper deals with the Effect of High Frequency Electromagnetic Field on Some Somatic and Nervous Characteristics in Healthy and Neurodefective Mice and it describes technical equipment used for that experiments.

The Evaluation of Reflection Method on an Open Ended Coaxial Line and its use in Dielectric Measurement

Autoři: Zajíček, R., prof. Ing. Jan Vrba, CSc., Novotný, K.
Publikace: Advanced Engineering Design AED 2006. Praha: České vysoké učení technické v Praze, 2006. ISBN 80-86059-44-8.
Rok: 2006

Pracoviště: Katedra elektromagnetického pole
Anotace:
This paper describes a method for determination of dielectric constant of a biological tissue. For the dielectric measurement which should be nondestructive and noninvasive for the biological substance and broadband at frequency range of network analyzer is convenient a reflection method on an open ended coaxial line. A coaxial probe in the frequency range of network analyzer from 20 MHz to 2 GHz is under investigation and also a calibration technique and the behaviour of discrete elements in an equivalent circuit of an open ended coaxial line. Information about magnitude and phase of reflection coefficient on interface between a biological tissue and measurement probe is modeled by aid of electromagnetic field simulator. The numerical modeling is compared with real measurements. Comparison is presented as well.

Thermal Distribution of the Lucite Cone Applicator for Microwave Thermotherapy

Autoři: Dřížďal, T., prof. Ing. Jan Vrba, CSc.,
Publikace: Conference Proceedings - MIKON 2006. Warsaw: Telecommunication Research Institute, 2006. p. 459-462. ISBN 83-906662-7-8.
Rok: 2006

DOI: 10.1109/MIKON.2006.4345217
Odkaz: https://doi.org/10.1109/MIKON.2006.4345217
Pracoviště: Katedra elektromagnetického pole
Anotace:
Microwave thermotherapy is being used for cancer treatment. The treatment area is heated by microwave energy, which irradiated from microwave applicator. As an applicator we can use the waveguides and their possible modifications. This paper describes simulated and measured thermal distributions of the lucite cone applicator, which is composed from feeding waveguide and strip line horn (lateral faces are from dielectric material). The simulations and measurements of the impedance matching are presented as well.

Thermal Simulations and Measurement of the Waveguide Strip Horn Applicator for Microwave Thermotherapy

Autoři: Dřížďal, T., prof. Ing. Jan Vrba, CSc.,
Publikace: Radioelektronika 2006 - Conference Proceedings. Bratislava: Slovak University of Technology, 2006. pp. 308-311. ISBN 80-227-2388-6.
Rok: 2006

Pracoviště: Katedra elektromagnetického pole
Anotace:
Microwave thermotherapy is one of the possibilities to treat cancer diseases. The treatment area is heated by microwave energy, which irradiated from microwave applicator. As a microwave applicator we can use several different forms (waveguides, microstrips, etc.). This paper describes simulations and measurements of thermal distributions of strip line horn applicator, which is composed from feeding waveguide and strip horn (lateral faces are from dielectric material).

Waveguide Applicators for Microwave Medical Diagnostics and Treatment

Autoři: prof. Ing. Jan Vrba, CSc., Dřížďal, T., Vrba, J.jr., Zajíček, R.
Publikace: Proceedings of Mediterranean Microwave Symposium 2006. Pavia: University of Pavia, 2006. pp. 231-234.
Rok: 2006

Pracoviště: Katedra elektromagnetického pole
Anotace:
Future trends in medical applications of microwave technique and technology can be seen in development of new diagnostic and imaging methods based on high frequency EM field. A significant importance for the future can be identified for the following methods: Microwave tomography, Microwave radiometry, Measurement of complex permittivity, Imaging in the Terahertz waves band and Microwave diagnostic radars.

Applicator for the Treatment of the Deep Seated Tumours - Numerical Simulations

Autoři: Trefná, H., prof. Ing. Jan Vrba, CSc.,
Publikace: The 13th Conference on Microwave Techniques - COMITE 2005. Praha: IEEE Czechoslovakia Section, 2005. pp. 219-222. ISBN 80-86582-16-7.
Rok: 2005

Pracoviště: Katedra elektromagnetického pole
Anotace:
Regional thermotherapy is one of prospective modalities of microwave thermotherapy. Its basic principle is to generate a converging elliptic wave. Goal of this project is to develop new type of regional applicator compatible with non-invasive thermometry.

Applicator for Treatment of Deep Seated Tumours

Autoři: Trefná, H., prof. Ing. Jan Vrba, CSc.,
Publikace: The 3rd European Medical and Biological Engineering Conference - EMBEC´05. Praha: Společnost biomedicínského inženýrství a lékařské informatiky ČLS JEP, 2005. ISSN 1727-1983.
Rok: 2005

Pracoviště: Katedra elektromagnetického pole
Anotace:
A model of a new type of applicator for microwave thermotherapy, compatible with noninvasive thermometry was developed and evaluated.The goal of this paper is to validate theoretical assumptions for using the applicator in regional thermotherapy.Radiating elements of this applicator are 8 inductive loops tuned to resonance by capacitive elements. Details of the applicator's realization and ability to focus elecromagnetic (EM) energy in the phantom of biological tissue by employing various number of elements are presented. Possibilities of focusing EM energy in an arbitrary part of phantom of biological tissue using phase and amplitude shift at the feed-points of the elements are described. Preliminary measurements of the model and comparison with simulated results aremade. Further refinement of numerical models and measuring methods are necessary.

Arrays of Waveguide Applicators for Microwave Thermotherapy

Autoři: prof. Ing. Jan Vrba, CSc., Chovanec, R., Trefná, H., Herza, J., Kvěch, J., Kubeš, J.
Publikace: PIERS 2005. Cambridge, MA: The Electromagnetics Academy, 2005.
Rok: 2005

Pracoviště: Katedra elektromagnetického pole
Anotace:
Paper deals with possibility to create an array from waveguide applicators in order to create so called regional aplicator, which can be used for deep treatment either by homogeneous heating of the treated area or to focus microwave energy into small area.

Clinical Experience with Local Microwave Hyperthermia

Autoři: Ing. Ladislav Oppl, Ph.D., prof. Ing. Jan Vrba, CSc., Kubeš, J., Kvěch, J.
Publikace: The 13th Conference on Microwave Techniques - COMITE 2005. Praha: IEEE Czechoslovakia Section, 2005. pp. 275-278. ISBN 80-86582-16-7.
Rok: 2005

Pracoviště: Katedra elektromagnetického pole
Anotace:
Local microwave hyperthermia in combination with other treatment methods (mainly with radiotherapy) represents very effective treatment of cancer. In this paper a technical equipment used for the hyperthermia treatment is described and our 24 years old experience with this method in the Institute of Radiation Oncology in Prague is presented.

Comparison of Applicators for Microwave Drying of Textile Materials

Autoři: Pourová, M., Žák, O., prof. Ing. Jan Vrba, CSc., Herza, J.
Publikace: The 13th Conference on Microwave Techniques - COMITE 2005. Praha: IEEE Czechoslovakia Section, 2005. pp. 299-302. ISBN 80-86582-16-7.
Rok: 2005

Pracoviště: Katedra elektromagnetického pole
Anotace:
In this contribution, we would like to present our results discussing about comparison between two types of single-mode microwave industrial applicators used for microwave drying of textile. The first applicator works on the open-resonator principle and the second one is a waveguide-type applicator. Both applicators are designed to work at frequency 2.45GHz and we use magnetron like source with power 800W. We would like to show results of numerical modelling and experimental evaluation of the mentioned applicators.

Feasibility Study of Microstrip Ring Applicator for Microwave Thermotherapy

Autoři: Dřížďal, T., prof. Ing. Jan Vrba, CSc., Zajíček, R.
Publikace: The 13th Conference on Microwave Techniques - COMITE 2005. Praha: IEEE Czechoslovakia Section, 2005. pp. 223-226. ISBN 80-86582-16-7.
Rok: 2005

Pracoviště: Katedra elektromagnetického pole
Anotace:
This paper describes a new type of applicator for local microwave thermotherapy - a microstrip ring applicator. The advantages of applicator are from technical aspect firstly possibility to mould a thermal distribution of microwave energy in treatment area and easy construction too. From medical aspect the applicator can be used in treatment of difficult situated tumours which couldn't been treated by waveguide applicators. Further important applicator's advantage is that it has form and weight which don't stressed patient. An applicator design was done at operating frequency 434 MHz. An impedance matching and SAR - 3D distribution were studied in electromagnetic field simulator. Results are presented as well.

Future Trends in Medical Appliations of Microwaves: Microwave Imaging and Diagnostics

Autoři: prof. Ing. Jan Vrba, CSc.,
Publikace: Radioelektronika 2005 - Conference Proceedings. Brno: VUT v Brně, FEI, Ústav radioelektroniky, 2005. pp. 254-258. ISBN 80-214-2904-6.
Rok: 2005

Pracoviště: Katedra elektromagnetického pole
Anotace:
Work deals with Future Trends in Medical Appliations of Microwaves. especially focussed on Microwave Imaging and Diagnostics.

Hybrid Applicator for Thermotherapy

Autoři: Dřížďal, T., prof. Ing. Jan Vrba, CSc.,
Publikace: Radioelektronika 2005 - Conference Proceedings. Brno: VUT v Brně, FEI, Ústav radioelektroniky, 2005. pp. 413-416. ISBN 80-214-2904-6.
Rok: 2005

Pracoviště: Katedra elektromagnetického pole
Anotace:
This paper deals with hybrid applicator for microwave termotherapy, which is designed for working frequency 434 MHz. Applicator was optimized by the help of simulator of electromagnetic field, made and measured by vector analyzer.

Measurement of Biological Tissue Dielecric Properties

Autoři: Zajíček, R., prof. Ing. Jan Vrba, CSc.,
Publikace: Radioelektronika 2005 - Conference Proceedings. Brno: VUT v Brně, FEI, Ústav radioelektroniky, 2005. pp. 502-505. ISBN 80-214-2904-6.
Rok: 2005

Pracoviště: Katedra elektromagnetického pole
Anotace:
The paper describes a method for the measurement of biological tissue dielectric properties. For this purpose is optimal the reflection measurement method on an open-ended coaxial line. The real measurement situation is modelled in the electromagnetic field simulator. Comparision of simulated and measured data are presented as well.

Measurement of Dielectric Properties of Biological Tissue

Autoři: Ing. Ladislav Oppl, Ph.D., Zajíček, R., prof. Ing. Jan Vrba, CSc.,
Publikace: ESHO 2005 - Book of Abstracts. Graz: Medical University of Graz, Department of Surgery, 2005. p. 90-92.
Rok: 2005

Pracoviště: Katedra elektromagnetického pole
Anotace:
The paper describes a method for the measurement of biological tissue dielectric properties at radio frequency band in the range of 20 to 2000 MHz. For this purpose it is optimal to use the reflection measurement method on an open-ended coaxial line. It is a noninavsive measurement method. The real measurement situation is modelled in the electromagnetic field simulator. Comparision of simulated and measured data are presented as well.

Medical Applications of Microwaves

Autoři: prof. Ing. Jan Vrba, CSc.,
Publikace: Electromagnetic Biology and Medicine. 2005, 24(3), 441-448. ISSN 1536-8378.
Rok: 2005

Pracoviště: Katedra elektromagnetického pole
Anotace:
Medical applications of microwaves (i.e. a possibility to use microwave energy for therapeutical purposes) are a quite new and a very rapidly developing field. Microwave thermotherapy is being used in medicine for the cancer treatment and treatment of some other diseases since early eighties. In this contribution we would like to offer general overview of present activities in the Czech Republic, i.e. clinical applications and results, technical aspects of thermo therapeutic equipment and last but not least, prospective diagnostics based on microwave principals ant technology and instrumentation

Měření komplexní permitivity biologické tkáně

Autoři: Zajíček, R., prof. Ing. Jan Vrba, CSc.,
Publikace: Odborné semináře - Sborník za rok 2004/2005. Praha: Československá sekce IEEE, 2005. pp. 40-43. ISBN 80-86582-17-5.
Rok: 2005

Pracoviště: Katedra elektromagnetického pole
Anotace:
Tento seminář popisuje pracoviště pro měření komplexní permitivity biologické tkáně "in vivo" v pásmu od 20 MHz do 2 GHz. Pro tento účel je optimální odrazná metoda na otevřeném konci koaxiálního vedení. Její princip spočívá v tom, že otevřený konec koaxiálního vedení mění svůj činitel odrazu v závislosti na dielektrických vlastnostech materiálu, který je k němu přiložen. Je to metoda nedestruktivní a neinvazivní. Situace z měření je modelována v simulátoru eletromagnetického pole. Ten poskytuje informace o amplitudě a fázi činitele odrazu elektromagnetické vlny na rozhraní měřicí senzor a biologická tkáň. Měření se uskutečnilo pomocí sixportového měřiče odrazů a ze získaných hodnot byla určena komplexní permitivita biologické tkáně pomocí náhradního obvodu otevřeného konce koaxiálního vedení. V závěru semináře jsou porovnány a zhodnoceny výsledky z měření a modelování v simulátoru elektromagnetického pole.

Method of Measuring Dielectric Properties of Biological Tissue and its use in Medical Imaging and Diagnostic

Autoři: Zajíček, R., Ing. Ladislav Oppl, Ph.D., prof. Ing. Jan Vrba, CSc.,
Publikace: The 3rd European Medical and Biological Engineering Conference - EMBEC´05. Praha: Společnost biomedicínského inženýrství a lékařské informatiky ČLS JEP, 2005. ISSN 1727-1983.
Rok: 2005

Pracoviště: Katedra elektromagnetického pole
Anotace:
Every material has a unique set of electrical charakteristics that are dependent on its dielectric properties. This paper describes a method for dielectric measurements of biological tissue and shows possibilities o use this method in medical imaging and diagnostics. A reflection method on an open ended coaxial line is a nondestructive and noninvasive measurement method which exclusively offers possibilities for "in vivo" as well as "in vitro" measurements. The real meausrement situation is modelled in an electromagnetic field simulator. Comparison of simulated and measured date are presented as well.

Microwave Applicator for Deep Local Microwave Thermotherapy: Agreement Between "SAR" Numerical Simulations and Measurements

Autoři: Herza, J., prof. Ing. Jan Vrba, CSc., Cvek, J., Chovanec, R.
Publikace: The 13th Conference on Microwave Techniques - COMITE 2005. Praha: IEEE Czechoslovakia Section, 2005. pp. 227-230. ISBN 80-86582-16-7.
Rok: 2005

Pracoviště: Katedra elektromagnetického pole
Anotace:
This paper is focused on the design and evaluation of microwave applicator for deep local thermotherapy by aid of the EM numerical simulations and its evaluation by SAR measurements in the water phantom (using special EM field sensors).

Microwave Applicators for "BPH" Thermotherapy

Autoři: Hlaváč, R., prof. Ing. Jan Vrba, CSc.,
Publikace: The 3rd European Medical and Biological Engineering Conference - EMBEC´05. Praha: Společnost biomedicínského inženýrství a lékařské informatiky ČLS JEP, 2005. ISSN 1727-1983.
Rok: 2005

Pracoviště: Katedra elektromagnetického pole
Anotace:
Paper deals with new results in the field of intracavitary microwave applicators used for Benign Prostatic Hyperplasia (BPH) treatment. Costs and risks associated with clasical BPH treatment (TURP and open surgery) have promoted the development of minimally invasive methods. Microwave thermotherapy, varying forms of laser treatment, transurethral needle ablation, etc. have all been developed in the 1990s. The underlying principle behind these methods is to coagulate prostatic adenomatous tissue by means of heat. Of all the available minimal invasive treatment modalities, transurethral microwave is one of the most wide spread at present [1].

Microwave Applicators for Medical Applications: Imaging and Thermotherapy Treatment

Autoři: prof. Ing. Jan Vrba, CSc.,
Publikace: Microwave Review. 2005, 11(1), 43-46. ISSN 1450-5835.
Rok: 2005

Pracoviště: Katedra elektromagnetického pole
Anotace:
Paper deals with our new results in the field of waveguide and intracavitary applicators used for microwave thermotherapy, like e.g. cancer treatment, physiotherapy, benign prostatic hyperplasia (BPH) treatment, etc.

Microwave Drying Machine for Textile Materials

Autoři: prof. Ing. Jan Vrba, CSc., Stejskal, M., Klepl, R., Richter, A., Pourová, M., Žák, O., Herza, J., Ing. Ladislav Oppl, Ph.D.,
Publikace: European Microwave Week 2005 Conference Proceedings. London: Horizon House Publications, 2005. pp. 1051-1054. ISBN 2-9600551-2-8.
Rok: 2005

Pracoviště: Katedra elektromagnetického pole
Anotace:
In this paper we describe our new results dealing with microwave industrial applicators used for drying of textile materials. We have designed and evaluated two different types of these applicators: open-resonatortype and waveguide-type one. We describe here basic models of the discussed plicators, results of numerical modelling and experimental evaluation as well. Prototype of microwave drying machine working at frequency 2.45 GHz is reported.

Microwave Medical Imaging and Diagnostics

Autoři: prof. Ing. Jan Vrba, CSc., Ing. Ladislav Oppl, Ph.D., Trefná, H., Žák, O., Pourová, M., Dřížďal, T., Zajíček, R.
Publikace: The 3rd European Medical and Biological Engineering Conference - EMBEC´05. Praha: Společnost biomedicínského inženýrství a lékařské informatiky ČLS JEP, 2005. ISSN 1727-1983.
Rok: 2005

Pracoviště: Katedra elektromagnetického pole
Anotace:
Future trends in medical applications of microwave technique and technology can be seen in development of new diagnostic and imaging methods based on high frequency em field. A significant importance for the future can be identified for the following methods: microwave tomography, microwave radiometry, measurement of complex permittivity, imaging in the terahertz waves band and microwave diagnostic radars.

Modelování elektromagnetického pole v biologických pokusech a jejich technická realizace

Autoři: Zajíček, R., Dřížďal, T., prof. Ing. Jan Vrba, CSc., Vojtíšek, M.
Publikace: Sborník příspěvků konference Vršov 2005. Brno: VUT v Brně, FEKT, 2005. pp. 180-183. ISBN 80-214-3008-7.
Rok: 2005

Pracoviště: Katedra elektromagnetického pole
Anotace:
Ve spolupráci se Státním zdravotním ústavem (SZÚ) v Praze vznikla potřeba realizovat technické zázemí pokusů a modelovat rozložení specifického absorbovaného výkonu v biologických experimentech projektu s názvem "Elektromangetická pole a propustnost bariéry krev-mozek vůči kovům". Na laboratorních zvířatech (potkanech) se zkoumá vliv elektromagnetického záření o frekvenci 1800 MHz na propustnost kovů (mangan, kadmium) přes bariéru krev-mozek. Úkolem inženýra je v tomto projektu navhnout anténu pro expoziční stanici pokusů a pomocí numerického modeloávní prezentovat rozložení specifického absorbovaného výkonu (SAR) a dále rozložení intenzity EM pole.

Modifications of the Waveguide-Horn Applicator for Microwave Thermotherapy

Autoři: Dřížďal, T., prof. Ing. Jan Vrba, CSc.,
Publikace: The 13th Conference on Microwave Techniques - COMITE 2005. Praha: IEEE Czechoslovakia Section, 2005. pp. 279-282. ISBN 80-86582-16-7.
Rok: 2005

Pracoviště: Katedra elektromagnetického pole
Anotace:
This paper deals with possibility to achieve larger thermal distribution area using waveguide-horn applicator. Three applicators for local thermotherapy working at the 434 MHz were designed. One applicator was made and measured. The impedance matching and the SAR thermal distribution were measured in the agar phantom. The results of simulations and measurements are compared as well.

Optimize Tuning of Resonant Cavity in Applicator for Microwave Drying of Textile

Autoři: Pourová, M., prof. Ing. Jan Vrba, CSc.,
Publikace: The 13th Conference on Microwave Techniques - COMITE 2005. Praha: IEEE Czechoslovakia Section, 2005. pp. 295-298. ISBN 80-86582-16-7.
Rok: 2005

Pracoviště: Katedra elektromagnetického pole
Anotace:
At present microwave heating is exploited in many sector of industry. In cooperation with Research Institute of Textile Machines Liberec we developed applicator for microwave drying of textile in manufacturing, which is working on the open resonator principle. The purpose of the present work is to investigate influence of dielectric properties of textile materials on the tuning of resonant cavity of discussed applicator (numerical simulation and the analyses of the electric field strength in the plate of textile)

Regional Applicator Compatible with Non-invasive Temperature Measurements

Autoři: Trefná, H., prof. Ing. Jan Vrba, CSc.,
Publikace: Radioelektronika 2005 - Conference Proceedings. Brno: VUT v Brně, FEI, Ústav radioelektroniky, 2005. pp. 259-261. ISBN 80-214-2904-6.
Rok: 2005

Pracoviště: Katedra elektromagnetického pole
Anotace:
Regional thermotherapy is one of domain of microwave trermotherapy, which basic principle is generating a converging elliptic wave. Goal of this project is the developing of regional applicator compatible with non-invasive thermometry.

Special Applicator for Microwave Thermotherapy

Autoři: Dřížďal, T., prof. Ing. Jan Vrba, CSc.,
Publikace: Abstract Book - Fröhlich Centenary International Symposim Coherence and Electromagnetic Fields in Biological Systems. Praha: AV ČR, Ústav radiotechniky a elektroniky, 2005. pp. 160-161. ISBN 80-86269-13-2.
Rok: 2005

Pracoviště: Katedra elektromagnetického pole
Anotace:
This paper deals with applicator for local thermotherapy, which works at the frequency 434 MHz. Applicator is composed from feeding waveguide and strip horn, which has got lateral faces from PVC. Applicator was designed, made and measured. The impedance matching and the SAR distribution were measured in the agar phantom. The results of simulations and measurements are compared as well.

Technical Equipment for Research of EM Field and Biological Systems Interactions

Autoři: prof. Ing. Jan Vrba, CSc., Vannucci, L., Peschke, P., Vožeh, F., Vojtíšek, M., Kubeš, J., Herza, J., Cvek, J., Dřížďal, T., Zajíček, R.
Publikace: The 3rd European Medical and Biological Engineering Conference - EMBEC´05. Praha: Společnost biomedicínského inženýrství a lékařské informatiky ČLS JEP, 2005. ISSN 1727-1983.
Rok: 2005

Pracoviště: Katedra elektromagnetického pole
Anotace:
Research of interactions between em field and biological systems is of growing interests elsewhere. Also here in czech republic there are several groups working in this field, often in international co-operations. We will describe here mainly basic technical equipment developed for 5 different research projects in the discussed area of interactions of em field and biological systems.

Technical Equipment for Research of EM Field and Biological Systems Interactions

Autoři: prof. Ing. Jan Vrba, CSc., Vannucci, L., Peschke, P., Vožeh, F., Vojtíšek, M., Kubeš, J., Herza, J., Cvek, J., Chovanec, R., Dřížďal, T., Zajíček, R., Pourová, M., Žák, O.
Publikace: The 13th Conference on Microwave Techniques - COMITE 2005. Praha: IEEE Czechoslovakia Section, 2005. pp. 215-218. ISBN 80-86582-16-7.
Rok: 2005

Pracoviště: Katedra elektromagnetického pole
Anotace:
Paper deals with description of technical equipment for research of interactions between EM field and biological systems. Main topics are microwave applicators for biological experiments - 4 projects in Czech republic and 1 project in Germany.

TEM Wave Applicators with Large Effective Aperture

Autoři: Herza, J., Chovanec, R., Cvek, J., prof. Ing. Jan Vrba, CSc.,
Publikace: Radioelektronika 2005 - Conference Proceedings. Brno: VUT v Brně, FEI, Ústav radioelektroniky, 2005. pp. 405-408. ISBN 80-214-2904-6.
Rok: 2005

Pracoviště: Katedra elektromagnetického pole
Anotace:
This contribution describes new types of applicators for microwave hyperthermia with large effective aperture, which are used for Head and Neck cancer treatment.

Theory of Evanescent Mode Applicators

Autoři: prof. Ing. Jan Vrba, CSc., Cvek, J., Ing. Ladislav Oppl, Ph.D., Kvěch, J., Kubeš, J.
Publikace: PIERS 2005. Cambridge, MA: The Electromagnetics Academy, 2005.
Rok: 2005

Pracoviště: Katedra elektromagnetického pole
Anotace:
Paper deals with theoretical basis of technology so called waveguide applicators with evanescent mode, which are used for cancer treatment.

Vlnovodný aplikátor pro vysoušení textilních materiálů

Autoři: Žák, O., prof. Ing. Jan Vrba, CSc.,
Publikace: Odborné semináře - Sborník za rok 2004/2005. Praha: Československá sekce IEEE, 2005. pp. 44-47. ISBN 80-86582-17-5.
Rok: 2005

Pracoviště: Katedra elektromagnetického pole
Anotace:
V tomto článku bych se chtěl zabývat problémy mikrovlnného vysoušení a návrhem sušičky textilu. Konkrétně se jedná o návrh jedné buňky vlnovodného aplikátoru. Uvádím zde teoretický model vlnovodného aplikátoru, výsledky numerického modelování v simulátoru elektromanetického pole a experimentální ověření. Návrh mikrovlnné sušárny je relizován ve volném pásmu na frekvenci 2,45 GHz.

Waveguide Applicator for Microwave Textile Drying

Autoři: Žák, O., prof. Ing. Jan Vrba, CSc.,
Publikace: Radioelektronika 2005 - Conference Proceedings. Brno: VUT v Brně, FEI, Ústav radioelektroniky, 2005. pp. 263-266. ISBN 80-214-2904-6.
Rok: 2005

Pracoviště: Katedra elektromagnetického pole
Anotace:
This paper deals with issues of microwave heating and the design of microwave textile dryer. In particular, the design of one cell (i.e. waveguide applicator) is dealt with. The design is realized in a free bandwidth at the frequency of 2.45 GHz.

Waveguide Applicators for Microwave Thermotherapy: Aperture and Water Bolus Resonances

Autoři: prof. Ing. Jan Vrba, CSc., Cvek, J., Herza, J., Chovanec, R., Ing. Ladislav Oppl, Ph.D.,
Publikace: The 3rd European Medical and Biological Engineering Conference - EMBEC´05. Praha: Společnost biomedicínského inženýrství a lékařské informatiky ČLS JEP, 2005. ISSN 1727-1983.
Rok: 2005

Pracoviště: Katedra elektromagnetického pole
Anotace:
Paper deals with our new results in the field of external local appliators used for microwave thermotherapy, like e.g. cancer treatment, physiotherapy, etc.

Waveguide Horn Applicator for Microwave Thermotherapy with Dielectric Lateral Faces

Autoři: Dřížďal, T., prof. Ing. Jan Vrba, CSc.,
Publikace: The 3rd European Medical and Biological Engineering Conference - EMBEC´05. Praha: Společnost biomedicínského inženýrství a lékařské informatiky ČLS JEP, 2005. ISSN 1727-1983.
Rok: 2005

Pracoviště: Katedra elektromagnetického pole
Anotace:
This paper describes the possibilities to use dielectric material as a lateral faces in waveguide-hor applicators. Two types of the applicator for local microwave thermotherapy are compared. At the parameters of the applicators (impedance matching, SAR distribution) are shown the advantages and disadvantages of the applicators with dielectric lateral faces.

Applicators for "BPH" Treatment: Theoretical Limits of the Effective Heating Depth

Autoři: prof. Ing. Jan Vrba, CSc., Hlaváč, R., Chovanec, R., Herza, J., Kvěch, J., Kubeš, J.
Publikace: 2004 URSI EMTS - Proceedings. Pisa: University of Pisa, 2004. pp. 501-503.
Rok: 2004

Pracoviště: Katedra elektromagnetického pole
Anotace:
Microwave thermotherapy (hyperthermia) is being used for cancer treatment in many countries around the world since early 80s. We describe our new technical results dealing with microwve thermotherapy in the cancer treatment and BPH prostate treatment, see ref. /1,2/. Our research is to develop intracavitary applicators for effective treatment.

Applicators for Deep Local Microwave Thermotherapy

Autoři: prof. Ing. Jan Vrba, CSc., Cvek, J., Chovanec, R., Herza, J., Ing. Ladislav Oppl, Ph.D., Trefná, H., Pavlas, J., Kvěch, J., Kubeš, J., Veselá, M.
Publikace: PIERS 2004 (Nanjing) Proceedings. Cambridge: Electromagnetics Academy, 2004. pp. 81. ISBN 0-9679674-4-9.
Rok: 2004

Pracoviště: Katedra elektromagnetického pole
Anotace:
Design and evaluation of waveguide applicators (working either above cut-off frequency or evanescent mode applicator working below waveguide cut-off) are being described in this paper. Theoretical models of the mentioned applicators and its SAR distribution, results of numerical modelling (software product SEMCAD) and experimetal evaluations are discussed.

Design of Waveguide Applicators for Microwave Thermotherapy by Aid of Numerical Methods

Autoři: Chovanec, R., prof. Ing. Jan Vrba, CSc.,
Publikace: Proceedings of SPIE: Microwave and Optical Technology 2003, Vol. 5445. Bellingham: SPIE, 2004. pp. 410-413. ISBN 0-8194-5368-4.
Rok: 2004

Pracoviště: Katedra elektromagnetického pole
Anotace:
This contribution outlines possibilities of the numerical method for the evaluation of electromagnetic field and the temperature distribution in front of the applicator's aperture. This modeling is useful for having basic idea about the distribution of the temperature inside the treated area.

Dielectric Properties of Selected Fruits and Vegetables Treated and Non-Treated by DIC

Autoři: Klíma, L., prof. Ing. Jan Vrba, CSc., Allaf, K., Sobolík, V.
Publikace: 16th International Congress of Chemical and Process Engineering. Praha: Process Engineering Publisher, Ing. Jan Novosad, 2004. pp. 1650. ISBN 80-86059-40-5.
Rok: 2004

Pracoviště: Katedra elektromagnetického pole
Anotace:
Paper deals with dielectric parameters with respect to temperature of the food components and products especially fruit and vegetables.

Hyperthermia Applicator Compatible with "MR"

Autoři: prof. Ing. Jan Vrba, CSc., Ing. Ladislav Oppl, Ph.D., Chovanec, R., Herza, J., Cvek, J., Trefná, H., Pavlas, J., Zuna, I., Peschke, P., Poušek, L.
Publikace: Conference Proceedings of Radioelektronika 2004. Bratislava: Slovak University of Technology, 2004. pp. 300-303. ISBN 80-227-2017-8.
Rok: 2004

Pracoviště: Katedra elektromagnetického pole
Anotace:
Temperature monitoring and control during microwave thermotherapy goes to non-invasive 3D thermometry system, e.g. either Magnetic Resonance (MR) or ultrasound (US). The goal of this paper is to describe design and experimental evaluation of a new type applicator for microwave thermotherapy, which will be compatible with MR.

Lékařské a průmyslové aplikace mikrovlnné techniky

Autoři: prof. Ing. Jan Vrba, CSc., Herza, J., Trefná, H., Cvek, J., Ing. Ladislav Oppl, Ph.D., Chovanec, R., Pourová, M.
Publikace: Sborník vzdělávacích a vědeckovýzkumných činností a nabídek. Praha: IEEE Czechoslovakia Section, 2004. pp. 34-35. ISBN 80-86582-15-9.
Rok: 2004

Pracoviště: Katedra elektromagnetického pole
Anotace:
Paper delas with general overview of prospectiv applications of microwaves in medecine (oncological clinical treatment etc.) and in industry (microwave drying, etc.).

Medical Applications of Microwaves

Autoři: prof. Ing. Jan Vrba, CSc.,
Publikace: ITSS 2004 - Summer School Proceedings. Brno: VUT v Brně, FEKT, Ústav radioelektroniky, 2004. p. 335-346.
Rok: 2004

Pracoviště: Katedra elektromagnetického pole
Anotace:
Paper deals with general overview of prospectives and future trends in the field of Medical Applications of Microwaves with special focus on Microwave Thermotherapy. Basic description of microwave applicators and theirs evaluation (both via SAR numerical simulations and via SAR measurements on special phantoms) is given

Medical Applicatons of Microwaves

Autoři: prof. Ing. Jan Vrba, CSc., Lapeš, M.
Publikace: Proceedings of SPIE: Microwave and Optical Technology 2003, Vol. 5445. Bellingham: SPIE, 2004. pp. 392-397. ISBN 0-8194-5368-4.
Rok: 2004

Pracoviště: Katedra elektromagnetického pole
Anotace:
Medical applications of microwaves are a quite new and a very rapidly developing field. Microwave thermotherapy is being used in medicine for the cancer treatment and treatment of some other diseases since early eighties. In this contribution we would like to offer general overview of present activities in the Czech Republic, i.e. clinical applications and results, technical aspects of thermo therapeutic equipment and last but not least, prospective diagnostics based on microwave principals ant technology and instrumentation.

Microwave Applicator for Animal Experiments

Autoři: prof. Ing. Jan Vrba, CSc., Chovanec, R., Ing. Ladislav Oppl, Ph.D., Herza, J., Cvek, J., Trefná, H., Zuna, I., Peschke, P.
Publikace: PIERS 2004 (Nanjing) Proceedings. Cambridge: Electromagnetics Academy, 2004. pp. 83. ISBN 0-9679674-4-9.
Rok: 2004

Pracoviště: Katedra elektromagnetického pole
Anotace:
The goal of the proposed paper is to describe design and experimental evaluation of a new type applicator for microwave thermotherapy, which will be compatible with MR. The first applicator of this type is just being used for a hyperthermia treatment of the experimentally induced pedicle tumors of the rat.

Microwave Applicators for "BMH" Thermotherapy

Autoři: prof. Ing. Jan Vrba, CSc., Hlaváč, R., Herza, J., Chovanec, R., Cvek, J., Ing. Ladislav Oppl, Ph.D.,
Publikace: Proceedings of SPIE: Microwave and Optical Technology 2003, Vol. 5445. Bellingham: SPIE, 2004. pp. 402-405. ISBN 0-8194-5368-4.
Rok: 2004

Pracoviště: Katedra elektromagnetického pole

Microwave Applicators for "BPH" Thermotherapy

Autoři: prof. Ing. Jan Vrba, CSc., Bolmsjo, M., Chovanec, R., Herza, J., Cvek, J., Ing. Ladislav Oppl, Ph.D., Kubeš, J., Kvěch, J.
Publikace: European Microwave Week 2004 - Conference Proceedings. 2004. pp. 1553-1556. ISBN 1-58053-994-7.
Rok: 2004

Pracoviště: Katedra elektromagnetického pole
Anotace:
Paper deals with new results in the field of intracavitary microwave applicators used for Benign Prostatic Hyperplasia (BPH) treatment. Costs and risks associated with clasical BPH treatment (TURP and open surgery) have promoted the development of minimally invasive methods. Microwave thermotherapy, varying forms of laser treatment, transurethral needle ablation, etc. have all been developed in the 1990s. The underlying principle behind these methods is to coagulate prostatic adenomatous tissue by means of heat. Of all the available minimal invasive treatment modalities, transurethral microwave is one of the most wide spread at present [1].

Microwave Applicators for "BPH" Thermotherapy

Autoři: prof. Ing. Jan Vrba, CSc., Bolmsjo, M., Hlaváč, R., Ing. Ladislav Oppl, Ph.D.,
Publikace: Advanced Engineering Design 2004. Praha: Orgit, 2004. ISBN 80-86059-41-3.
Rok: 2004

Pracoviště: Katedra elektromagnetického pole
Anotace:
Paper deals with new results in the field of intracavitary microwave applicators used for Benign Prostatic Hyperplasia (BHP) treatment.

Microwave Thermotherapy

Autoři: prof. Ing. Jan Vrba, CSc., Ing. Ladislav Oppl, Ph.D., Kvěch, J., Kubeš, J., Herza, J., Chovanec, R., Trefná, H., Pavlas, J., Cvek, J.
Publikace: Conference Proceedings of Radioelektronika 2004. Bratislava: Slovak University of Technology, 2004. pp. 496-499. ISBN 80-227-2017-8.
Rok: 2004

Pracoviště: Katedra elektromagnetického pole
Anotace:
In this paper we would like to outline new trends in microwave thermotherapy, both clinical and technical. In details we want here describe the field of intracavitary treatment with major applicatations in urology, the so called BPH treatment. New trends we can divide into two major groups: clinical trends, technical trends.

Microwave Thermotherapy: Technical Aspects

Autoři: prof. Ing. Jan Vrba, CSc., Ing. Ladislav Oppl, Ph.D., Cvek, J., Kvěch, J., Kubeš, J.
Publikace: 2004 URSI EMTS - Proceedings. Pisa: University of Pisa, 2004. pp. 492-494.
Rok: 2004

Pracoviště: Katedra elektromagnetického pole
Anotace:
The goal of this paper is to describe design and experimental evaluation of a new type applicator for microwave thermotherapy, which will be compatible with NMR. The first applicator of this type is just being used for a hyperthermia treatment of the experimentally induced pedicle tumours of the rat.

Numerical Simulation of Microwave Heating in DIC Reactor

Autoři: Klima, J., prof. Ing. Jan Vrba, CSc., Žitný, R., Allaf, K., Sobolík, V.
Publikace: 16th International Congress of Chemical and Process Engineering. Praha: Process Engineering Publisher, Ing. Jan Novosad, 2004. pp. 1308. ISBN 80-86059-40-5.
Rok: 2004

Pracoviště: Katedra elektromagnetického pole
Anotace:
Paper deals with the research of microwaves for food industry. Experimental system for microwave extraction has been build and evaluated both by numerical simulations and by measurements.

Postavení hypertermie v radikální léčbě karcinomů ORL oblasti

Autoři: Kubeš, J., Kvěch, J., Cvek, J., prof. Ing. Jan Vrba, CSc., Pála, M.
Publikace: Radiační onkologie 2004. Hradec Králové: Klinika onkologie a radioterapie, Fakultní nemocnice, 2004. pp. 64-65. ISBN 80-239-2107-X.
Rok: 2004

Pracoviště: Katedra elektromagnetického pole
Anotace:
Tento příspěvek je zaměřen na zlepšení léčby nádorů ORL oblasti přidáním hypertermie ke standardní radioterapii. Výsledky léčby 26 pacientů lv roce 2003 kombinovanou metodou jsou připojeny.

Regional Applicator at the frequency 70 MHz

Autoři: Herza, J., prof. Ing. Jan Vrba, CSc.,
Publikace: Proceedings of SPIE: Microwave and Optical Technology 2003, Vol. 5445. Bellingham: SPIE, 2004. pp. 418-421. ISBN 0-8194-5368-4.
Rok: 2004

Pracoviště: Katedra elektromagnetického pole
Anotace:
This paper is focused on the design, the construction and the evaluation of the resonant loop, which can be used as a part of the regional microwave applicator for medical application (microwave thermotherapy).

Thermotherapeutic Waveguide Applicator for Cancer Treatment

Autoři: Cvek, J., prof. Ing. Jan Vrba, CSc.,
Publikace: Proceedings of SPIE: Microwave and Optical Technology 2003, Vol. 5445. Bellingham: SPIE, 2004. pp. 406-409. ISBN 0-8194-5368-4.
Rok: 2004

Pracoviště: Katedra elektromagnetického pole
Anotace:
Thermotherapy is the one of standart methods of the complex cancer treatment. In many studies, the improvement in local tumor control and free life survival has been shown. Goal of this project was realization of Evanescent Mode Waveguide Applicator and its comparison with Waveguide Applicator, which is clinically used. The optimization of the Evanescent Mode Applicator has been studied with aid of numerical methods (FDTD).

Wavequide Applicators for Deep Local Treatment of Cancer

Autoři: prof. Ing. Jan Vrba, CSc., Cvek, J., Chovanec, R., Herza, J., Ing. Ladislav Oppl, Ph.D., Kvěch, J., Kubeš, J., Veselá, M.
Publikace: Advanced Engineering Design 2004. Praha: Orgit, 2004. ISBN 80-86059-41-3.
Rok: 2004

Pracoviště: Katedra elektromagnetického pole
Anotace:
Paper deals with design criteria for waveguide applicators for deep local microwave thermotherapy. Numerical simulations and experimental evaluations are described.

Applicators for Microwave Thermotherapy

Autoři: prof. Ing. Jan Vrba, CSc., Chovanec, R., Cvek, J., Herza, J., Ing. Ladislav Oppl, Ph.D.,
Publikace: EMF 2003. Liege: A.I.M, 2003. pp. 175-178.
Rok: 2003

Pracoviště: Katedra elektromagnetického pole
Anotace:
Paper deals with our new results in the field of waveguide and intracavitary applicators used for microwave thermotherapy, like e.g. cancer treatment, phasiotherapy, benign prostatic hyperplasia (BPH) treatment, etc.

Evaluation of Microwave Applicators for Microwave Thermotherapy

Autoři: Herza, J., prof. Ing. Jan Vrba, CSc., Cvek, J., Chovanec, R.
Publikace: 13th International Travelling Summer School on Microwaves & Lightwaves 2003. Darmstadt: Institute of Microwave Engineering - University of Technology, 2003. pp. 255-256.
Rok: 2003

Pracoviště: Katedra elektromagnetického pole
Anotace:
This paper is focused on the evaluation of microwave applicators for the microwave thermotherapy. For this evaluation we use water phantom of the biologicall tissue and we measure E-field distribution in this phantom.

Evanescent Waveguide Applicator for Microwave Thermotherapy in Oncology

Autoři: Cvek, J., prof. Ing. Jan Vrba, CSc.,
Publikace: COMITE 2003. Praha: IEEE Czechoslovakia Section, 2003. pp. 37-40. ISBN 80-86582-09-4.
Rok: 2003

Pracoviště: Katedra elektromagnetického pole
Anotace:
Thermotherapy is the one of the methods of complex cancer treatment. Goal of this project was realization of Evanescent Mode Waveguide Applicator and its comparison with Waveguide Applicator, which is clinically used. The optimization of the Evanescent Mode Applicator was realized by appropriate configuration of the resonant circuit.

Hypertermie - standardní modalita komplexní protinádorové léčby

Autoři: Kubeš, J., Cvek, J., Ing. Ladislav Oppl, Ph.D., Kvěch, J., Veselá, M., prof. Ing. Jan Vrba, CSc.,
Publikace: Radiační onkologie. 2003, 3(2), 11-15. ISSN 1213-1695.
Rok: 2003

Pracoviště: Katedra elektromagnetického pole
Anotace:
V tomto příspěvku je shrnut historický vývoj hypertermické léčby nádorových onemocnění ve světě i u nás. Jsou zmíněny mechanismy účinku HT na makroskopické, molekulárně biologické i imunologické úrovni. Je popsáno stávající technické vybavení spolu s výhledem do budoucna. Přiložen je přehled klinických studií, kde se jednoznačně prokázal pozitivní efekt HT při léčbě onkologických pacientů.

Inovace výuky mikrovlnné techniky - předměty "Úvod do mikrovlnné techniky" a "Lékařské aplikace mikrovlnné techniky"

Autoři: prof. Ing. Jan Vrba, CSc.,
Publikace: COMITE 2003 - Vzdělávací fórum. Praha: IEEE Czechoslovakia Section, 2003. pp. 26-28. ISBN 80-86582-11-6.
Rok: 2003

Pracoviště: Katedra elektromagnetického pole
Anotace:
Přednáška infromuje posluchače o inovacích přednášek, seminářů a laboratorní výuky předmětů : "Uvod do mikrovlnné techniky" a "Lékařské aplikace mikrovlnné techniky".

Lékařské aplikace interakcí biologické tkáně s elektromagnetickým polem

Autoři: prof. Ing. Jan Vrba, CSc., Ing. Ladislav Oppl, Ph.D., Chovanec, R., Herza, J., Cvek, J.
Publikace: COMITE 2003 - Grantové fórum. Praha: IEEE Czechoslovakia Section, 2003. pp. 24-25. ISBN 80-86582-10-8.
Rok: 2003

Pracoviště: Katedra elektromagnetického pole
Anotace:
Příspěvek je zaměřen na otázky lékařských aplikací interakce biologické tkáně s elektromagnetickým polem, zejména pak na využití při léčbě nádorových onemocnění.

Medical Applications of Microwaves

Autoři: prof. Ing. Jan Vrba, CSc., Lapeš, M.
Publikace: ISMOT 2003 - Book of Abstracts. Ostrava: VŠB, 2003. pp. 27. ISBN 80-248-0355-0.
Rok: 2003

Pracoviště: Katedra elektromagnetického pole
Anotace:
Microwave thermotherapy is being used in medicine for the cancer treatment and treatment of some other diseases since early eighties. In this contribution we would like to offer general overview of present activities in the Czech Republic, i.e. clinical applications and results, technical aspects of thermo therapeutic equipment and last but not least, prospective diagnostics based on microwave principals ant technology and instrumentation.

Medical Applications of Microwaves

Autoři: prof. Ing. Jan Vrba, CSc., Kvěch, J., Petruželka, L., Lapeš, M.
Publikace: COMITE 2003. Praha: IEEE Czechoslovakia Section, 2003. p. 1-7. ISBN 80-86582-09-4.
Rok: 2003

Pracoviště: Katedra elektromagnetického pole
Anotace:
Medical applications of microwaves are a quite new and a very rapidly developing field. Microwave thermotherapy is beind used in medicine for the cancer treatment and treatment of some other diseasessince early eighties. In this contribution we would like to offer general overview of present activities in the Czech Republic.

Microwave Thermotherapy in Czech Republic

Autoři: prof. Ing. Jan Vrba, CSc., Lapeš, M., Ing. Ladislav Oppl, Ph.D., Kvěch, J., Petruželka, L.
Publikace: AED 2003. Praha: Procesní inženýrství Ing. J. Novosad, 2003. pp. 202. ISBN 80-86059-35-9.
Rok: 2003

Pracoviště: Katedra elektromagnetického pole
Anotace:
We would like to describe our new technical results dealing with microwave thermotherapy in the cancer treatment. Our research interest is to develop applicators for deep local heating and for intracavitary cancer treatment as well. Special interest is given to the case of BPH prostate treatment. Basic evaluation of clinical results is presented.

Návrh a vývoj aplikátorů pro lékařské a průmyslové účely

Autoři: prof. Ing. Jan Vrba, CSc., Ing. Ladislav Oppl, Ph.D.,
Publikace: Sborník vzdělávacích a vědeckovýzkumných činností a nabídek katedry elektromagnetického pole FEL ČVUT. Praha: Československá sekce IEEE, 2003. pp. 44-45. ISBN 80-86582-13-2.
Rok: 2003

Pracoviště: Katedra elektromagnetického pole
Anotace:
Článek se zabývá vývojem v oblasti aplikací mikrovlnné techniky v medicíně a průmyslu - nástroji pro efektivná ohřev a vysoušení.

Numerical Methods in Microwave Thermotherapy

Autoři: Chovanec, R., prof. Ing. Jan Vrba, CSc.,
Publikace: COMITE 2003. Praha: IEEE Czechoslovakia Section, 2003. pp. 43-44. ISBN 80-86582-09-4.
Rok: 2003

Pracoviště: Katedra elektromagnetického pole
Anotace:
This contribution outlines possibilities of the numerical method for the evaluation of electromagnetic field and SAR distribution in front of the applicator aperture.

Regional Applicator for Microwave Thermotherapy

Autoři: Herza, J., prof. Ing. Jan Vrba, CSc.,
Publikace: COMITE 2003. Praha: IEEE Czechoslovakia Section, 2003. pp. 41-42. ISBN 80-86582-09-4.
Rok: 2003

Pracoviště: Katedra elektromagnetického pole
Anotace:
This paper is focused on the design and properities of the regional applicator for the microwave thermotherapy (at the frequency 70 MHz).

Termoterapeutické aplikátory v onkologii

Autoři: Cvek, J., prof. Ing. Jan Vrba, CSc.,
Publikace: COMITE 2003 - Grantové fórum. Praha: IEEE Czechoslovakia Section, 2003. pp. 7-8. ISBN 80-86582-10-8.
Rok: 2003

Pracoviště: Katedra elektromagnetického pole
Anotace:
Mikrovlnná termoterapie je relativně nová metoda pro léčbu onkologických pacientů. Cílem tohoto projektu je návrh a realizace aplikátorů spolu s jejich optimalizací a testováním. Optimalizovány jsou pro v současné době léčené lokality, kde se v randomizovaných studiích prokázala lepší lokální kontrolu i přežívání pacientů. Pro návrh aplikátorů se vycházelo z teorie evanescentních vlnovodů. S pomocí FDTD modelu byla studována možnost použití vodního bolusu pro eliminaci výskytu horkých míst. Byl navržen regionální aplikátor pro frekvenci 70 MHz s aperturou 35x20 cm. Pro léze na hrudní stěně byl navržen aplikátor (f = 434 Mhz, 35x12 cm) s možností změny delší strany aplikátoru.

Treatment Planning in Microwave Thermotherapy

Autoři: Chovanec, R., prof. Ing. Jan Vrba, CSc., Ing. Ladislav Oppl, Ph.D., Herza, J., Cvek, J.
Publikace: AED 2003. Praha: Procesní inženýrství Ing. J. Novosad, 2003. pp. 204. ISBN 80-86059-35-9.
Rok: 2003

Pracoviště: Katedra elektromagnetického pole
Anotace:
Our work is focused on the design, optimisation and experimental evaluation of the microwave applicators. This means to design a microwave structure capable above all: - to transfer efficiently the electromagnetic energy into the biological tissue, - to create the required 3D temperature distribution in the area to be treated.

Electromagnetic Hyperthermia of Malignancies

Autoři: prof. Ing. Jan Vrba, CSc., Lapeš, M.
Publikace: Endogenous Physical Fields in Biology. Praha: AV ČR, Ústav radiotechniky a elektroniky, 2002. pp. 31. ISBN 80-86269-08-6.
Rok: 2002

Pracoviště: Katedra elektromagnetického pole

Experiences on Microwave Hyperthermia in Clivical Practice

Autoři: Kvěch, J., Ing. Ladislav Oppl, Ph.D., prof. Ing. Jan Vrba, CSc., Kubeš, J.
Publikace: 21st Annual ESTRO Meeting. Brussels: Elsevier Science, 2002. pp. 223. ISSN 0167-8140.
Rok: 2002

Pracoviště: Katedra elektromagnetického pole

Hyperthermia Applicator Compatible with "MR"

Autoři: prof. Ing. Jan Vrba, CSc., Saliba, G., Ing. Ladislav Oppl, Ph.D., Chovanec, R., Zuna, I., Peschke, P., Poušek, L., Novák, P.
Publikace: XXVIIth General Assembly the International Union of Radio Science. Maastricht: URSI, 2002.
Rok: 2002

Pracoviště: Katedra elektromagnetického pole

Hyperthermia Applicator Compatible with "MR"

Autoři: prof. Ing. Jan Vrba, CSc., Saliba, G., Ing. Ladislav Oppl, Ph.D., Chovanec, R., Zuna, I., Peschke, P.
Publikace: IFMBE Proceedings. Wien: Technische Universität, 2002. pp. 736-739. ISSN 1680-0737. ISBN 3-901351-62-0.
Rok: 2002

Pracoviště: Katedra elektromagnetického pole

Hyperthermia Applicator Compatible with "MR"

Autoři: prof. Ing. Jan Vrba, CSc., Saliba, G., Ing. Ladislav Oppl, Ph.D., Chovanec, R., Zuna, I., Peschke, P.
Publikace: IFMBE Proceedings. Wien: Technische Universität, 2002. pp. 736-737. ISSN 1680-0737. ISBN 3-901351-62-0.
Rok: 2002

Pracoviště: Katedra elektromagnetického pole

Hyperthermia Applicator Compatible with Non-Invasive Thermometry System

Autoři: prof. Ing. Jan Vrba, CSc., Zuna, I., Peschke, P., Pousek, L., Lapes, M., Saliba, G., Ing. Ladislav Oppl, Ph.D., Novák, P.
Publikace: PIERS 2002 - Progress In Electromagnetics Research Symposium - Proceedings. Cambridge: Electromagnetics Academy, 2002. pp. 781. ISBN 0-9679674-2-2.
Rok: 2002

Pracoviště: Katedra elektromagnetického pole

Inovace předmětu: "Lékařské aplikace mikrovlnné techniky"

Autoři: prof. Ing. Jan Vrba, CSc.,
Publikace: WORKSHOP - Vzdělávací fórum - nabídka aktivit. Praha: ČVUT FEL, Katedra elektromagnetického pole, 2002. pp. 19. ISBN 80-86582-07-8.
Rok: 2002

Pracoviště: Katedra elektromagnetického pole

Interactions of Biological Tissue with Electromagnetic Field

Autoři: prof. Ing. Jan Vrba, CSc., Vokurka, J., Ing. Ladislav Oppl, Ph.D., Chovanec, R., Cvek, J., Herza, J., Kunstát, P.
Publikace: WORKSHOP - Grantové fórum. Praha: ČVUT FEL, Katedra elektromagnetického pole, 2002. pp. 86-88. ISBN 80-86582-06-X.
Rok: 2002

Pracoviště: Katedra elektromagnetického pole

LED Probes for Evaluation of Microwave Applicators

Autoři: prof. Ing. Jan Vrba, CSc., Herza, J., Ing. Ladislav Oppl, Ph.D., Kvěch, J., Lapeš, M.
Publikace: ESHO. Bergen: Norweign Cancer Society, 2002.
Rok: 2002

Pracoviště: Katedra elektromagnetického pole

Microwave Thermotherapy for Cancer Treatment and Other Medical Applications

Autoři: prof. Ing. Jan Vrba, CSc., Ing. Ladislav Oppl, Ph.D., Chovanec, R., Herza, J., Cvek, J., Kunstát, P., Kvěch, J., Kubeš, J., Veselá, M.
Publikace: WORKSHOP - Grantové fórum. Praha: ČVUT FEL, Katedra elektromagnetického pole, 2002. pp. 89-92. ISBN 80-86582-06-X.
Rok: 2002

Pracoviště: Katedra elektromagnetického pole

Microwave Thermotherapy in Czech Republic

Autoři: prof. Ing. Jan Vrba, CSc., Lapeš, M., Ing. Ladislav Oppl, Ph.D., Kvěch, J., Petruželka, L.
Publikace: XXVIIth General Assembly the International Union of Radio Science. Maastricht: URSI, 2002.
Rok: 2002

Pracoviště: Katedra elektromagnetického pole

Microwave Thermotherapy in Czech Republic - Technical and Clinical Aspects

Autoři: prof. Ing. Jan Vrba, CSc., Lapes, M., Ing. Ladislav Oppl, Ph.D., Kvech, J., Petruzelka, L.
Publikace: PIERS 2002 - Progress In Electromagnetics Research Symposium - Proceedings. Cambridge: Electromagnetics Academy, 2002. pp. 782. ISBN 0-9679674-2-2.
Rok: 2002

Pracoviště: Katedra elektromagnetického pole

Microwave Thermotherapy: Near Future Trends

Autoři: prof. Ing. Jan Vrba, CSc., Lapeš, M., Peschke, P., Zuna, I., Ing. Ladislav Oppl, Ph.D., Kvěch, J., Kubeš, J.
Publikace: IFMBE Proceedings. Wien: Technische Universität, 2002. pp. 738-739. ISSN 1680-0737. ISBN 3-901351-62-0.
Rok: 2002

Pracoviště: Katedra elektromagnetického pole

Microwave Waveguide Applicators

Autoři: Cvek, J., prof. Ing. Jan Vrba, CSc., Ing. Ladislav Oppl, Ph.D.,
Publikace: Endogenous Physical Fields in Biology. Praha: AV ČR, Ústav radiotechniky a elektroniky, 2002. pp. 82-83. ISBN 80-86269-08-6.
Rok: 2002

Pracoviště: Katedra elektromagnetického pole

Microwave Waveguide Applicators

Autoři: prof. Ing. Jan Vrba, CSc., Cvek, J., Ing. Ladislav Oppl, Ph.D.,
Publikace: ESHO. Bergen: Norweign Cancer Society, 2002,
Rok: 2002

Pracoviště: Katedra elektromagnetického pole

Návrh a vývoj aplikátorů pro lékařské a průmyslové účely

Autoři: prof. Ing. Jan Vrba, CSc., Ing. Ladislav Oppl, Ph.D.,
Publikace: WORKSHOP - Vzdělávací fórum - nabídka aktivit. Praha: ČVUT FEL, Katedra elektromagnetického pole, 2002. pp. 57-58. ISBN 80-86582-07-8.
Rok: 2002

Pracoviště: Katedra elektromagnetického pole

Návrh a vývoj aplikátorů pro průmyslové účely

Autoři: prof. Ing. Jan Vrba, CSc., Ing. Ladislav Oppl, Ph.D.,
Publikace: WORKSHOP - Grantové fórum. Praha: ČVUT FEL, Katedra elektromagnetického pole, 2002. pp. 93-95. ISBN 80-86582-06-X.
Rok: 2002

Pracoviště: Katedra elektromagnetického pole

Probes for Evaluation of Microwave Applicators

Autoři: Herza, J., prof. Ing. Jan Vrba, CSc.,
Publikace: Endogenous Physical Fields in Biology. Praha: AV ČR, Ústav radiotechniky a elektroniky, 2002. pp. 80-81. ISBN 80-86269-08-6.
Rok: 2002

Pracoviště: Katedra elektromagnetického pole

Zpracování medicínského obrazu

Autoři: prof. Ing. Jan Vrba, CSc.,
Publikace: WORKSHOP - Vzdělávací fórum - nabídka aktivit. Praha: ČVUT FEL, Katedra elektromagnetického pole, 2002. pp. 59-60. ISBN 80-86582-07-8.
Rok: 2002

Pracoviště: Katedra elektromagnetického pole

Behaviour of Hyperthermia Waveguide Applicators Near to the CUT-OFF Frequency

Autoři: prof. Ing. Jan Vrba, CSc., Franconi, C., Lapeš, M.
Publikace: ESHO 2001 - Abstracts Book. Verona: Policlinico G.B. Rossi, 2001. pp. 42-43.
Rok: 2001

Pracoviště: Katedra elektromagnetického pole

Experiences on Microwave Hyperthermia in Clinical Practice

Autoři: Ing. Ladislav Oppl, Ph.D., Kvěch, J., prof. Ing. Jan Vrba, CSc.,
Publikace: COMITE 2001. Praha: IEEE Czechoslovakia Section, 2001. pp. 207-210. ISBN 80-902417-9-4.
Rok: 2001

Pracoviště: Katedra elektromagnetického pole

Experimental Equipment for Hyperthermia Control and Ultrasound Temperature Monitoring

Autoři: Schreib, P., Novák, P., Volhejn, P., Schreib, P., prof. Ing. Jan Vrba, CSc., Poušek, L., Zuna, I.
Publikace: ESHO 2001 - Abstracts Book. Verona: Policlinico G.B. Rossi, 2001. pp. 104-105.
Rok: 2001

Pracoviště: Katedra elektromagnetického pole

Experimental Technical Device for Precise Texture Characteristics Evaluation of Malign Tumors of Animal Models

Autoři: Novák, P., Poušek, L., Volhejn, P., prof. Ing. Jan Vrba, CSc.,
Publikace: Proceedings of Workshop 2001. Praha: České vysoké učení technické v Praze, 2001. pp. 760-761. ISBN 80-01-02335-4.
Rok: 2001

Pracoviště: Katedra elektromagnetického pole

Hyperthermia Applicator Compatible with "NMR"

Autoři: prof. Ing. Jan Vrba, CSc., Saliba, G., Ing. Ladislav Oppl, Ph.D., Chovanec, R., Zuna, I., Peschke, P., Poušek, L., Novák, P.
Publikace: Conference Proceedings - 31st EuMC 2001. London: CMP Europe Ltd, 2001. pp. 297-300. ISBN 08-62-13148-0.
Rok: 2001

Pracoviště: Katedra elektromagnetického pole

Hyperthermia Applicator Compatible with "NMT"

Autoři: prof. Ing. Jan Vrba, CSc., Saliba, G., Ing. Ladislav Oppl, Ph.D., Chovanec, R., Zuna, I., Peschke, P.
Publikace: Biologické systémy a elektromagnetické pole. Praha: ČVUT FEL, Katedra elektromagnetického pole, 2001. pp. 45-47. ISBN 80-01-02389-3.
Rok: 2001

Pracoviště: Katedra elektromagnetického pole

Hyperthermia Applicator Compatible with Non-Invasive Thermometry System

Autoři: prof. Ing. Jan Vrba, CSc., Peschke, P., Poušek, L., Lapeš, M., Saliba, G., Zuna, I., Ing. Ladislav Oppl, Ph.D., Novák, P.
Publikace: COMITE 2001. Praha: IEEE Czechoslovakia Section, 2001. pp. 215-217. ISBN 80-902417-9-4.
Rok: 2001

Pracoviště: Katedra elektromagnetického pole

Microwave Hyperthermia Applicator Compatible with Non-Invasive Thermometry System

Autoři: prof. Ing. Jan Vrba, CSc., Zuna, I., Peschke, P., Poušek, L., Lapeš, M., Saliba, G., Ing. Ladislav Oppl, Ph.D., Novák, P.
Publikace: ESHO 2001 - Abstracts Book. Verona: Policlinico G.B. Rossi, 2001. pp. 81-83.
Rok: 2001

Pracoviště: Katedra elektromagnetického pole

Microwave Thermotherapy: Near Future Trends

Autoři: prof. Ing. Jan Vrba, CSc., Lapeš, M., Peschke, P., Zuna, I., Ing. Ladislav Oppl, Ph.D., Chovanec, R.
Publikace: COMITE 2001. Praha: IEEE Czechoslovakia Section, 2001, pp. 101-104. ISBN 80-902417-9-4.
Rok: 2001

Pracoviště: Katedra elektromagnetického pole

New Trends in Microwave Thermotherapy

Autoři: prof. Ing. Jan Vrba, CSc., Bolmsjo, M., Lapeš, M., Ing. Ladislav Oppl, Ph.D., Hlaváč, R., Chovanec, R., Novák, P.
Publikace: Biologické systémy a elektromagnetické pole. Praha: ČVUT FEL, Katedra elektromagnetického pole, 2001. pp. 48. ISBN 80-01-02389-3.
Rok: 2001

Pracoviště: Katedra elektromagnetického pole

New Trends in Microwave Thermotherapy

Autoři: prof. Ing. Jan Vrba, CSc., Bolmsjo, M., Lapeš, M., Peschke, P., Zuna, I., Voleš, O., Ing. Ladislav Oppl, Ph.D., Saliba, G.
Publikace: Radioelektronika 2001 - Conference Proceedings. Brno: VUT v Brně, FEI, Ústav radioelektroniky, 2001, pp. 98-100. ISBN 80-214-1861-3.
Rok: 2001

Pracoviště: Katedra elektromagnetického pole

New Trends in Microwave Thermotherapy

Autoři: prof. Ing. Jan Vrba, CSc., Lapeš, M., Voleš, O., Ing. Ladislav Oppl, Ph.D., Saliba, G., Smítka, J., Klouda, J.
Publikace: Proceedings of Workshop 2001. Praha: České vysoké učení technické v Praze, 2001. pp. 822. ISBN 80-01-02335-4.
Rok: 2001

Pracoviště: Katedra elektromagnetického pole

New Ultrasonic Approach to the Noninvasive Temperature Monitoring for Microwave Thermotherapy

Autoři: Novák, P., Poušek, L., Schreib, P., prof. Ing. Jan Vrba, CSc., Zuna, I.
Publikace: Ultraschall in der Medizin. Stuttgart: Georg Thieme Verlag, 2001, pp. 109-111.
Rok: 2001

Pracoviště: Katedra elektromagnetického pole

New Ultrasonic Approach to the Noninvasive Temperature Monitoring for Microwave Thermotherapy

Autoři: Novák, P., Poušek, L., Schreib, P., prof. Ing. Jan Vrba, CSc., Zuna, I.
Publikace: Poster 2001. Praha: České vysoké učení technické v Praze, Fakulta elektrotechnická, 2001. pp. NS30.
Rok: 2001

Pracoviště: Katedra elektromagnetického pole

Noninvasive Ultrasonic Temperature Estimation During Microwave Thermotherapy

Autoři: Novák, P., Poušek, L., prof. Ing. Jan Vrba, CSc., Zuna, I.
Publikace: COMITE 2001. Praha: IEEE Czechoslovakia Section, 2001. pp. 105-108. ISBN 80-902417-9-4.
Rok: 2001

Pracoviště: Katedra elektromagnetického pole

SAR of Hyperthermia Waveguide Applicators

Autoři: prof. Ing. Jan Vrba, CSc., Franconi, C., Lapeš, M., Ing. Ladislav Oppl, Ph.D., Chovanec, R.
Publikace: COMITE 2001. Praha: IEEE Czechoslovakia Section, 2001. pp. 219-220. ISBN 80-902417-9-4.
Rok: 2001

Pracoviště: Katedra elektromagnetického pole

Transdisciplinary Research in Biomedical Engineering: Microwave Thermotherapy

Autoři: prof. Ing. Jan Vrba, CSc., Ing. Ladislav Oppl, Ph.D., Novák, P., Saliba, G., Chovanec, R.
Publikace: COMITE 2001 - Grant Forum. Praha: Československá sekce IEEE, 2001. pp. 11-12. ISBN 80-86582-02-7.
Rok: 2001

Pracoviště: Katedra elektromagnetického pole

Ultrasonic Approach to Noninvasive Temperature Monitoring during Microwave Thermotherapy

Autoři: Novák, P., Zuna, I., Poušek, L., prof. Ing. Jan Vrba, CSc.,
Publikace: Radioengineering. 2001, 10(2), 32-37. ISSN 1210-2512.
Rok: 2001

Pracoviště: Katedra elektromagnetického pole

Variations in Skin Blood Perfusion Using Intrated and Microwave Application Measured by a Simple Fiber Optical Sensor System

Autoři: Blažek, V., prof. Ing. Jan Vrba, CSc.,
Publikace: Biologické systémy a elektromagnetické pole. Praha: ČVUT FEL, Katedra elektromagnetického pole, 2001. pp. 4-7. ISBN 80-01-02389-3.
Rok: 2001

Pracoviště: Katedra elektromagnetického pole

Waveguide Hyperthermia Applicators: "SAR" Analysis

Autoři: prof. Ing. Jan Vrba, CSc., Ing. Ladislav Oppl, Ph.D., Chovanec, R., Voleš, O., Saliba, G., Lapeš, M.
Publikace: Biologické systémy a elektromagnetické pole. Praha: ČVUT FEL, Katedra elektromagnetického pole, 2001. pp. 49-50. ISBN 80-01-02389-3.
Rok: 2001

Pracoviště: Katedra elektromagnetického pole

"NMR" Compatibility of Microwave Hyperthermia Applicators

Autoři: prof. Ing. Jan Vrba, CSc., Zuna, I., Peschke, P., Schad, L., Lapeš, M., Ing. Ladislav Oppl, Ph.D., Novák, P.
Publikace: U.R.S.I. - Electromagnetic Aspects of Selforganization in Biology. Praha: AV ČR, Ústav radiotechniky a elektroniky, 2000. pp. 65. ISBN 80-86269-04-3.
Rok: 2000

Pracoviště: Katedra elektromagnetického pole

Analyses of Intracavitary Thermotherapy

Autoři: prof. Ing. Jan Vrba, CSc., Lapeš, M., Ing. Ladislav Oppl, Ph.D., Saliba, G.
Publikace: Biologické systémy a elektromagnetické pole. Praha: ČVUT FEL, Katedra elektromagnetického pole, 2000. pp. 41. ISBN 80-01-02185-8.
Rok: 2000

Pracoviště: Katedra elektromagnetického pole

Bestimmung der Temperaturverteilung im erhitzen Tumorgewebe durch Segmentation von Ultraschallbildern

Autoři: Novák, P., Zuna, I., Poušek, L., Peschke, P., Lorenz, A., Schreib, P., prof. Ing. Jan Vrba, CSc., Debus, J.
Publikace: Ultraschall in der Medizin. Stuttgart: Georg Thieme Verlag, 2000. pp. 195-197. ISSN 1439-0914.
Rok: 2000

Pracoviště: Katedra elektromagnetického pole

Future Trends in Microwave Thermotherapy

Autoři: prof. Ing. Jan Vrba, CSc., Lapeš, M., Blažek, V., Ing. Ladislav Oppl, Ph.D., Saliba, G.
Publikace: Biologické systémy a elektromagnetické pole. Praha: ČVUT FEL, Katedra elektromagnetického pole, 2000. pp. 40. ISBN 80-01-02185-8.
Rok: 2000

Pracoviště: Katedra elektromagnetického pole

Microwave Application for "BPH" Thermotherapy

Autoři: prof. Ing. Jan Vrba, CSc., Bolmsjo, M., Lapeš, M., Ing. Ladislav Oppl, Ph.D.,
Publikace: European Microwave Conference. Brussels: The European Microwave Association 2000, 2000. pp. 320-323. ISBN 0-86213-212-6.
Rok: 2000

Pracoviště: Katedra elektromagnetického pole

Microwave Applicators for BPH Thermotherapy

Autoři: prof. Ing. Jan Vrba, CSc., Lapeš, M., Domeš, J., Ing. Ladislav Oppl, Ph.D., Saliba, G.
Publikace: U.R.S.I. - Electromagnetic Aspects of Selforganization in Biology. Praha: AV ČR, Ústav radiotechniky a elektroniky, 2000. pp. 66. ISBN 80-86269-04-3.
Rok: 2000

Pracoviště: Katedra elektromagnetického pole

New Trends in Medical Applications of Microwaves

Autoři: prof. Ing. Jan Vrba, CSc., Lapeš, M., Zuna, I., Peschke, P., Poušek, L., Rovenský, P., Sula, J., Novák, P.
Publikace: U.R.S.I. - Electromagnetic Aspects of Selforganization in Biology. Praha: AV ČR, Ústav radiotechniky a elektroniky, 2000. pp. 68. ISBN 80-86269-04-3.
Rok: 2000

Pracoviště: Katedra elektromagnetického pole

Noninvasive Temperature Monitoring in the High-Frequency Heated Rat Pedicle Tumors Using Ultrasound Tissue Characterization Method

Autoři: Poušek, L., Novák, P., Zuna, I., prof. Ing. Jan Vrba, CSc., Peschke, P., Schreib, P.
Publikace: Proceedings of Workshop 2000. Praha: České vysoké učení technické v Praze, 2000. pp. 538. ISBN 80-01-02229-3.
Rok: 2000

Pracoviště: Katedra elektromagnetického pole

Ultrasound - Prospective Kind of Noninvasive Temperature Monitoring During Microwave Thermotherapy Treatment

Autoři: Novák, P., Zuna, I., Poušek, L., prof. Ing. Jan Vrba, CSc., Schreib, P.
Publikace: U.R.S.I. - Electromagnetic Aspects of Selforganization in Biology. Praha: AV ČR, Ústav radiotechniky a elektroniky, 2000, pp. 67. ISBN 80-86269-04-3.
Rok: 2000

Pracoviště: Katedra elektromagnetického pole

"SAR" Distribution in the Biological Tissue Treated by Microwave Thermotherapy

Autoři: prof. Ing. Jan Vrba, CSc., Blažek, V., Lapeš, M., Ing. Ladislav Oppl, Ph.D., Rovenský, P.
Publikace: Biologické systémy a elektromagnetické pole. Praha: ČVUT FEL, Katedra elektromagnetického pole, 1999. pp. 43-47. ISBN 80-01-01997-7.
Rok: 1999

Pracoviště: Katedra elektromagnetického pole

Applicator for Animal Treatment by Microwave Thermotherapy

Autoři: prof. Ing. Jan Vrba, CSc., Zuna, I., Peschke, P., Schad, L., Poušek, L., Ing. Ladislav Oppl, Ph.D., Novák, P.
Publikace: Biologické systémy a elektromagnetické pole. Praha: ČVUT FEL, Katedra elektromagnetického pole, 1999, pp. 51-53. ISBN 80-01-01997-7.
Rok: 1999

Pracoviště: Katedra elektromagnetického pole

Intracavitary Applicators for BPH Thermotherapy

Autoři: prof. Ing. Jan Vrba, CSc., Lapeš, M., Ing. Ladislav Oppl, Ph.D., Saliba, G., Domeš, J.
Publikace: Biologické systémy a elektromagnetické pole. Praha: ČVUT FEL, Katedra elektromagnetického pole, 1999. pp. 48-50. ISBN 80-01-01997-7.
Rok: 1999

Pracoviště: Katedra elektromagnetického pole

Microwave Applicators for BHP Thermotherapy

Autoři: prof. Ing. Jan Vrba, CSc., Domeš, J., Lapeš, M., Ing. Ladislav Oppl, Ph.D., Saliba, G.
Publikace: The 10th Conference on Microwave Techniques COMITE 1999. Prague: Czechoslovakia Section IEEE, 1999. pp. 229-230. ISBN 80-902417-3-5.
Rok: 1999

Pracoviště: Katedra elektromagnetického pole

Microwave Applicators for BPH Thermotherapy

Autoři: prof. Ing. Jan Vrba, CSc., Lapeš, M., Domeš, J., Ing. Ladislav Oppl, Ph.D., Saliba, G.
Publikace: IPEM Meetings: Microwave and RF Fields - Medical Application and Safety Related Issues Meeting. York: The Institute of Physics and Engineering in Medicine, 1999. pp. 37.
Rok: 1999

Pracoviště: Katedra elektromagnetického pole

Microwave Applicators for Deep Thermotherapy

Autoři: prof. Ing. Jan Vrba, CSc., Lapeš, M., Zuna, I., Peschke, P., Poušek, L.
Publikace: The 10th Conference on Microwave Techniques COMITE 1999. Prague: Czechoslovakia Section IEEE, 1999. pp. 193-195. ISBN 80-902417-3-5.
Rok: 1999

Pracoviště: Katedra elektromagnetického pole

Microwave Hyperthermia Applicator for Animal Experiments

Autoři: prof. Ing. Jan Vrba, CSc., Zuna, I., Poušek, L.
Publikace: Proceedings of Workshop 99. Praha: České vysoké učení technické v Praze, 1999. pp. 340.
Rok: 1999

Pracoviště: Katedra elektromagnetického pole

Microwave Hyperthermia Applicator for Animal Experiments

Autoři: prof. Ing. Jan Vrba, CSc., Zuna, I., Peschke, P., Poušek, L., Lapeš, M., Ing. Ladislav Oppl, Ph.D., Novák, P.
Publikace: The 10th Conference on Microwave Techniques COMITE 1999. Prague: Czechoslovakia Section IEEE, 1999. pp. 197-199. ISBN 80-902417-3-5.
Rok: 1999

Pracoviště: Katedra elektromagnetického pole

Nichtinvasive Bestimmung der Temperaturverteilung im Zielbereich der Hyperthermie durch diagnostischen Ultraschal

Autoři: Novák, P., Poušek, L., Zuna, I., Peschke, P., Lorenz, A., prof. Ing. Jan Vrba, CSc., Schreib, P.
Publikace: 23. Dreilaendertreffen Ultraschall 99. Stuttgart: Georg Thieme Verlag, 1999. pp. 132. ISSN 0172-4614.
Rok: 1999

Pracoviště: Katedra elektromagnetického pole

NMR Compatibility of Microwave Hyperthermia Applicators

Autoři: prof. Ing. Jan Vrba, CSc., Zuna, I., Peschke, P., Schad, L., Poušek, L., Lapeš, M., Ing. Ladislav Oppl, Ph.D., Novák, P.
Publikace: IPEM Meetings: Microwave and RF Fields - Medical Application and Safety Related Issues Meeting. York: The Institute of Physics and Engineering in Medicine, 1999. pp. 47-48.
Rok: 1999

Pracoviště: Katedra elektromagnetického pole

Noninvasive Temperature Monitoring in the Microwave Heated Rad Pedicle Tumors Ultrasound Tissule Characterisation Method

Autoři: Novák, P., Zuna, I., Poušek, L., Peschke, P., prof. Ing. Jan Vrba, CSc., Schreib, P.
Publikace: Proceedings of the European Medical & Biological Engineering Conference. Vienna: International Federation for Medical & Biological Engineering, 1999. pp. 1032. ISSN 0140-0118.
Rok: 1999

Pracoviště: Katedra elektromagnetického pole

Technical Aspects of Microwave Thermotherapy

Autoři: prof. Ing. Jan Vrba, CSc., Lapeš, M., Ing. Ladislav Oppl, Ph.D.,
Publikace: Bioelectrochemistry and Bioenergetics. 1999, 48(10), 305-309.
Rok: 1999

Pracoviště: Katedra elektromagnetického pole

Treatment Planning for Microwave Thermotherapy

Autoři: prof. Ing. Jan Vrba, CSc., Rovenský, P., Lapeš, M.
Publikace: The 10th Conference on Microwave Techniques COMITE 1999. Prague: Czechoslovakia Section IEEE, 1999. pp. 225-227. ISBN 80-902417-3-5.
Rok: 1999

Pracoviště: Katedra elektromagnetického pole

Technical Aspects of Microwave Hyperthermia

Autoři: prof. Ing. Jan Vrba, CSc., Hlaváč, R., Lapeš, M., Ing. Ladislav Oppl, Ph.D., Saliba, G., Smítka, J.
Publikace: Workshop 98. Praha: Czech Technical University in Prague, 1998. p. 881-882.
Rok: 1998

Pracoviště: Katedra elektromagnetického pole

Technical Aspects of Microwave Thermotherapy

Autoři: prof. Ing. Jan Vrba, CSc., Lapeš, M., Kouba, O., Ing. Ladislav Oppl, Ph.D., Hlaváč, R., Saliba, G., Smítka, J.
Publikace: Biological Systems and Electromagnetic Field. Praha: ČVUT FEL, Katedra elektromagnetického pole, 1998, pp. 51. ISBN 80-01-01821-0.
Rok: 1998

Pracoviště: Katedra elektromagnetického pole

Audit CRE zaměřený na institucionální kvalitu evropských univerzit

Autoři: prof. Ing. Jan Vrba, CSc.,
Publikace: Aula. 1997, 5(1), 7-14. ISSN 1210-6658.
Rok: 1997

Pracoviště: Katedra elektromagnetického pole

Behaviour of Hyperthermia Waveguide Applicators Near to the CUT-OFF Frequency

Autoři: prof. Ing. Jan Vrba, CSc., Lapeš, M., Franconi, C.
Publikace: COMITE 1997. Pardubice: Univerzita Pardubice, 1997, pp. 149-151. ISBN 80-902417-0-0.
Rok: 1997

Pracoviště: Katedra elektromagnetického pole

Behaviour of Waveguide Applicators Near to the Cut-off Frequency

Autoři: prof. Ing. Jan Vrba, CSc., Lapeš, M., Franconi, C.
Publikace: MIOP 97. Hagenburg: Network, 1997, pp. 528-530. ISBN 3-924651-53-1.
Rok: 1997

Pracoviště: Katedra elektromagnetického pole

Development and Evaluation of New Microwave Hyperthermia Applicators

Autoři: prof. Ing. Jan Vrba, CSc., Franconi, C., Lapeš, M., Voleš, O., Ing. Ladislav Oppl, Ph.D., Bíža, S., Hlaváč, R.
Publikace: Biologické systémy a elektromagnetické pole. Praha: ČVUT FEL, Katedra elektromagnetického pole, 1997. pp. 47-48. ISBN 80-01-01660-9.
Rok: 1997

Pracoviště: Katedra elektromagnetického pole

Development and Evaluation of New Microwave Hyperthermia Applicators

Autoři: prof. Ing. Jan Vrba, CSc., Hlaváč, R., Franconi, C., Lapeš, M., Voleš, O., Ing. Ladislav Oppl, Ph.D., Bíža, S.
Publikace: Biologické systémy a elektromagnetické pole. Praha: ČVUT FEL, Katedra elektromagnetického pole, 1997, pp. 47-49. ISBN 80-01-01660-9.
Rok: 1997

Pracoviště: Katedra elektromagnetického pole

Hyperthermia Waveguide Applicators: Frequency Behaviour of SAR

Autoři: prof. Ing. Jan Vrba, CSc., Franconi, C., Lapeš, M.
Publikace: Biologické systémy a elektromagnetické pole. Praha: ČVUT FEL, Katedra elektromagnetického pole, 1997, pp. 50-52. ISBN 80-01-01660-9.
Rok: 1997

Pracoviště: Katedra elektromagnetického pole

Technical and Clinical Aspects of Microwave Thermotherapy in the Czech Republic

Autoři: prof. Ing. Jan Vrba, CSc., Lapeš, M.
Publikace: Medical Applications of Microwave and RF. Fields. London: Institut of Physics, 1997, pp. 35-37.
Rok: 1997

Pracoviště: Katedra elektromagnetického pole

Applications for Photodynamic Therapy Measurements and Realisation

Autoři: Novotný, K., prof. Ing. Jan Vrba, CSc.,
Publikace: Workshop 96. Praha: České vysoké učení technické v Praze, 1996. pp. 905-906.
Rok: 1996

Pracoviště: Katedra elektromagnetického pole

Development and Evaluation of New Microwave Hyperthermia Applicators

Autoři: prof. Ing. Jan Vrba, CSc., Franconi, C., Lapeš, M., Bíža, S., Voleš, O.
Publikace: 26th European Microwave Conference. London: Nexus Media Limited, 1996.
Rok: 1996

Pracoviště: Katedra elektromagnetického pole

Electromagnetic Exposure of Mobile Telephones Users

Autoři: Vokurka, J., prof. Ing. Jan Vrba, CSc., Dlouhý, R.
Publikace: Workshop 96. Praha: České vysoké učení technické v Praze, 1996. pp. 907-908.
Rok: 1996

Pracoviště: Katedra elektromagnetického pole

Heating Features of The "HEMA" Subcutaneous Hyperthermia Applicators

Autoři: prof. Ing. Jan Vrba, CSc., Franconi, C., Novosad, T., Vannucci, I.
Publikace: Hyperthermic Oncology 96. Roma: University of Roma, 1996. pp. 220.
Rok: 1996

Pracoviště: Katedra elektromagnetického pole

Theoretical Limits for the Penetration Depth of Intracavitary Applicators

Autoři: prof. Ing. Jan Vrba, CSc., Franconi, C., Lapeš, M.
Publikace: International Journal of Hyperthermia. 1996, l2(6), 737-742. ISSN 0265-6736.
Rok: 1996

Pracoviště: Katedra elektromagnetického pole

Waveguide Applicator Properties Near to the Cut-Off Frequency

Autoři: prof. Ing. Jan Vrba, CSc., Voleš, O., Ing. Ladislav Oppl, Ph.D., Franconi, C., Lapeš, M.
Publikace: II International Congress on Hyperthermic Oncology 96. Roma: University of Roma, 1996. pp. 219.
Rok: 1996

Pracoviště: Katedra elektromagnetického pole

Applicators for Photodynamic Therapy

Autoři: Novotný, K., prof. Ing. Jan Vrba, CSc.,
Publikace: Workshop 95. Praha: České vysoké učení technické v Praze, 1995. pp. 703-704.
Rok: 1995

Pracoviště: Katedra elektromagnetického pole

Electromagnetic Exposure of Mobile-Telephone Users

Autoři: Vokurka, J., prof. Ing. Jan Vrba, CSc., prof. Ing. Zbyněk Škvor, CSc., Dlouhý, R.
Publikace: Workshop 95. Praha: České vysoké učení technické v Praze, 1995. pp. 701-702.
Rok: 1995

Pracoviště: Katedra elektromagnetického pole

Electromagnetic Hyperthermia for Cancer Treatment

Autoři: prof. Ing. Jan Vrba, CSc., Lapeš, M.
Publikace: Bioph. Aspects of Coherence. 1995.
Rok: 1995

Pracoviště: Katedra elektromagnetického pole

Evaluation of Intracavitary Microwave Applicators for Hyperthermia Cancer Treatment

Autoři: prof. Ing. Jan Vrba, CSc., Voleš, O., Bíža, S., Ing. Ladislav Oppl, Ph.D., Lapeš, M., Franconi, C.
Publikace: Proceedings of the MIOP 95 Conference. Hagenburg: Network, 1995. pp. 153-156. ISBN 3-924651-45-0.
Rok: 1995

Pracoviště: Katedra elektromagnetického pole

Intracavitary Hypermia Applicators for Cancer Treatment

Autoři: prof. Ing. Jan Vrba, CSc., Lapeš, M., Voleš, O., Ing. Ladislav Oppl, Ph.D.,
Publikace: ESHO 95. 1995. pp. 32.
Rok: 1995

Pracoviště: Katedra elektromagnetického pole

Lékařská přístrojová technika II

Autoři: Kadlec, F., prof. Ing. Jan Vrba, CSc.,
Publikace: Sborník příspěvků na pracovním setkání "Výuka a výzkum v oblasti biomedicínského inženýrství a biotechnologií na FEL ČVUT v Praze". Praha: ČVUT FEL, Katedra řídicí techniky, 1995. pp. 29.
Rok: 1995

Pracoviště: Katedra elektromagnetického pole

Microwave Hyperthermia Cancer Treatment: Apparaturs for 3D Measurement of Applicator SAR Distribution

Autoři: prof. Ing. Jan Vrba, CSc., Bíža, S., Ing. Ladislav Oppl, Ph.D., Voleš, O., Franconi, C.
Publikace: MITEKO 95. Pardubice: HTT Tesla, 1995. pp. 40-45.
Rok: 1995

Pracoviště: Katedra elektromagnetického pole

3D Modelling of Human Exposures to EM Fields

Autoři: prof. Ing. Jan Vrba, CSc., Bíža, S., Lapeš, M., Vokurka, J., Ing. Ladislav Oppl, Ph.D., Voleš, O.
Publikace: International Symposium on Electromagnetic Compatibility. Abstract Book. Roma: University of Rome, Faculty of Engineering, 1994. pp. 23-25.
Rok: 1994

Pracoviště: Katedra elektromagnetického pole

Intracavitary Applicators for Microwave Thermotherapy

Autoři: prof. Ing. Jan Vrba, CSc., Lapeš, M., Bíža, S., Vokurka, J., Novotný, K., Ing. Ladislav Oppl, Ph.D.,
Publikace: CTU Seminar 94. Praha: České vysoké učení technické v Praze, 1994. pp. 25-26.
Rok: 1994

Pracoviště: Katedra elektromagnetického pole

Microwave Applicators for Hyperthermia Cancer Treatment: Apparatus for 3D Measurements of SAR Distribution

Autoři: prof. Ing. Jan Vrba, CSc., Bíža, S., Ing. Ladislav Oppl, Ph.D., Voleš, O.
Publikace: M 94. Conference and Exhibition. London: Wembley Conference and Exhibition Centre, 1994. pp. 94-98. ISBN 0-95180324-7.
Rok: 1994

Pracoviště: Katedra elektromagnetického pole

The Use of Water Phantom for 3D SAR Measurements

Autoři: prof. Ing. Jan Vrba, CSc., Bíža, S., Lapeš, M., Ing. Ladislav Oppl, Ph.D., Voleš, O.
Publikace: Abstract Book of European Societes for Radiation Biology and Hyperthermic Oncology. Amsterdam: Free University, 1994. pp. 35.
Rok: 1994

Pracoviště: Katedra elektromagnetického pole

27 MHz Hybrid Evanescent-Mode Applicators (HEMA) with Flexible Heating Field for Deep and Safe Subcutaneous Hyperthermia

Autoři: Franconi, C., prof. Ing. Jan Vrba, CSc., Montecchia, F.
Publikace: International Journal of Hyperthermia. 1993, 9(5), 655-673. ISSN 0265-6736.
Rok: 1993

DOI: 10.3109/02656739309032054
Odkaz: https://doi.org/10.3109/02656739309032054
Pracoviště: Katedra elektromagnetického pole

Biological Effects of Electromagnetic Field

Autoři: prof. Ing. Jan Vrba, CSc., Vokurka, J., Ing. Ladislav Oppl, Ph.D., Hlaváč, R., Novák, P., Saliba, G., Smítka, J.
Publikace: Workshop 93. Praha: České vysoké učení technické v Praze, 1993. pp. 519.
Rok: 1993

Pracoviště: Katedra elektromagnetického pole

Evanescent-Mode Applicators (EMA) for Superficial and Subcutaneous

Autoři: prof. Ing. Jan Vrba, CSc.,
Publikace: IEEE Transactions on Biomedical Engineering. 1993, 40(5), 397-407. ISSN 0018-9294.
Rok: 1993

DOI: 10.1109/10.243422
Odkaz: https://doi.org/10.1109/10.243422
Pracoviště: Katedra elektromagnetického pole
Anotace:
Paper deals with a study of evanescent mode aplikcator for superficial and subcutaneous hyperthermia for cancer treatment.

Microwave and Optical Applicators for Cancer Treatment

Autoři: prof. Ing. Jan Vrba, CSc., Vokurka, J., Novotný, K., Endal, J., Bíža, S., Sedláček, R.
Publikace: Workshop 93. Praha: České vysoké učení technické v Praze, 1993. pp. 25-26.
Rok: 1993

Pracoviště: Katedra elektromagnetického pole

Treatment Depth Limits of Hyperthermia Intracavitary Applicators

Autoři: prof. Ing. Jan Vrba, CSc.,
Publikace: Micorwaves and Optonics 93. Piscataway: IEEE, 1993. pp. 334-338. ISBN 3-924651-36-1.
Rok: 1993

Pracoviště: Katedra elektromagnetického pole

Planar Circuit Analysis of Microstrip Radial Stub

Autoři: Giannini, F., Sorrentino, R., prof. Ing. Jan Vrba, CSc.,
Publikace: IEEE Transactions on Microwave Theory and Techniques. 1984,(12), 1652-1655. ISSN 0018-9480.
Rok: 1984

Pracoviště: Katedra elektromagnetického pole

Dynamic Permittivity of Microstrip Ring Resonator

Autoři: prof. Ing. Jan Vrba, CSc.,
Publikace: Electronics Letters. 1979, 1979(15), 504-505. ISSN 0013-5194.
Rok: 1979

DOI: 10.1049/el:19790364
Odkaz: https://doi.org/10.1049/el:19790364
Pracoviště: Katedra elektromagnetického pole
Anotace:
Paper deals with a study of dynamic permitivity for various modes configurations, which are excited in annular resonator.

Microwave Planar Networks - Annular Structure

Autoři: Dinzeo, G., prof. Ing. Jan Vrba, CSc.,
Publikace: Electronics Letters. 1978, 16(14), 526-528. ISSN 0013-5194.
Rok: 1978

Pracoviště: Katedra elektromagnetického pole
Anotace:
Paper deals with modes configurations, which are excited in annular resonator.

Microwave thermotherapy: Study of hot-spots induced by electromagnetic surface waves

Autoři: prof. Ing. Jan Vrba, CSc., Vrbová, B., Vrba, D.
Publikace: In:

Pracoviště: Katedra elektromagnetického pole
Anotace:
This paper is a contribution to theory of microwave applicators used e.g. in cancer treatment by electromagnetically induced hyperthermia, but discussed problems can occur in microwave thermotherapy in general. Paper deals with a study of mechanism of excitations of surface waves propagating around the treated area-one kind of parasitic effects, which can significantly complicate real treatment of patients (these superficial waves can create superficial hot spots outside treated area). Appropriate treatment planning by aid of numerical simulations of SAR distribution can prevent such cases. In this paper we will demonstrate a possibility to eliminate excitations of surface waves by optimization of water bolus shape and dimensions

prof. Ing. Jan Vrba, CSc.

Všechny publikace

Applications of Microwaves in Medicine and Biology

Model of a 4-waveguide Regional Applicator for Microwave Hyperthermia

Sensor for Microwave Medical Diagnostics Based on Array of 8 Waveguides

UWB Bowtie Antenna for Medical Microwave Imaging Applications

Waveguide Array Applicator for Microwave Medical Imaging

Computer-aided design methodology for inductive compensated microwave class-E power amplifier

Experimental Study of Optimal Antenna Array Configuration for Non-invasive UWB Microwave Temperature Monitoring during Hyperthermia

Advanced Temperature Dielectric Spectroscopy Of Muscle Phantom At Microwave Frequencies

Electromagnetic communication between cells through tunneling nanotubes

Temperature Dependent Dielectric Properties of Tissue Mimicking Phantom Material in the Microwave Frequency Range

Temperature dependent dielectric spectroscopy of muscle tissue phantom

Applications of Microwaves in Medicine and Biology

Feasibility of Pancreatic Cancer Treatment by Aid of Microwave Interstitial Hyperthermia Applicators

High-water Content Phantom for Microwave Imaging and Microwave Hyperthermia

Lens Applicator for Deep-local Treatment of Cancer by Microwave Hyperthermia

Non-contact Monitoring of Respiration and Heart Activity of Infants Using UWB Signals

Numerical Study of Differential Temperature Measurement in Human Muscle Tissue using UWB Radar

Research of Biological Effects of em Field in Microwave Frequency Band

Temperature dependent dielectric spectroscopy of muscle tissue phantom

Ultra-Wideband Temperature Dependent Dielectric Spectroscopy of Blood in the Microwave Frequency Range

Ultra-wideband temperature dependent dielectric spectroscopy of porcine muscle in the microwave frequency range

Ultra-Wideband Temperature Dependent Dielectric Spectroscopy of Porcine Tissue and Blood in the Microwave Frequency Range

Microwave Interstitial Applicator Array for Treatment of Pancreatic Cancer

Microwave non-invasive temperature monitoring using UWB radar for cancer treatment by hyperthermia

Microwaves in Medical Diagnostics and Treatment

Numerical Study of Hyperthermia Applicator System for Tumor Treatment in Head and Neck Region

Numerical Study of Stroke Detection Using UWB Radar

Perspective applications of microwaves in medicine

Preliminary Investigations for Non-invasive Temperature Change Detection in Thermotherapy by Means of UWB Microwave Radar

Preliminary Investigations for Reliable Temperature Dependent UWB Dielectric Spectroscopy of Tissues and Tissue Mimicking Phantom Materials

Research of Biological Effects of EM Field in Microwave Frequency Band

Comparative Study of Antennas for Microwave Tomography

Měření komplexní permitivity biologických tkání

Microwave based medical imaging

Microwave Hyperthermia System for Head and Neck Area with Noninvasive UWB Temperature Change Detection

Numerical Feasibility Study of New Combined Hyperthermia System for Head and Neck Region

Optimization of Microwave Hyperthermia Applicator System for Deep Placed Tumors Treatment in Head and Neck Area

Comparison of three UWB microwave antennas intended for brain stroke detection system

Energy Parasites Trigger Oncogene Mutation

Feasibility Study of Temperature Change Detection in Phantom Using M-sequence Radar

Waveguide Applicator System for Head and Neck Hyperthermia Treatment

Array of Spiral Applicators for Local Thermotherapy

Design, Evaluation and Validation of Planar Antenna Array for Breast Hyperthermia Treatment

Development of applicator for microwave hyperthermia system for treatment of mice

Diseases caused by defects of energy level and loss of coherence in living cells

E-field distribution measurement system for hyperthermia applicators with LED sensor

EM exposure system with well defined dosimetry

Feasibility study of microwave interstitial applicator array for treatment pancreatic cancer (Conference Paper)

Measurement of electromagnetic activity of living cells

Mitochondrial dysfunction and disturbed coherence: Gate to cancer

Study of Hot Spots by Oncological Patients with Metal Implants in Head and Neck Region

Suitable Use of Nanostructures in the Treatment of Tumors by the Radiofrequency Ablation Method

UWB waveguide breast tumor detection system based on delay and sum reconstruction algorithm

Waveguide hyperthermia applicator with circular polarisation

Applicator for Superficial Microwave Hyperthermia Filled with Anisotropic Dielectric Media: Numerical Investigation of Design Degrees of Freedom

Cancer - Pathological Breakdown of Coherent Energy States

High-frequency electromagnetic radiation and the production of free radicals in four mouse organs

Interstitial Applicators for Breast Cancer Treatment by Microwave Thermoablation

Matrix of Interstitial Applicators for MicrowaveThermoablation

Measurement of Temperature Increase of Metal Hip Replacements During Magnetic Resonance Imaging

Microwave Hyperthermia Treatment of Neck Cancer Using Eight UWB Antennas

Microwave Thermotherapy: Hot-Spots Induced by Surface EM Waves

Microwaves in Medical Diagnostics and Treatment

Oriented Array of Waveguide Applicators for Local Thermotherapy

Space Distribution of SAR and Temperature in Human Body Model with Tumor Using Waveguide Applicator Array

Study of Superposition of SAR Distribution Created by External and Interstitial Applicator

System for Animal EM Exposure with well Defined Dosimetry

Theory and Design of Microwave Applicator Coupled to Biological Tissue Based on Impedance Matching

Thermoablation for Breast Cancer Treatment Using

Two-channel Measurement of the Ultra-weak Photon emission from a yeast culture during its growth

Utilization of Waveguide Applicators Combination for Electromagntic Field Focusing

Zeroth-order Mode Resonator Metamaterial Applicators for Superficial and Deep Local Microwave Hyperthermia

Application of EM Field in Medicine

Biophysical Insights into Cancer Transformation and Treatment

EM Field and Biological Systems Interactions

EM Field based Microwave Technologies in Medicine

Microwave Thermotherapy: Study of Hot-Spots Induced by Electromagnetic Surface Waves

Perspektivní aplikace mikrovlnné techniky v medicíně